Author results

6BWW
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CRYSTAL STRUCTURE OF AN ACETATE AND CYMAL-5 BOUND CYTOCHROME P450 2B4 F429H MUTANT
Descriptor:Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ...
Authors:Yang, Y.T., Waskell, L.
Deposit date:2017-12-15
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Acetate-bound active site of cytochrome P450 2B4 F429H revealed a water network
To Be Published
1MJN
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CRYSTAL STRUCTURE OF THE INTERMEDIATE AFFINITY AL I DOMAIN MUTANT
Descriptor:Integrin alpha-L, MAGNESIUM ION
Authors:Shimaoka, M., Xiao, T., Liu, J.H., Yang, Y.T., Dong, Y.C., Jun, C.D., McCormack, A., Zhang, R.G., Wang, J.H., Springer, T.A.
Deposit date:2002-08-28
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation
Cell(Cambridge,Mass.), 112, 2003
1NPE
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CRYSTAL STRUCTURE OF NIDOGEN/LAMININ COMPLEX
Descriptor:nidogen, Laminin gamma-1 chain, CADMIUM ION
Authors:Takagi, J., Yang, Y.T., Liu, J.-H., Wang, J.-H., Springer, T.A.
Deposit date:2003-01-17
Release date:2003-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface
Nature, 424, 2003
1SJ0
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH THE ANTAGONIST LIGAND 4-D
Descriptor:Estrogen receptor, (2S,3R)-2-(4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENYL)-2,3-DIHYDRO-3-(4-HYDROXYPHENYL)BENZO[B][1,4]OXATHIIN-6-OL
Authors:Kim, S., Wu, J.Y., Birzin, E.T., Chan, W., Pai, L.Y., Yang, Y.T., Mosley, R.T., Fitzgerald, P.M., Sharma, N., DiNinno, F., Rohrer, S.P., Schaeffer, J.M., Hammond, M.L.
Deposit date:2004-03-02
Release date:2004-04-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Estrogen Receptor Ligands. II. Discovery of Benzoxathiins as Potent, Selective Estrogen Receptor alpha Modulators.
J.Med.Chem., 47, 2004
3DBQ
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CRYSTAL STRUCTURE OF TTK KINASE DOMAIN
Descriptor:Dual specificity protein kinase TTK
Authors:Wang, W., Yang, Y.T., Gao, Y.F., Zhu, S.C., Wang, F., Old, W., Xu, Q.B., Resing, K., Ahn, N., Lei, M., Liu, X.D.
Deposit date:2008-06-02
Release date:2009-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Mechanistic Insights into Mps1 Kinase Activation
J.CELL.MOL.MED., 13, 2008
3X0T
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CRYSTAL STRUCTURE OF PIRA
Descriptor:Uncharacterized protein, NITRATE ION
Authors:Wang, H.C., Ko, T.P., Wang, A.H.J., Lo, C.F.
Deposit date:2014-10-22
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin
Proc.Natl.Acad.Sci.USA, 2015
3X0U
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CRYSTAL STRUCTURE OF PIRB
Descriptor:Uncharacterized protein
Authors:Wang, H.C., Ko, T.P., Wang, A.H.J., Lo, C.F.
Deposit date:2014-10-22
Release date:2015-08-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin
Proc.Natl.Acad.Sci.USA, 2015
3L82
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X-RAY CRYSTAL STRUCTURE OF TRF1 AND FBX4 COMPLEX
Descriptor:Telomeric repeat-binding factor 1, F-box only protein 4
Authors:Zeng, Z.X., Wang, W., Yang, Y.T., Chen, Y., Yang, X.M., Diehl, J.A., Liu, X.D., Lei, M.
Deposit date:2009-12-29
Release date:2010-03-09
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4)
Dev.Cell, 18, 2010
1T0P
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STRUCTURAL BASIS OF ICAM RECOGNITION BY INTEGRIN ALPAHLBETA2 REVEALED IN THE COMPLEX STRUCTURE OF BINDING DOMAINS OF ICAM-3 AND ALPHALBETA2 AT 1.65 A
Descriptor:Integrin alpha-L, Intercellular adhesion molecule-3, MAGNESIUM ION, ...
Authors:Song, G., Yang, Y.T., Liu, J.H., Shimaoko, M., Springer, T.A., Wang, J.H.
Deposit date:2004-04-12
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2.
Proc.Natl.Acad.Sci.Usa, 102, 2005
2HKO
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CRYSTAL STRUCTURE OF LSD1
Descriptor:Lysine-specific histone demethylase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Chen, Y., Yang, Y.T., Wang, F., Yanane, K., Zhang, Y., Lei, M.
Deposit date:2006-07-05
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103, 2006
2I46
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CRYSTAL STRUCTURE OF HUMAN TPP1
Descriptor:Adrenocortical dysplasia protein homolog
Authors:Wang, F., Podell, E.R., Zaug, A.J., Yang, Y.T., Baciu, P., Else, T., Hammer, G.D., Cech, T.R., Lei, M.
Deposit date:2006-08-21
Release date:2006-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The POT1-TPP1 telomere complex is a telomerase processivity factor.
Nature, 445, 2007
3K6G
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CRYSTAL STRUCTURE OF RAP1 AND TRF2 COMPLEX
Descriptor:Telomeric repeat-binding factor 2-interacting protein 1, Telomeric repeat-binding factor 2
Authors:Chen, Y., Rai, R., Yang, Y.T., Zheng, H., Chang, S., Lei, M.
Deposit date:2009-10-08
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011
3KEY
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CRYSTAL STRUCTURE OF S. CEREVISIAE STN1 C-TERMINAL
Descriptor:Protein STN1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3KF6
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CRYSTAL STRUCTURE OF S. POMBE STN1-TEN1 COMPLEX
Descriptor:Protein stn1, Protein ten1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
3KF8
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CRYSTAL STRUCTURE OF C. TROPICALIS STN1-TEN1 COMPLEX
Descriptor:Protein stn1, Protein ten1
Authors:Sun, J., Yu, E.Y., Yang, Y.T., Confer, L.A., Sun, S.H., Wan, K., Lue, N.F., Lei, M.
Deposit date:2009-10-27
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Genes Dev., 23, 2009
1XP1
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15
Descriptor:Estrogen receptor, (2S,3R)-2-(4-{2-[(3R,4R)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2004-10-07
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
1XP6
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16
Descriptor:Estrogen receptor, (2S,3R)-2-(4-{2-[(3S,4S)-3,4-DIMETHYLPYRROLIDIN-1-YL]ETHOXY}PHENYL)-3-(4-HYDROXYPHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2004-10-08
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
1XP9
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18
Descriptor:Estrogen receptor, (2S,3R)-3-(4-HYDROXYPHENYL)-2-(4-{[(2S)-2-PYRROLIDIN-1-YLPROPYL]OXY}PHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2004-10-08
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
1XPC
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 19
Descriptor:Estrogen receptor, (2S,3R)-3-(4-HYDROXYPHENYL)-2-(4-{[(2R)-2-PYRROLIDIN-1-YLPROPYL]OXY}PHENYL)-2,3-DIHYDRO-1,4-BENZOXATHIIN-6-OL
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2004-10-08
Release date:2004-12-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Bioorg.Med.Chem.Lett., 15, 2005
1YIM
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 4
Descriptor:Estrogen receptor, (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL
Authors:Fitzgerald, P.M., Sharma, N.
Deposit date:2005-01-12
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorg.Med.Chem.Lett., 15, 2005
1YIN
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 3F
Descriptor:Estrogen receptor, (2R,3R,4S)-5-FLUORO-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL
Authors:Fitzgerald, P.M., Sharma, N.
Deposit date:2005-01-12
Release date:2005-07-26
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Bioorg.Med.Chem.Lett., 15, 2005
2IOG
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 11F
Descriptor:Estrogen receptor, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-[2-PHENYL-6-(2-PIPERIDIN-1-YLETHOXY)-1H-INDOL-3-YL]ACETAMIDE
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2006-10-10
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha
Bioorg.Med.Chem.Lett., 17, 2007
2IOK
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HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 1D
Descriptor:Estrogen receptor, N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
Authors:Fitzgerald, P.M.D., Sharma, N.
Deposit date:2006-10-10
Release date:2007-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Estrogen receptor ligands. Part 16: 2-Aryl indoles as highly subtype selective ligands for ERalpha
Bioorg.Med.Chem.Lett., 17, 2007