Author results

2AZX
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CHARGED AND UNCHARGED TRNAS ADOPT DISTINCT CONFORMATIONS WHEN COMPLEXED WITH HUMAN TRYPTOPHANYL-TRNA SYNTHETASE
分子名称:72-MER, Tryptophanyl-tRNA synthetase, SULFATE ION, ...
著者Yang, X.L., Otero, F.J., Ewalt, K.L., Liu, J., Swairjo, M.A., Kohrer, C., RajBhandary, U.L., Skene, R.J., McRee, D.E., Schimmel, P.
登録日2005-09-12
公開日2006-08-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
4XEO
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CRYSTAL STRUCTURE OF HUMAN ALARS CATALYTIC DOMAIN WITH R329H MUTATION
分子名称:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
著者Zhou, H., He, W., Yang, X.L.
登録日2014-12-24
公開日2015-12-30
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Crystal structure of human AlaRS catalytic domain with R329H mutation
To Be Published
2ZT5
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH ATP)
分子名称:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
著者Guo, R.T., Yang, X.L., Schimmel, P.
登録日2008-09-19
公開日2009-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AMPCPP
分子名称:Glycyl-tRNA synthetase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
著者Guo, R.T., Yang, X.L., Schimmel, P.
登録日2008-09-19
公開日2009-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLYCINE AND ATP
分子名称:Glycyl-tRNA synthetase, GLYCINE, ADENOSINE-5'-TRIPHOSPHATE
著者Guo, R.T., Yang, X.L., Schimmel, P.
登録日2008-09-19
公開日2009-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT8
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH GLY-AMP ANALOG
分子名称:Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
著者Guo, R.T., Yang, X.L., Schimmel, P.
登録日2008-09-19
公開日2009-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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CRYSTAL STRUCTURE OF HUMAN GLYCYL-TRNA SYNTHETASE (GLYRS) IN COMPLEX WITH AP4A (COCRYSTALLIZED WITH AP4A)
分子名称:Glycyl-tRNA synthetase, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
著者Guo, R.T., Yang, X.L., Schimmel, P.
登録日2008-12-23
公開日2009-08-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
3BJU
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CRYSTAL STRUCTURE OF TETRAMERIC FORM OF HUMAN LYSYL-TRNA SYNTHETASE
分子名称:Lysyl-tRNA synthetase, CALCIUM ION, LYSINE, ...
著者Guo, M., Yang, X.L., Schimmel, P.
登録日2007-12-04
公開日2008-02-05
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation
Proc.Natl.Acad.Sci.Usa, 105, 2008
3G98
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CRYSTAL STRUCTURE OF THE C-ALA DOMAIN FROM AQUIFEX AEOLICUS ALANYL-TRNA SYNTHETASE
分子名称:Alanyl-tRNA synthetase
著者Guo, M., Yang, X.L., Schimmel, P.
登録日2009-02-13
公開日2009-10-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献The C-Ala domain brings together editing and aminoacylation functions on one tRNA.
Science, 325, 2009
4HVC
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CRYSTAL STRUCTURE OF HUMAN PROLYL-TRNA SYNTHETASE IN COMPLEX WITH HALOFUGINONE AND ATP ANALOGUE
分子名称:Bifunctional glutamate/proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
著者Zhou, H., Sun, L., Yang, X.L., Schimmel, P.
登録日2012-11-06
公開日2013-01-02
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.
Nature, 494, 2012
4XEM
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CRYSTAL STRUCTURE OF WILD TYPE HUMAN ALARS CATALYTIC DOMAIN
分子名称:Alanine--tRNA ligase, cytoplasmic, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, ...
著者Zhou, H., He, W., Yang, X.L.
登録日2014-12-24
公開日2016-02-17
実験手法X-RAY DIFFRACTION (1.278 Å)
主引用文献Crystal structure of wild type human AlaRS catalytic domain
To Be Published
5HWL
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HUMAN GLUTATHIONE S-TRANSFERASE MU2 COMPLEXED WITH BDEA, MONOCLINIC CRYSTAL FORM
分子名称:Glutathione S-transferase Mu 2, GLUTATHIONE, N,N'-(butane-1,4-diyl)bis{2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetamide}
著者Zhang, X., Wei, J., Wu, S., Zhang, H.P., Luo, M., Yang, X.L., Liao, F., Wang, D.Q.
登録日2016-01-29
公開日2017-11-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Human glutathione s-transferase Mu2 complexed with BDEA, monoclinic crystal form
To Be Published
5THH
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CRYSTAL STRUCTURE OF A HUMAN TYROSYL-TRNA SYNTHETASE MUTANT
分子名称:Tyrosine--tRNA ligase, cytoplasmic, TYROSINE
著者Blocquel, D., Yang, X.L.
登録日2016-09-29
公開日2017-05-17
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.959 Å)
主引用文献Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5THL
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CRYSTAL STRUCTURE OF THE HUMAN TYROSYL-TRNA SYNTHETASE MUTANT G41R
分子名称:Tyrosine--tRNA ligase, cytoplasmic
著者Blocquel, D., Sajish, M., Yang, X.L.
登録日2016-09-29
公開日2017-06-07
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5W6M
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CRYSTAL STRUCTURE OF THE HUMAN HISTIDYL-TRNA SYNTHETASE MUTANT D175E
分子名称:Histidine--tRNA ligase, cytoplasmic
著者Blocquel, D., Yang, X.L.
登録日2017-06-16
公開日2018-06-20
実験手法X-RAY DIFFRACTION (3.696 Å)
主引用文献Crystal structure of the human histidyl-tRNA synthetase mutant D175E
To Be Published
1B0S
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BINDING OF AR-1-144, A TRI-IMIDAZOLE DNA MINOR GROOVE BINDER, TO CCGG SEQUENCE ANALYZED BY NMR SPECTROSCOPY
分子名称:DNA (5'-D(*GP*AP*AP*CP*CP*GP*GP*TP*TP*C)-3'), (2-{[4-({4-[(4-FORMYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBONYL)-AMINO]-1-METHYL-1H-IMIDAZOLE-2-CARBONYL}-AMINO)-1-METHYL-1H-IMIDAZOLE-2-CARBONYL]-AMINO}-ETHYL)-DIMETHYL-AMMONIUM
著者Yang, X.-L., Kaenzig, C., Lee, M., Wang, A.H.-J.
登録日1998-11-12
公開日1999-08-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Binding of AR-1-144, a tri-imidazole DNA minor groove binder, to CCGG sequence analyzed by NMR spectroscopy.
Eur.J.Biochem., 263, 1999
1BE5
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STRUCTURAL STUDIES OF A STABLE PARALLEL-STRANDED DNA DUPLEX INCORPORATING ISOGUANINE:CYTOSINE AND ISOCYTOSINE:GUANINE BASE PAIRS BY NMR, MINIMIZED AVERAGE STRUCTURE
分子名称:DNA DUPLEX (TGCACGGACT)
著者Yang, X.-L., Sugiyama, H., Ikeda, S., Saito, I., Wang, A.H.-J.
登録日1998-05-19
公開日1998-08-12
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy.
Biophys.J., 75, 1998
1FD5
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BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (BISACRIDINE COMPLEX)
分子名称:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, MACROCYCLIC-BIS-9-AMINO-ACRIDINE, ...
著者Yang, X.-L., Robinson, H., Gao, Y.-G., Wang, A.H.-J.
登録日2000-07-19
公開日2000-08-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
1FDG
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BINDING OF A MACROCYCLIC BISACRIDINE AND AMETANTRONE TO CGTACG INVOLVES SIMILAR UNUSUAL INTERCALATION PLATFORMS (AMETANTRONE COMPLEX)
分子名称:DNA (5'-D(*CP*GP*TP*AP*CP*G)-3'), COBALT (II) ION, 1,4-BIS-[2-(2-HYDROXY-ETHYLAMINO)-ETHYLAMINO]-ANTHRAQUINONE, ...
著者Yang, X.-L., Robinson, H., Gao, Y.-G., Wang, A.H.-J.
登録日2000-07-20
公開日2000-08-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Binding of a macrocyclic bisacridine and ametantrone to CGTACG involves similar unusual intercalation platforms.
Biochemistry, 39, 2000
3VBB
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CRYSTAL STRUCTURE OF SERYL-TRNA SYNTHETASE FROM HUMAN AT 2.9 ANGSTROMS
分子名称:Seryl-tRNA synthetase, cytoplasmic, MAGNESIUM ION, ...
著者Xu, X.L., Yang, X.-L.
登録日2012-01-02
公開日2012-02-29
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (2.891 Å)
主引用文献Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Nat Commun, 3, 2012
6AJF
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS
分子名称:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside
著者Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
登録日2018-08-27
公開日2018-12-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.698 Å)
主引用文献Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJG
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH SQ109
分子名称:Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ...
著者Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
登録日2018-08-27
公開日2018-12-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.604 Å)
主引用文献Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJH
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH AU1235
分子名称:Drug exporters of the RND superfamily-like protein,Endolysin, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
著者Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
登録日2018-08-27
公開日2018-12-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.818 Å)
主引用文献Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJI
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH RIMONABANT
分子名称:Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
著者Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
登録日2018-08-27
公開日2018-12-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJJ
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH ICA38
分子名称:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
著者Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
登録日2018-08-27
公開日2018-12-26
最終更新日2019-02-13
実験手法X-RAY DIFFRACTION (2.794 Å)
主引用文献Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
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