Author results

2MPK
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CHARACTERIZATION AND STRUCTURE OF THE MIT1 DOMAIN OF A CHITIN SYNTHASE FROM THE OOMYCETE SAPROLEGNIA MONOICA
Descriptor:Chitin synthase 1
Authors:Bulone, V., Szpryngiel, S., Brown, C., Ye, W.
Deposit date:2014-05-27
Release date:2015-05-27
Last modified:2016-09-07
Method:SOLUTION NMR
Cite:Structural and functional characterization of the microtubule interacting and trafficking domains of two oomycete chitin synthases.
Febs J., 283, 2016
4G1T
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CRYSTAL STRUCTURE OF INTERFERON-STIMULATED GENE 54
Descriptor:Interferon-induced protein with tetratricopeptide repeats 2
Authors:Yang, Z., Liang, H., Zhou, Q., Li, Y., Chen, H., Ye, W., Chen, D., Fleming, J., Shu, H., Liu, Y.
Deposit date:2012-07-11
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.
Cell Res., 2012
6BGI
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN NANODISC
Descriptor:Anoctamin-1, CALCIUM ION
Authors:Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, J., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2018-01-17
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6BGJ
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CRYO-EM STRUCTURE OF THE TMEM16A CALCIUM-ACTIVATED CHLORIDE CHANNEL IN LMNG
Descriptor:Anoctamin-1, CALCIUM ION
Authors:Dang, S., Feng, S., Tien, J., Peters, C.J., Bulkley, D., Lolicato, M., Zhao, J., Zuberbuhler, K., Ye, W., Qi, L., Chen, T., Craik, C.S., Jan, Y.N., Minor Jr., D.L., Cheng, Y., Jan, L.Y.
Deposit date:2017-10-28
Release date:2017-12-27
Last modified:2018-04-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
Nature, 552, 2017
6P46
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CRYO-EM STRUCTURE OF TMEM16F IN DIGITONIN WITH CALCIUM BOUND
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P47
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CRYO-EM STRUCTURE OF TMEM16F IN DIGITONIN WITHOUT CALCIUM
Descriptor:Anoctamin-6
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P48
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CRYO-EM STRUCTURE OF CALCIUM-BOUND TMEM16F IN NANODISC WITH SUPPLEMENT OF PIP2 IN CL1
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
6P49
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CRYO-EM STRUCTURE OF CALCIUM-BOUND TMEM16F IN NANODISC WITH SUPPLEMENT OF PIP2 IN CL2
Descriptor:Anoctamin-6, CALCIUM ION
Authors:Feng, S., Dang, S., Han, T.W., Ye, W., Jin, P., Cheng, T., Li, J., Jan, Y.N., Jan, L.Y., Cheng, Y.
Deposit date:2019-05-26
Release date:2019-07-24
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling.
Cell Rep, 28, 2019
4MEJ
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CRYSTAL STRUCTURE OF LACTOBACILLUS HELVETICUS PURINE DEOXYRIBOSYL TRANSFERASE (PDT) WITH THE TRICYCLIC PURINE 8,9-DIHYDRO-9-OXOIMIDAZO[2,1-B]PURINE (N2,3-ETHENOGUANINE)
Descriptor:Nucleoside deoxyribosyltransferase, SULFATE ION, 3H-imidazo[2,1-b]purin-4(5H)-one
Authors:Paul, D., Seckute, J., Ealick, S.E.
Deposit date:2013-08-26
Release date:2014-10-15
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Glycosylation of a tricyclic purine analog at alternative sites by nucleoside 2 -deoxyribosyltransferases
Plos One, 2014
6IV8
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THE SELENOMETHIONINE(SEMET)-DERIVED CAS13D BINARY COMPLEX
Descriptor:The selenomethionine (SeMet)-labeled Cas13d, RNA (51-MER), RNA (53-MER), ...
Authors:Zhang, B., Ye, Y.M., Ye, W.W., OuYang, S.Y.
Deposit date:2018-12-02
Release date:2019-06-19
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.
Nat Commun, 10, 2019
6IV9
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THE CAS13D BINARY COMPLEX
Descriptor:Cas13d, crRNA (50-MER), MAGNESIUM ION
Authors:Zhang, B., Ye, Y.M., Ye, W.W., OuYang, S.Y.
Deposit date:2018-12-02
Release date:2019-06-19
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Two HEPN domains dictate CRISPR RNA maturation and target cleavage in Cas13d.
Nat Commun, 10, 2019
6J8L
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PHYTOPHTHORA SOJAE EFFECTOR PSAVH240 INHIBITS A HOST ASPARTIC PROTEASE SECRETION TO PROMOTE INFECTION
Descriptor:Avh240, SULFATE ION
Authors:Guo, B.
Deposit date:2019-01-19
Release date:2019-02-06
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phytophthora sojae Effector PsAvh240 Inhibits Host Aspartic Protease Secretion to Promote Infection.
Mol Plant, 12, 2019
3PNW
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CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN TDRD3 IN COMPLEX WITH AN ANTI-TDRD3 FAB
Descriptor:FAB light chain, FAB heavy chain, Tudor domain-containing protein 3, ...
Authors:Loppnau, P., Tempel, W., Wernimont, A.K., Lam, R., Ravichandran, M., Adams-Cioaba, M.A., Persson, H., Sidhu, S.S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Cossar, D., Structural Genomics Consortium (SGC)
Deposit date:2010-11-19
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:CDR-H3 Diversity Is Not Required for Antigen Recognition by Synthetic Antibodies.
J.Mol.Biol., 425, 2013
4OBO
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 22), 6-(3-CHLOROPHENYL)QUINAZOLIN-4-AMINE
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-01-07
Release date:2014-04-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.
J.Med.Chem., 57, 2014
4OBP
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 29), 6-(2-FLUOROPYRIDIN-4-YL)PYRIDO[3,2-D]PYRIMIDIN-4-AMINE
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Harris, S.F., Wu, P.
Deposit date:2014-01-07
Release date:2014-04-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.
J.Med.Chem., 57, 2014
4OBQ
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 31), N-[3-(4-AMINOQUINAZOLIN-6-YL)-5-FLUOROPHENYL]-2-(PYRROLIDIN-1-YL)ACETAMIDE
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-01-07
Release date:2014-04-23
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Discovery of Selective 4-Amino-pyridopyrimidine Inhibitors of MAP4K4 Using Fragment-Based Lead Identification and Optimization.
J.Med.Chem., 57, 2014
4U3Y
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APO MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (MAP4K4)
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, DIMETHYL SULFOXIDE
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2016-01-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
to be published
4U3Z
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APO MAP4K4 T181E PHOSPHOMIMETIC MUTANT
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2016-01-06
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
to be published
4U40
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MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 4 (MAP4K4) BOUND TO AMPPNP
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2016-01-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
to be published
4U41
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MAP4K4 BOUND TO INHIBITOR COMPOUND 1
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine, MAGNESIUM ION, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2016-01-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
to be published
4U42
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MAP4K4 T181E MUTANT BOUND TO INHIBITOR COMPOUND 1
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[(3S)-3-(4-methyl-1H-pyrazol-3-yl)piperidin-1-yl]pyrido[3,2-d]pyrimidin-4-amine, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2016-01-06
Method:X-RAY DIFFRACTION (2.504 Å)
Cite:Structural Plasticity and Kinase Activation in a Cohort of MAP4K4 Structures
to be published
4U43
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 6)
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, N-(pyridin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2014-09-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4U44
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 16)
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SODIUM ION, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2014-09-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4U45
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MAP4K4 IN COMPLEX WITH INHIBITOR (COMPOUND 25)
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 6-(1H-pyrazol-4-yl)-N-(pyridin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2014-07-23
Release date:2014-09-03
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.
Bioorg.Med.Chem.Lett., 24, 2014
4ZK5
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MAP4K4 IN COMPLEX WITH INHIBITOR GNE-495
Descriptor:Mitogen-activated protein kinase kinase kinase kinase 4, MAGNESIUM ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Harris, S.F., Wu, P., Coons, M.
Deposit date:2015-04-29
Release date:2015-09-02
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.
Acs Med.Chem.Lett., 6, 2015
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