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2BN6
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BU of 2bn6 by Molmil
P-Element Somatic Inhibitor Protein
Descriptor: PSI
Authors:Ignjatovic, T, Yang, J.C, Butler, P.J.G, Neuhaus, D, Nagai, K.
Deposit date:2005-03-21
Release date:2005-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Basis of the Interaction between P-Element Somatic Inhibitor and U1-70K Essential for the Alternative Splicing of P-Element Transposase.
J.Mol.Biol., 351, 2005
2IGG
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BU of 2igg by Molmil
DETERMINATION OF THE SOLUTION STRUCTURES OF DOMAINS II AND III OF PROTEIN G FROM STREPTOCOCCUS BY 1H NMR
Descriptor: PROTEIN G
Authors:Lian, L.-Y, Derrick, J.P, Sutcliffe, M.J, Yang, J.C, Roberts, G.C.K.
Deposit date:1992-08-26
Release date:1994-01-31
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance.
J.Mol.Biol., 228, 1992
2IGH
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BU of 2igh by Molmil
DETERMINATION OF THE SOLUTION STRUCTURES OF DOMAINS II AND III OF PROTEIN G FROM STREPTOCOCCUS BY 1H NMR
Descriptor: PROTEIN G
Authors:Lian, L.-Y, Derrick, J.P, Sutcliffe, M.J, Yang, J.C, Roberts, G.C.K.
Deposit date:1992-08-26
Release date:1994-01-31
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Determination of the solution structures of domains II and III of protein G from Streptococcus by 1H nuclear magnetic resonance.
J.Mol.Biol., 228, 1992
7AAB
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BU of 7aab by Molmil
Crystal structure of the catalytic domain of human PARP1 in complex with inhibitor EB-47
Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION
Authors:Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D.
Deposit date:2020-09-04
Release date:2021-01-13
Last modified:2021-03-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
7AAA
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BU of 7aaa by Molmil
Crystal structure of the catalytic domain of human PARP1 (apo)
Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Poly [ADP-ribose] polymerase 1, ...
Authors:Schimpl, M, Ogden, T.E.H, Yang, J.-C, Underwood, E, Rawlins, P.B, Johannes, J.W, Easton, L.E, Embrey, K.J, Neuhaus, D.
Deposit date:2020-09-04
Release date:2021-01-13
Last modified:2021-03-10
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
7AAC
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BU of 7aac by Molmil
Crystal structure of the catalytic domain of human PARP1 in complex with veliparib
Descriptor: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, Poly [ADP-ribose] polymerase 1, SULFATE ION
Authors:Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D.
Deposit date:2020-09-04
Release date:2021-01-13
Last modified:2021-03-10
Method:X-RAY DIFFRACTION (1.593 Å)
Cite:Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
7AAD
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BU of 7aad by Molmil
Crystal structure of the catalytic domain of human PARP1 in complex with olaparib
Descriptor: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one, Poly [ADP-ribose] polymerase 1, SULFATE ION
Authors:Schimpl, M, Ogden, T.E.H, Yang, J.-C, Easton, L.E, Underwood, E, Rawlins, P.B, Johannes, J.W, Embrey, K.J, Neuhaus, D.
Deposit date:2020-09-04
Release date:2021-01-13
Last modified:2021-03-10
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
Nucleic Acids Res., 49, 2021
5NR6
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BU of 5nr6 by Molmil
NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoidans MATB protein S71A mutant
Descriptor: MatB protein
Authors:Neuhaus, D, Hedgethorne, K, Yang, J.-C.
Deposit date:2017-04-22
Release date:2017-09-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Homeodomain-like DNA binding proteins control the haploid-to-diploid transition in Dictyostelium.
Sci Adv, 3, 2017
5NR5
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BU of 5nr5 by Molmil
NMR structure and 1H, 13C and 15N signal assignments for Dictyostelium discoideum MATA protein
Descriptor: MatA protein
Authors:Neuhaus, D, Hedgethorne, K, Yang, J.-C.
Deposit date:2017-04-22
Release date:2017-09-20
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Homeodomain-like DNA binding proteins control the haploid-to-diploid transition in Dictyostelium.
Sci Adv, 3, 2017
6RH6
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BU of 6rh6 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 PHear domain with phosphorylated AP2 mu2 148-163
Descriptor: AP-2 complex subunit mu, Adaptin ear-binding coat-associated protein 1
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T.
Deposit date:2019-04-18
Release date:2019-09-04
Method:SOLUTION NMR
Cite:Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
6RH5
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BU of 6rh5 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for NECAP1 PHear domain
Descriptor: Adaptin ear-binding coat-associated protein 1
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T.
Deposit date:2019-04-18
Release date:2019-09-04
Method:SOLUTION NMR
Cite:Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
6TL0
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BU of 6tl0 by Molmil
Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of VPS29 with VARP 687-747
Descriptor: Ankyrin repeat domain-containing protein 27, Vacuolar protein sorting-associated protein 29, ZINC ION
Authors:Owen, D.J, Neuhaus, D, Yang, J.-C, Crawley-Snowdon, H.
Deposit date:2019-11-29
Release date:2020-10-21
Method:SOLUTION NMR
Cite:Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.
Nat Commun, 11, 2020
5M1S
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BU of 5m1s by Molmil
Cryo-EM structure of the E. coli replicative DNA polymerase-clamp-exonuclase-theta complex bound to DNA in the editing mode
Descriptor: DNA Primer Strand, DNA Template Strand, DNA polymerase III subunit alpha, ...
Authors:Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H.
Deposit date:2016-10-10
Release date:2017-01-18
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Self-correcting mismatches during high-fidelity DNA replication.
Nat. Struct. Mol. Biol., 24, 2017
5OLM
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BU of 5olm by Molmil
TRIM21
Descriptor: E3 ubiquitin-protein ligase TRIM21, ZINC ION
Authors:James, L.C.
Deposit date:2017-07-28
Release date:2018-04-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Elife, 7, 2018
6QH7
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BU of 6qh7 by Molmil
AP2 clathrin adaptor mu2T156-phosphorylated core with two cargo peptides in open+ conformation
Descriptor: ADAPTOR-RELATED PROTEIN COMPLEX 2, MU 2 SUBUNIT, C-TERMINAL DOMAIN, ...
Authors:Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R.
Deposit date:2019-01-15
Release date:2019-09-04
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
6S53
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BU of 6s53 by Molmil
Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ...
Authors:Kiss, L, Boland, A, Neuhaus, D, James, L.C.
Deposit date:2019-06-30
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases.
Nat Commun, 10, 2019
6TX3
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BU of 6tx3 by Molmil
HPF1 bound to catalytic fragment of PARP2
Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2,Poly [ADP-ribose] polymerase 2
Authors:Suskiewicz, M.J, Ahel, I.
Deposit date:2020-01-13
Release date:2020-02-19
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
6TX1
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BU of 6tx1 by Molmil
HPF1 from Nematostella vectensis
Descriptor: Predicted protein
Authors:Suskiewicz, M.J, Ahel, I.
Deposit date:2020-01-13
Release date:2020-02-19
Last modified:2020-04-08
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.
Nature, 579, 2020
8A58
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BU of 8a58 by Molmil
X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W
Descriptor: E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 W, ZINC ION
Authors:James, L.C, Kiss, L.
Deposit date:2022-06-14
Release date:2023-04-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Nat Commun, 14, 2023
1HF9
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BU of 1hf9 by Molmil
C-Terminal Coiled-Coil Domain from Bovine IF1
Descriptor: ATPASE INHIBITOR (MITOCHONDRIAL)
Authors:Gordon-Smith, D.J, Carbajo, R.J, Yang, J.-C, Videler, H, Runswick, M.J, Walker, J.E, Neuhaus, D.
Deposit date:2000-11-30
Release date:2001-05-31
Last modified:2020-01-15
Method:SOLUTION NMR
Cite:Solution structure of a C-terminal coiled-coil domain from bovine IF(1): the inhibitor protein of F(1) ATPase.
J. Mol. Biol., 308, 2001
8UV0
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BU of 8uv0 by Molmil
Discovery of (4-Pyrazolyl)-2-Aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Descriptor: 1-{(4M)-4-[2-{[1-(cyclopropanesulfonyl)piperidin-4-yl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]-1H-pyrazol-1-yl}-2-methylpropan-2-ol, Cyclin-dependent kinase 2
Authors:Deller, M.C, Epling, L.B.
Deposit date:2023-11-02
Release date:2024-02-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2.
J.Med.Chem., 67, 2024
3ZWL
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BU of 3zwl by Molmil
Structure of eukaryotic translation initiation factor eIF3i complex with eIF3b C-terminus (655-700)
Descriptor: EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B, EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I
Authors:Daujotyte, D, Lukavsky, P.J.
Deposit date:2011-08-01
Release date:2011-10-05
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Analysis of an Eif3 Subcomplex Reveals Conserved Interactions Required for a Stable and Proper Translation Pre-Initiation Complex Assembly.
Nucleic Acids Res., 40, 2012
2XTE
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BU of 2xte by Molmil
Structure of the TBL1 tetramerisation domain
Descriptor: F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J, Fairall, L, Watson, P.J, Greenwood, J.A, Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
2XTC
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BU of 2xtc by Molmil
Structure of the TBL1 tetramerisation domain
Descriptor: F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J, Fairall, L, Watson, P.J, Greenwood, J.A, Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011
2XTD
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BU of 2xtd by Molmil
Structure of the TBL1 tetramerisation domain
Descriptor: TBL1 F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1X
Authors:Oberoi, J, Fairall, L, Watson, P.J, Greenwood, J.A, Schwabe, J.W.R.
Deposit date:2010-10-06
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for the Assembly of the Smrt/Ncor Core Transcriptional Repression Machinery.
Nat.Struct.Mol.Biol., 18, 2011

 

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