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6PMD
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ACYLDEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, SHV-WFP-SER-PRO-YCP-ALA-MP8 Acyldepsipeptide, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2019-07-01
Release date:2019-11-06
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 5, 2019
6PKA
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STRUCTURE OF CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH UREADEPSIPEPTIDE
Descriptor:ATP-dependent Clp protease proteolytic subunit, OO1-WFP-SER-PRO-YCP-ALA-MP8 ureadepsipeptide
Authors:Griffith, E.C., Lee, R.E.
Deposit date:2019-06-28
Release date:2019-11-06
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Ureadepsipeptides as ClpP Activators.
Acs Infect Dis., 5, 2019
6PEH
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CRYSTAL STRUCTURE OF RABBIT MONOCLONAL ANTI-HIV ANTIBODY 1C2
Descriptor:1C2 Fab Heavy Chain, 1C2 Fab Light Chain, SULFATE ION
Authors:Liban, T., Pancera, M.
Deposit date:2019-06-20
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.296 Å)
Cite:Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability
Immunity, 2019
6P65
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HIV ENV 16055 NFL TD 2CC+ IN COMPLEX WITH ANTIBODY 1C2 FRAGMENT ANTIGEN BINDING
Descriptor:HIV Env 16055 NFL TD 2CC+, Rabbit antibody 1C2 heavy chain fragment antigen binding, Rabbit antibody 1C2 kappa chain, ...
Authors:Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2019-05-31
Release date:2019-11-20
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Vaccine-elicited cross-neutralizing HIV antibodies directed to multiple sites of Env vulnerability following heterologous NFL trimer-liposome prime:boosting
Immunity, 2019
6P62
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HIV ENV BG505 NFL TD+ IN COMPLEX WITH ANTIBODY E70 FRAGMENT ANTIGEN BINDING
Descriptor:HIV-1 Env BG505 NFL TD+, Rabbit monoclonal antibody E70 heavy chain fragment antigen binding, Rabbit monoclonal antibody E70 kappa chain, ...
Authors:Ozorowski, G., Torres, J.L., Ward, A.B.
Deposit date:2019-05-31
Release date:2019-11-20
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Vaccine-elicited cross-neutralizing HIV antibodies directed to multiple sites of Env vulnerability following heterologous NFL trimer-liposome prime:boosting
Immunity, 2019
6NEF
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OUTER MEMBRANE CYTOCHROME S FILAMENT FROM GEOBACTER SULFURREDUCENS
Descriptor:C-type cytochrome OmcS, HEME C, MAGNESIUM ION
Authors:Filman, D.J., Marino, S.F., Ward, J.E., Yang, L., Mester, Z., Bullitt, E., Lovley, D.R., Strauss, M.
Deposit date:2018-12-17
Release date:2019-07-03
Last modified:2019-09-11
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.
Commun Biol, 2, 2019
6N47
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THE STRUCTURE OF SB-2-204-TUBULIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Arnst, K., Banerjee, S., Wang, Y., Li, W., Miller, D., Li, W.
Deposit date:2018-11-17
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:X-Ray Crystal Structure Guided Discovery and Antitumor Efficacy of Dihydroquinoxalinone as Potent Tubulin Polymerization Inhibitors
To Be Published
6JN2
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CRYSTAL STRUCTURE OF THE COILED-COIL DOMAINS OF HUMAN DOT1L IN COMPLEX WITH AF10
Descriptor:Protein AF-10, Histone-lysine N-methyltransferase, H3 lysine-79 specific
Authors:Song, X., Wang, M., Yang, N., Xu, R.M.
Deposit date:2019-03-13
Release date:2019-09-18
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6J3L
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SOLUTION STRUCTURE OF THE N-TERMINAL EXTENDED PROTUBERANT DOMAIN OF EUKARYOTIC RIBOSOMAL STALK PROTEIN P0
Descriptor:60S acidic ribosomal protein P0
Authors:Choi, K.H.A., Lee, K.M., Yang, L., Wing-Heng Yu, C., Banfield, D.K., Ito, K., Uchiumi, T., Wong, K.B.
Deposit date:2019-01-04
Release date:2019-09-04
Last modified:2019-09-25
Method:SOLUTION NMR
Cite:Structural and Mutagenesis Studies Evince the Role of the Extended Protuberant Domain of Ribosomal Protein uL10 in Protein Translation.
Biochemistry, 58, 2019
6J21
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6J20
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CRYSTAL STRUCTURE OF THE HUMAN NK1 SUBSTANCE P RECEPTOR
Descriptor:Substance-P receptor,Endolysin, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Authors:Chen, S., Lu, M., Zhang, H., Wu, B., Zhao, Q.
Deposit date:2018-12-30
Release date:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
6CDP
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VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP20.01 Fab heavy chain, vFP20.01 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDO
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP16.02 Fab heavy chain, vFP16.02 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDM
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP7.04 heavy chain, vFP7.04 light chain, HIV fusion peptide (512-519)
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDI
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CRYO-EM STRUCTURE AT 3.6 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:Glycoprotein gp41, Glycoprotein 120, PGT122 Light Chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6BS2
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 8B
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-12-01
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BRY
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 6A
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-12-01
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BRF
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4B
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-30
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BR1
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TUBULIN-RB3_SLD-TTL IN COMPLEX WITH HETEROCYCLIC PYRIMIDINE COMPOUND 4A
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Kumar, G., Wang, Y., Li, W., White, S.W.
Deposit date:2017-11-29
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61, 2018
6BG5
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STRUCTURE OF 1-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)-1-(1-PROPYLPIPERIDIN-4-YL)-3-(3-(TRIFLUOROMETHYL)PHENYL)UREA BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6BG3
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STRUCTURE OF (3S,4S)-1-BENZYL-4-(3-(3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PIPERIDIN-3-YL ACETATE BOUND TO DCN1
Descriptor:Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea
Authors:Guy, R.K., Schulman, B.A., Scott, D.C., Hammill, J.T.
Deposit date:2017-10-27
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.
J. Med. Chem., 61, 2018
6AJ9
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5 AND 11G1
Descriptor:VL of Fab 11G1, VH of Fab 11G1, VL of Fab 15C5, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ7
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THE STRUCTURE OF ENTEROVIRUS D68 MATURE VIRION IN COMPLEX WITH FAB 15C5
Descriptor:VL of Fab 15C5, VH of Fab 15C5, Capsid protein VP1, ...
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-27
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019
6AJ3
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THE STRUCTURE OF ENTEROVIRUS D68 PROCAPSID
Descriptor:Capsid protein VP1, Capsid protein VP2, Capsid protein VP3
Authors:Zheng, Q.B., Zhu, R., Xu, L.F., He, M.Z., Yan, X.D., Cheng, T., Li, S.W.
Deposit date:2018-08-26
Release date:2018-11-07
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization
Nat Microbiol, 4, 2019