Author results

2Y5B
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STRUCTURE OF USP21 IN COMPLEX WITH LINEAR DIUBIQUITIN-ALDEHYDE
Descriptor:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21, UBIQUITIN, ZINC ION, ...
Authors:Ye, Y., Akutsu, M., Reyes-Turcu, F., Enchev, R.I., Wilkinson, K.D., Komander, D.
Deposit date:2011-01-12
Release date:2012-01-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Polyubiquitin Binding and Cross-Reactivity in the Usp Domain Deubiquitinase Usp21.
Embo Rep., 12, 2011
5AY9
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CRYSTAL STRUCTURE OF RUMINOCOCCUS ALBUS 4-O-BETA-D-MANNOSYL-D-GLUCOSE PHOSPHORYLASE (RAMP1)
Descriptor:4-O-beta-D-mannosyl-D-glucose phosphorylase
Authors:Ye, Y., Saburi, W., Kato, K., Yao, M.
Deposit date:2015-08-11
Release date:2016-03-23
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies
Febs Lett., 590, 2016
5AYC
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CRYSTAL STRUCTURE OF RUMINOCOCCUS ALBUS 4-O-BETA-D-MANNOSYL-D-GLUCOSE PHOSPHORYLASE (RAMP1) IN COMPLEXES WITH SULFATE AND 4-O-BETA-D-MANNOSYL-D-GLUCOSE
Descriptor:4-O-beta-D-mannosyl-D-glucose phosphorylase, SULFATE ION, BETA-D-GLUCOSE, ...
Authors:Ye, Y., Saburi, W., Kato, K., Yao, M.
Deposit date:2015-08-13
Release date:2016-03-23
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies.
Febs Lett., 590, 2016
5AYD
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CRYSTAL STRUCTURE OF RUMINOCOCCUS ALBUS BETA-(1,4)-MANNOOLIGOSACCHARIDE PHOSPHORYLASE (RAMP2) IN COMPLEXES WITH PHOSPHATE
Descriptor:Beta-1,4-mannooligosaccharide phosphorylase, PHOSPHATE ION
Authors:Ye, Y., Saburi, W., Kato, K., Yao, M.
Deposit date:2015-08-13
Release date:2016-03-23
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies.
Febs Lett., 590, 2016
5AYE
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CRYSTAL STRUCTURE OF RUMINOCOCCUS ALBUS BETA-(1,4)-MANNOOLIGOSACCHARIDE PHOSPHORYLASE (RAMP2) IN COMPLEXES WITH PHOSPHATE AND BETA-(1,4)-MANNOBIOSE
Descriptor:Beta-1,4-mannooligosaccharide phosphorylase, PHOSPHATE ION, BETA-D-MANNOSE
Authors:Ye, Y., Saburi, W., Kato, K., Yao, M.
Deposit date:2015-08-13
Release date:2016-03-23
Last modified:2016-04-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into the difference in substrate recognition of two mannoside phosphorylases from two GH130 subfamilies.
Febs Lett., 590, 2016
1T6W
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RATIONAL DESIGN OF A CALCIUM-BINDING ADHESION PROTEIN NMR, 20 STRUCTURES
Descriptor:hypothetical protein XP_346638, CALCIUM ION
Authors:Yang, W., Wilkins, A.L., Ye, Y., Liu, Z.-R., Urbauer, J.L., Kearney, A., van der Merwe, P.A., Yang, J.J.
Deposit date:2004-05-07
Release date:2005-02-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design of a calcium-binding protein with desired structure in a cell adhesion molecule.
J.Am.Chem.Soc., 127, 2005
3L8B
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CRYSTAL STRUCTURE OF A REPLICATIVE DNA POLYMERASE BOUND TO THE OXIDIZED GUANINE LESION GUANIDINOHYDANTOIN
Descriptor:DNA polymerase, DNA (5'-D(*AP*C*TP*(G35)P*TP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*A)-3'), ...
Authors:Aller, P., Ye, Y., Wallace, S.S., Burrows, C.J., Doublie, S.
Deposit date:2009-12-30
Release date:2010-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of a replicative DNA polymerase bound to the oxidized guanine lesion guanidinohydantoin.
Biochemistry, 49, 2010
3PHU
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS
Descriptor:RNA-directed RNA polymerase L, GLYCEROL
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHW
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN COMPLEX WITH UBIQUITIN
Descriptor:RNA-directed RNA polymerase L, Ubiquitin-40S ribosomal protein S27a, ETHANAMINE
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PHX
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OTU DOMAIN OF CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS IN COMPLEX WITH ISG15
Descriptor:RNA-directed RNA polymerase L, Ubiquitin-like protein ISG15, ZINC ION, ...
Authors:Akutsu, M., Ye, Y., Virdee, S., Komander, D.
Deposit date:2010-11-04
Release date:2011-02-02
Last modified:2014-08-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains.
Proc.Natl.Acad.Sci.USA, 108, 2011
4AE4
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THE UBAP1 SUBUNIT OF ESCRT-I INTERACTS WITH UBIQUITIN VIA A NOVEL SOUBA DOMAIN
Descriptor:UBIQUITIN-ASSOCIATED PROTEIN 1, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, POTASSIUM ION, ...
Authors:Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S.M., Allen, M.D., Bycroft, M., Perisic, O., Ye, Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S.J.D., Martin-Serrano, J., Williams, R.L.
Deposit date:2012-01-06
Release date:2012-03-21
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Structure, 20, 2012
4GGG
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CRYSTAL STRUCTURE OF V66A/L68V CZRA IN THE ZN(II)BOUND STATE.
Descriptor:Repressor protein, ZINC ION, CHLORIDE ION
Authors:Campanello, G.C., Ma, Z., Grossoehme, N.E., Chakrovorty, D.K., Guerra, A.J., Ye, Y., Dann III, C.E., Merz Jr., K.M., Giedroc, D.P.
Deposit date:2012-08-06
Release date:2013-02-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.
J.Mol.Biol., 425, 2013
6GQJ
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CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
Descriptor:Mast/stem cell growth factor receptor Kit, 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQK
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CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 23)
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQL
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CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 35)
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQM
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CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR, AZD3229
Descriptor:Mast/stem cell growth factor receptor Kit, ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide, CHLORIDE ION
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQO
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CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
Descriptor:Vascular endothelial growth factor receptor 2, 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide
Authors:Ogg, D.J., Schimpl, M., Hardy, C.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQP
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CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 23)
Descriptor:Vascular endothelial growth factor receptor 2, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
Authors:Hardy, C.J., Schimpl, M., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQQ
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CRYSTAL STRUCTURE OF HUMAN KDR (VEGFR2) KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 35)
Descriptor:Vascular endothelial growth factor receptor 2, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
Authors:Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
Deposit date:2018-06-07
Release date:2018-09-19
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6K15
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RSC SUBSTRATE-RECRUITMENT MODULE
Descriptor:Chromatin structure-remodeling complex subunit RSC7, Chromatin structure-remodeling complex protein RSC8, Chromatin structure-remodeling complex subunit RSC9, ...
Authors:Ye, Y.P., Wu, H., Chen, K.J., Verma, N., Cairns, B., Gao, N., Chen, Z.C.
Deposit date:2019-05-09
Release date:2019-11-13
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
6KW3
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THE CLASSA RSC-NUCLEOSOME COMPLEX
Descriptor:Histone H4, Histone H3.2, Histone H2A, ...
Authors:Ye, Y.P., Wu, H., Chen, K.J., Verma, N., Cairns, B., Gao, N., Chen, Z.C.
Deposit date:2019-09-05
Release date:2019-11-13
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (7.13 Å)
Cite:Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
6KW4
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THE CLASSB RSC-NUCLEOSOME COMPLEX
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Ye, Y.P., Wu, H., Chen, K.J., Verma, N., Cairns, B., Gao, N., Chen, Z.C.
Deposit date:2019-09-06
Release date:2019-11-13
Last modified:2019-11-27
Method:ELECTRON MICROSCOPY (7.55 Å)
Cite:Structure of the RSC complex bound to the nucleosome.
Science, 366, 2019
6IV8
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THE SELENOMETHIONINE(SEMET)-DERIVED CAS13D BINARY COMPLEX
Descriptor:The selenomethionine (SeMet)-labeled Cas13d, RNA (51-MER), RNA (53-MER), ...
Authors:Zhang, B., Ye, Y.M., Ye, W.W., OuYang, S.Y.
Deposit date:2018-12-02
Release date:2019-06-19
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.
Nat Commun, 10, 2019
6IV9
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THE CAS13D BINARY COMPLEX
Descriptor:Cas13d, crRNA (50-MER), MAGNESIUM ION
Authors:Zhang, B., Ye, Y.M., Ye, W.W., OuYang, S.Y.
Deposit date:2018-12-02
Release date:2019-06-19
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.
Nat Commun, 10, 2019
4WWR
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CRYSTAL STRUCTURE OF BAG6-UBL4A DIMERIZATION DOMAIN
Descriptor:Ubiquitin-like protein 4A, Large proline-rich protein BAG6
Authors:Mock, J.Y., Chartron, J.W., Clemons Jr., W.M.
Deposit date:2014-11-12
Release date:2014-12-24
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
Proc.Natl.Acad.Sci.USA, 112, 2015
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