Author results

1A6X
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STRUCTURE OF THE APO-BIOTIN CARBOXYL CARRIER PROTEIN (APO-BCCP87) OF ESCHERICHIA COLI ACETYL-COA CARBOXYLASE, NMR, 49 STRUCTURES
Descriptor:APO-BIOTIN CARBOXYL CARRIER PROTEIN OF ACETYL-COA CARBOXYLASE
Authors:Yao, X., Wei, D., Soden Junior, C., Summers, M.F., Beckett, D.
Deposit date:1998-03-04
Release date:1998-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the carboxy-terminal fragment of the apo-biotin carboxyl carrier subunit of Escherichia coli acetyl-CoA carboxylase.
Biochemistry, 36, 1997
1B8T
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SOLUTION STRUCTURE OF THE CHICKEN CRP1
Descriptor:PROTEIN (CRP1), ZINC ION
Authors:Yao, X., Perez-Alvarado, G.C., Louis, H.A., Pomies, P., Hatt, C., Summers, M.F., Beckerle, M.C.
Deposit date:1999-02-02
Release date:1999-05-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.
Biochemistry, 38, 1999
3VGY
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STRUCTURE OF HIV-1 GP41 NHR/FUSION INHIBITOR COMPLEX P321
Descriptor:Envelope glycoprotein gp160, CP32M, SULFATE ION
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-08-22
Release date:2012-06-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.034 Å)
Cite:Structural basis of potent and broad HIV-1 fusion inhibitor CP32M
J.Biol.Chem., 287, 2012
3VH7
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STRUCTURE OF HIV-1 GP41 NHR/FUSION INHIBITOR COMPLEX P21
Descriptor:Envelope glycoprotein gp160, CP32M, MAGNESIUM ION
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-08-23
Release date:2012-06-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.019 Å)
Cite:Structural basis of potent and broad HIV-1 fusion inhibitor CP32M
J.Biol.Chem., 287, 2012
3VIE
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HIV-GP41 FUSION INHIBITOR SIFUVIRTIDE
Descriptor:Envelope glycoprotein gp160, Sifuvirtide
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-09-29
Release date:2012-01-18
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide
J.Biol.Chem., 287, 2012
3VTQ
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NOVEL HIV FUSION INHIBITOR
Descriptor:Envelope glycoprotein gp160, fusion inhibitor MT-Sifuvirtide
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2012-06-02
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal structure of a novel HIV fusion inhibitor
To be Published
3W19
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POTENT HIV FUSION INHIBITOR CP32M-2
Descriptor:Transmembrane protein gp41, fusion inhibitor CP32M-2
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2012-11-13
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.278 Å)
Cite:Optimization of novel anti-HIV fusion inhibitor
To be Published
4I2L
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NEW HIV ENTRY INHIBITOR MTSFT/T23 COMPLEX
Descriptor:GP41, inhibitor MTSFT
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-11-22
Release date:2014-01-22
Method:X-RAY DIFFRACTION (1.426 Å)
Cite:Potent antiviral activity of the novel HIV entry inhibitor MTSFT
To be Published
6J2Y
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SOLUTION STRUCTURE OF TRANSLATIONALLY CONTROLLED TUMOR PROTEIN FROM PHOTOSYNTHETIC MICROALGA NANNOCHLOROPSIS OCEANICA
Descriptor:NoTCTP
Authors:Yao, X., Feng, Y.
Deposit date:2019-01-03
Release date:2019-03-13
Method:SOLUTION NMR
Cite:Solution structure of a unicellular microalgae-derived translationally controlled tumor protein revealed both conserved features and structural diversity.
Arch. Biochem. Biophys., 665, 2019
3VGX
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STRUCTURE OF GP41 T21/CP621-652
Descriptor:Envelope glycoprotein gp160, ACETIC ACID, GLYCEROL
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2011-08-22
Release date:2012-04-25
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652.
J.Biol.Chem., 287, 2012
3VTP
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HIV FUSION INHIBITOR MT-C34
Descriptor:Transmembrane protein gp41
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2012-06-02
Release date:2012-08-22
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The M-T hook structure is critical for design of HIV-1 fusion inhibitors.
J.Biol.Chem., 287, 2012
3VU5
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SHORT PEPTIDE HIV ENTRY INHIBITOR SC22EK
Descriptor:Transmembrane protein gp41, SC22, SULFATE ION, ...
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-06-19
Release date:2012-12-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.087 Å)
Cite:Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1
Faseb J., 27, 2013
3VU6
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SHORT PEPTIDE HIV ENTRY INHIBITOR MT-SC22EK WITH A M-T HOOK
Descriptor:Transmembrane protein gp41, MTSC22, SULFATE ION
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-06-19
Release date:2012-12-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.324 Å)
Cite:Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1
Faseb J., 27, 2013
3AQQ
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CRYSTAL STRUCTURE OF HUMAN CRHSP-24
Descriptor:Calcium-regulated heat stable protein 1
Authors:Hou, H., Wang, F., Zhang, W., Wang, D., Li, X., Bartlam, M., Yao, X., Rao, Z.
Deposit date:2010-11-17
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:CRHSP-24 is a novel cargo adaptor trafficking between stress granules and processing bodies
To be Published
3QZQ
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71D IN COMPLEX WITH RUPINTRIVIR
Descriptor:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
Authors:Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
Deposit date:2011-03-07
Release date:2011-08-10
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.7001 Å)
Cite:Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
3QZR
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71A IN COMPLEX WITH RUPINTRIVIR
Descriptor:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, 1,2-ETHANEDIOL
Authors:Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
Deposit date:2011-03-07
Release date:2011-08-10
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.039 Å)
Cite:Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
3R0F
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HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT H133G IN COMPLEX WITH RUPINTRIVIR
Descriptor:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, 1,2-ETHANEDIOL
Authors:Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
Deposit date:2011-03-08
Release date:2011-08-10
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.3083 Å)
Cite:Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
6DCG
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DISCOVERY OF MK-8353: AN ORALLY BIOAVAILABLE DUAL MECHANISM ERK INHIBITOR FOR ONCOLOGY
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Authors:Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A., Shipps Jr., G.W., Doll, R., Shih, N., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
Deposit date:2018-05-06
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
1G03
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NMR STRUCTURE OF N-TERMINAL DOMAIN OF HTLV-I CA1-134
Descriptor:HTLV-I CAPSID PROTEIN
Authors:Cornilescu, C.C., Bouamr, F., Yao, X., Carter, C., Tjandra, N.
Deposit date:2000-10-05
Release date:2001-03-21
Last modified:2016-04-06
Method:SOLUTION NMR
Cite:Structural analysis of the N-terminal domain of the human T-cell leukemia virus capsid protein.
J.Mol.Biol., 306, 2001
1SI5
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PROTEASE-LIKE DOMAIN FROM 2-CHAIN HEPATOCYTE GROWTH FACTOR
Descriptor:hepatocyte growth factor
Authors:Kirchhofer, D., Yao, X., Peek, M., Eigenbrot, C., Lipari, M.T., Billeci, K.L., Maun, H.R., Moran, P., Santell, L., Lazarus, R.A.
Deposit date:2004-02-27
Release date:2004-12-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling
J.Biol.Chem., 279, 2004
3R45
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STRUCTURE OF A CENP-A-HISTONE H4 HETERODIMER IN COMPLEX WITH CHAPERONE HJURP
Descriptor:Histone H3-like centromeric protein A, Histone H4, Holliday junction recognition protein, ...
Authors:Hu, H., Liu, Y., Wang, M., Fang, J., Huang, H., Yang, N., Li, Y., Wang, J., Yao, X., Shi, Y., Li, G., Xu, R.M.
Deposit date:2011-03-17
Release date:2011-04-06
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP
Genes Dev., 25, 2011
4HHV
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CRYSTAL STRUCTURE OF CERAMIDE TRANSFER PROTEIN PLECKSTRIN HOMOLOGY DOMAIN
Descriptor:Collagen type IV alpha-3-binding protein, SULFATE ION, GLYCEROL, ...
Authors:Prashek, J., Truong, T., Yao, X.
Deposit date:2012-10-10
Release date:2013-11-27
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Pleckstrin Homology Domain from the Ceramide Transfer Protein: Implications for Conformational Change upon Ligand Binding.
Plos One, 8, 2013
5HIN
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE (DHODH) WITH 18L COMPOUND
Descriptor:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Huang, J., Wu, D., Lu, Q., Yao, X.
Deposit date:2016-01-12
Release date:2016-07-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of human dihydroorotate dehydrogenase (DHODH) with 18L at 1.60 A resolution
To Be Published
5JJD
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CRYSTAL STRUCTURE OF THE CERAMIDE TRANSFER PROTEIN PH AND START DOMAIN COMPLEX
Descriptor:Collagen type IV alpha-3-binding protein, DI(HYDROXYETHYL)ETHER, TRIETHYLENE GLYCOL
Authors:Prashek, J., Bouyain, S., Yao, X.
Deposit date:2016-04-23
Release date:2017-07-05
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain.
J. Biol. Chem., 292, 2017
3KKR
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CRYSTAL STRUCTURE OF CATALYTIC CORE DOMAIN OF BIV INTEGRASE IN CRYSTAL FORM I
Descriptor:Integrase, NITRATE ION
Authors:Shen, Y.
Deposit date:2009-11-06
Release date:2010-09-22
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.453 Å)
Cite:Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNA
Protein Cell, 1, 2010
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