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6XSR
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BU of 6xsr by Molmil
Crystal structure of GluA2 AMPA receptor in complex with trans-4-butylcyclohexane carboxylic acid (4-BCCA) inhibitor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2, trans-4-butylcyclohexane-1-carboxylic acid
Authors:Yelshanskaya, M.V, Singh, A.K, Sobolevsky, A.I.
Deposit date:2020-07-16
Release date:2020-12-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.25 Å)
Cite:Structural basis of AMPA receptor inhibition by trans-4-butylcyclohexane carboxylic acid.
Br.J.Pharmacol., 179, 2022
4U4F
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BU of 4u4f by Molmil
Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, ...
Authors:Yelshanskaya, M.V, Li, M, Sobolevsky, A.I.
Deposit date:2014-07-23
Release date:2014-08-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.79 Å)
Cite:Structure of an agonist-bound ionotropic glutamate receptor.
Science, 345, 2014
4U4G
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BU of 4u4g by Molmil
Structure of GluA2* in complex with competitive antagonist ZK 200775
Descriptor: Glutamate receptor 2, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Yelshanskaya, M.V, Li, M, Sobolevsky, A.I.
Deposit date:2014-07-23
Release date:2014-10-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (4.49 Å)
Cite:Structure of an agonist-bound ionotropic glutamate receptor.
Science, 345, 2014
5L1H
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BU of 5l1h by Molmil
AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor GYKI53655
Descriptor: (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2
Authors:Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I.
Deposit date:2016-07-29
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.801 Å)
Cite:Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
5L1B
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BU of 5l1b by Molmil
AMPA subtype ionotropic glutamate receptor GluA2 in Apo state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Glutamate receptor 2
Authors:Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I.
Deposit date:2016-07-28
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
5L1F
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BU of 5l1f by Molmil
AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor Perampanel
Descriptor: 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2
Authors:Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I.
Deposit date:2016-07-29
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
5L1E
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BU of 5l1e by Molmil
AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one, Glutamate receptor 2
Authors:Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I.
Deposit date:2016-07-29
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.37 Å)
Cite:Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
5L1G
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BU of 5l1g by Molmil
AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br
Descriptor: (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2
Authors:Yelshanskaya, M.V, Singh, A.K, Sampson, J.M, Sobolevsky, A.I.
Deposit date:2016-07-29
Release date:2016-10-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (4.507 Å)
Cite:Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs.
Neuron, 91, 2016
7TNO
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BU of 7tno by Molmil
Complex GGGN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNP
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BU of 7tnp by Molmil
Complex GGGG of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNK
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BU of 7tnk by Molmil
Complex GNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNM
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BU of 7tnm by Molmil
Complex GNGN2 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (4.74 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNJ
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BU of 7tnj by Molmil
Complex NNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNL
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BU of 7tnl by Molmil
Complex GNGN1 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
7TNN
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BU of 7tnn by Molmil
Complex GGNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera
Authors:Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2022-01-21
Release date:2022-04-20
Last modified:2022-05-18
Method:ELECTRON MICROSCOPY (3.91 Å)
Cite:Opening of glutamate receptor channel to subconductance levels.
Nature, 605, 2022
6O9G
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BU of 6o9g by Molmil
Open state GluA2 in complex with STZ and blocked by AgTx-636, after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2019-03-13
Release date:2019-03-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DM0
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BU of 6dm0 by Molmil
Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DM1
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BU of 6dm1 by Molmil
Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6DLZ
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BU of 6dlz by Molmil
Open state GluA2 in complex with STZ after micelle signal subtraction
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit
Authors:Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
Deposit date:2018-06-04
Release date:2018-08-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
5IWR
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BU of 5iwr by Molmil
Structure of Transient Receptor Potential (TRP) channel TRPV6 in the presence of barium
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, BARIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Saotome, K, Singh, A.K, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2016-03-22
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.85 Å)
Cite:Crystal structure of the epithelial calcium channel TRPV6.
Nature, 534, 2016
5IWT
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BU of 5iwt by Molmil
Structure of Transient Receptor Potential (TRP) channel TRPV6 in the presence of gadolinium
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, GADOLINIUM ATOM, Transient receptor potential cation channel subfamily V member 6
Authors:Saotome, K, Singh, A.K, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2016-03-22
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Crystal structure of the epithelial calcium channel TRPV6.
Nature, 534, 2016
5IWK
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BU of 5iwk by Molmil
Structure of Transient Receptor Potential (TRP) channel TRPV6
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Saotome, K, Singh, A.K, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2016-03-22
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.247 Å)
Cite:Crystal structure of the epithelial calcium channel TRPV6.
Nature, 534, 2016
5IWP
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BU of 5iwp by Molmil
Structure of Transient Receptor Potential (TRP) channel TRPV6 in the presence of calcium
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6
Authors:Saotome, K, Singh, A.K, Yelshanskaya, M.V, Sobolevsky, A.I.
Deposit date:2016-03-22
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Crystal structure of the epithelial calcium channel TRPV6.
Nature, 534, 2016
5VHX
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BU of 5vhx by Molmil
GluA2-1xGSG1L bound to ZK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Germ cell-specific gene 1-like protein, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I.
Deposit date:2017-04-13
Release date:2017-05-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
Neuron, 94, 2017
5VHW
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BU of 5vhw by Molmil
GluA2-0xGSG1L bound to ZK
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 2,Germ cell-specific gene 1-like protein, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid
Authors:Twomey, E.C, Yelshanskaya, M.V, Grassucci, R.A, Frank, J, Sobolevsky, A.I.
Deposit date:2017-04-13
Release date:2017-05-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
Neuron, 94, 2017

 

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