Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1SKO
DownloadVisualize
BU of 1sko by Molmil
MP1-p14 Complex
Descriptor: Late endosomal/lysosomal Mp1 interacting protein, Mitogen-activated protein kinase kinase 1 interacting protein 1
Authors:Lunin, V.V, Munger, C, Wagner, J, Ye, Z, Cygler, M, Sacher, M.
Deposit date:2004-03-05
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structure of the MAP kinase scaffold MP1 bound to its partner p14: a complex with a critical role in endosomal MAP kinase signaling
J.Biol.Chem., 279, 2004
6O9X
DownloadVisualize
BU of 6o9x by Molmil
Structure of human PARG complexed with JA2-4
Descriptor: 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
6OA1
DownloadVisualize
BU of 6oa1 by Molmil
Structure of human PARG complexed with JA2120
Descriptor: 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase
Authors:Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A.
Deposit date:2019-03-15
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
7KCF
DownloadVisualize
BU of 7kcf by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AGI-24512
Descriptor: 1,2-ETHANEDIOL, 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, GLYCEROL, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KDA
DownloadVisualize
BU of 7kda by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 34
Descriptor: 2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-08
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KDB
DownloadVisualize
BU of 7kdb by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 35
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 6-(4-hydroxyphenyl)-2,3-diphenyl-5-[(1H-pyrazol-3-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-08
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCC
DownloadVisualize
BU of 7kcc by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270
Descriptor: 1,2-ETHANEDIOL, 3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-[(pyridin-2-yl)amino]pyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
7KCE
DownloadVisualize
BU of 7kce by Molmil
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 2
Descriptor: 5-methyl-2,3-diphenylpyrazolo[1,5-a]pyrimidin-7(4H)-one, CHLORIDE ION, S-ADENOSYLMETHIONINE, ...
Authors:Padyana, A, Jin, L.
Deposit date:2020-10-05
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
J.Med.Chem., 64, 2021
5V6G
DownloadVisualize
BU of 5v6g by Molmil
Crystal structure of Influenza A virus Matrix Protein M1(NLS-88R)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-16
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V8A
DownloadVisualize
BU of 5v8a by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88R, pH 7.3)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Zhou, Q, Chiang, M.-J, Kosikova, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7S
DownloadVisualize
BU of 5v7s by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E, pH 6.2)
Descriptor: Matrix protein 1, PHOSPHATE ION
Authors:Musayev, F.N, Safo, M.K, Althufairi, B, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J, Zhou, Q.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7B
DownloadVisualize
BU of 5v7b by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
3LD1
DownloadVisualize
BU of 3ld1 by Molmil
Crystal Structure of IBV Nsp2a
Descriptor: Replicase polyprotein 1a
Authors:Xu, Y, Cong, L, Wei, L, Fu, J, Chen, C, Yang, A, Tang, H, Bartlam, M, Rao, Z.
Deposit date:2010-01-12
Release date:2011-05-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:IBV nsp2 is an endosome-associated protein and viral pathogenicity factor
To be Published
7BPB
DownloadVisualize
BU of 7bpb by Molmil
Human AAA+ ATPase VCP mutant - T76E, AMP-PNP bound form, Conformation I
Descriptor: ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Yang, C, Zhang, H.
Deposit date:2020-03-22
Release date:2021-03-31
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
7BP9
DownloadVisualize
BU of 7bp9 by Molmil
Human AAA+ ATPase VCP mutant - T76E, ADP-bound form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Yang, C, Zhang, H.
Deposit date:2020-03-21
Release date:2021-03-31
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
7BPA
DownloadVisualize
BU of 7bpa by Molmil
Human AAA+ ATPase VCP mutant - T76A, AMP-PNP-bound form, Conformation I
Descriptor: ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase
Authors:Yang, C, Zhang, H.
Deposit date:2020-03-21
Release date:2021-03-31
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
7BP8
DownloadVisualize
BU of 7bp8 by Molmil
Human AAA+ ATPase VCP mutant - T76A, ADP-bound form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase
Authors:Yang, C, Zhang, H.
Deposit date:2020-03-21
Release date:2021-03-31
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle.
Cell Death Differ., 2022
5GRD
DownloadVisualize
BU of 5grd by Molmil
Crystal structure of 10-mer peptide from EBV in complex with HLA-A1101.
Descriptor: Beta-2-microglobulin, Epstein Barr Virus, Latent membrane protein 2 epitope, ...
Authors:Tadwal, V.S, Xiao, Z, Ren, E.C.
Deposit date:2016-08-10
Release date:2017-08-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
5GSD
DownloadVisualize
BU of 5gsd by Molmil
Crystal structure of LMP2 peptide from EBV in complex with HLA-A*11:01
Descriptor: Beta-2-microglobulin, Epstein Barr Virus, Latent membrane protein-2 epitope, ...
Authors:Tadwal, V.S, Xiao, Z, Ren, E.C.
Deposit date:2016-08-15
Release date:2017-08-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
5GRG
DownloadVisualize
BU of 5grg by Molmil
Crystal structure of dual peptide from EBV in complex with HLA-A*11:01
Descriptor: Beta-2-microglobulin, Epstein Barr Virus, Latent Membrane Protein 2 epitope, ...
Authors:Tadwal, V.S, Xiao, Z, Ren, E.C.
Deposit date:2016-08-11
Release date:2017-08-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Dual non-contiguous peptide occupancy of HLA class I evoke antiviral human CD8 T cell response and form neo-epitopes with self-antigens
Sci Rep, 7, 2017
6DDR
DownloadVisualize
BU of 6ddr by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 13A9, Anti-MICA Fab fragment light chain clone 13A9, GLYCEROL, ...
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDM
DownloadVisualize
BU of 6ddm by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 1D5, Anti-MICA Fab fragment light chain clone 1D5, MHC class I polypeptide-related sequence A
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6DDV
DownloadVisualize
BU of 6ddv by Molmil
Crystal Structure Analysis of the Epitope of an Anti-MICA Antibody
Descriptor: Anti-MICA Fab fragment heavy chain clone 6E1, Anti-MICA Fab fragment light chain clone 6E1, MHC class I chain-related protein A
Authors:Matsumoto, M.L.
Deposit date:2018-05-10
Release date:2018-10-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies.
MAbs, 11, 2019
6TGW
DownloadVisualize
BU of 6tgw by Molmil
Crystal structure of human Aldehyde dehydrogenase 1A3 in complex with a selective inhibitor
Descriptor: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, methyl 5-(1,3-benzodioxol-5-yl)-2-phenyl-pyrazolo[1,5-a]pyrimidine-7-carboxylate
Authors:Garavaglia, S, Rizzi, M.
Deposit date:2019-11-18
Release date:2021-06-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.
Commun Biol, 4, 2021
4ZSE
DownloadVisualize
BU of 4zse by Molmil
Crystal structure of EGFR 696-1022 T790M/V948R, crystal form II
Descriptor: 1,2-ETHANEDIOL, Epidermal growth factor receptor, MAGNESIUM ION, ...
Authors:Yan, X.E, Yun, C.H.
Deposit date:2015-05-13
Release date:2016-06-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Ibrutinib Selectively and Irreversibly Targets EGFR-mutant non-Small Cell Lung Cancer Cells
To Be Published

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon