Author results

5EGI
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STRUCTURE OF A TRIMERIC INTRACELLULAR CATION CHANNEL FROM C. ELEGANS WITH BOUND CA2+
Descriptor:Uncharacterized protein Y57A10A.10, (1S)-2-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate, CALCIUM ION, ...
Authors:Yang, H.T., Hu, M.H., Liu, Z.F.
Deposit date:2015-10-27
Release date:2016-10-05
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Pore architecture of TRIC channels and insights into their gating mechanism.
Nature, 538, 2016
5EIK
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STRUCTURE OF A TRIMERIC INTRACELLULAR CATION CHANNEL FROM C. ELEGANS IN THE ABSENCE OF CA2+
Descriptor:Uncharacterized protein Y57A10A.28, (1S)-2-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (8E,11E)-icosa-5,8,11,14-tetraenoate, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
Authors:Hu, M.H., Yang, H.T., Liu, Z.F.
Deposit date:2015-10-30
Release date:2016-10-05
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Pore architecture of TRIC channels and insights into their gating mechanism.
Nature, 538, 2016
5GJB
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ZIKA VIRUS NS3 HELICASE IN COMPLEX WITH SSRNA
Descriptor:NS3 helicase, RNA (5'-R(*AP*GP*AP*UP*CP*AP*A)-3')
Authors:Tian, H.L., Ji, X.Y., Yang, X.Y., Zhang, Z.X., Lu, Z.K., Yang, K.L., Chen, C., Zhao, Q., Chi, H., Mu, Z.Y., Xie, W., Wang, Z.F., Lou, H.Q., Yang, H.T., Rao, Z.H.
Deposit date:2016-06-28
Release date:2016-07-20
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Structural basis of Zika virus helicase in recognizing its substrates
Protein Cell, 7, 2016
5GJC
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ZIKA VIRUS NS3 HELICASE IN COMPLEX WITH ATP
Descriptor:NS3 helicase, MANGANESE (II) ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Tian, H.L., Ji, X.Y., Yang, X.Y., Zhang, Z.X., Lu, Z.K., Yang, K.L., Chen, C., Zhao, Q., Chi, H., Mu, Z.Y., Xie, W., Wang, Z.F., Lou, H.Q., Yang, H.T., Rao, Z.H.
Deposit date:2016-06-28
Release date:2016-07-20
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Structural basis of Zika virus helicase in recognizing its substrates
Protein Cell, 7, 2016
5WTR
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CRYSTAL STRUCTURE OF A PROKARYOTIC TRIC CHANNEL IN 0.5 M KCL
Descriptor:Uncharacterized protein, 1,2-ETHANEDIOL, POTASSIUM ION, ...
Authors:Ou, X.M., Wang, L.F., Yang, H.T., Liu, X.Y., Liu, Z.F.
Deposit date:2016-12-14
Release date:2017-04-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ion and water binding sites inside an occluded hourglass pore of a TRIC channel
BMC BIOL., 2017
6AJF
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJG
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH SQ109
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJH
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH AU1235
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJI
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH RIMONABANT
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJJ
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH ICA38
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
5Y6M
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ZIKA VIRUS HELICASE IN COMPLEX WITH ADP-ALF3
Descriptor:Helicase domain from Genome polyprotein, MANGANESE (II) ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Yang, X.Y., Chen, C., Tian, H.L., Chi, H., Mu, Z.Y., Zhang, T.Q., Yang, K.L., Zhao, Q., Liu, X.H., Wang, Z.F., Ji, X.Y., Yang, H.T.
Deposit date:2017-08-12
Release date:2018-07-04
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Mechanism of ATP hydrolysis by the Zika virus helicase.
FASEB J., 32, 2018
5Y6N
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ZIKA VIRUS HELICASE IN COMPLEX WITH ADP
Descriptor:Helicase domain from Genome polyprotein, MANGANESE (II) ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Yang, X.Y., Chen, C., Tian, H.L., Chi, H., Mu, Z.Y., Zhang, T.Q., Yang, K.L., Zhao, Q., Liu, X.H., Wang, Z.F., Ji, X.Y., Yang, H.T.
Deposit date:2017-08-12
Release date:2018-07-04
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (1.571 Å)
Cite:Mechanism of ATP hydrolysis by the Zika virus helicase.
FASEB J., 32, 2018
6JYJ
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CRYSTAL STRUCTURE OF FAM46B (TENT5B)
Descriptor:Terminal nucleotidyltransferase 5B, CITRATE ANION
Authors:Zhang, H., Hu, J.L., Gao, S.
Deposit date:2019-04-26
Release date:2020-03-04
Last modified:2020-03-18
Method:X-RAY DIFFRACTION (2.693199 Å)
Cite:FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Nucleic Acids Res., 48, 2020
6KGH
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS (APO-FORM)
Descriptor:Penicillin-binding protein PbpB, COBALT (II) ION, SODIUM ION
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-11
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGS
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS, COMPLEXED WITH MEROPENEM
Descriptor:Penicillin-binding protein PbpB, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, COBALT (II) ION
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.309 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGT
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS, COMPLEXED WITH FAROPENEM
Descriptor:Penicillin-binding protein PbpB, (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, COBALT (II) ION
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.308 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGU
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS, COMPLEXED WITH AZTREONAM
Descriptor:Penicillin-binding protein PbpB, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, COBALT (II) ION
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.106 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGV
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS, COMPLEXED WITH AMOXICILLIN
Descriptor:Penicillin-binding protein PbpB, COBALT (II) ION, 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGW
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CRYSTAL STRUCTURE OF PENICILLIN BINDING PROTEIN 3 (PBP3) FROM MYCOBACTERIUM TUERCULOSIS, COMPLEXED WITH AMPICILLIN
Descriptor:Penicillin-binding protein PbpB, COBALT (II) ION, (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
Authors:Lu, Z.K., Zhang, A.L., Liu, X., Guddat, L., Yang, H.T., Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.407 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
2Q6D
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CRYSTAL STRUCTURE OF INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE
Descriptor:Infectious bronchitis virus (IBV) main protease
Authors:Xue, X.Y., Yang, H.T., Xue, F., Bartlam, M., Rao, Z.H.
Deposit date:2007-06-04
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
J.Virol., 82, 2008
2Q6F
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CRYSTAL STRUCTURE OF INFECTIOUS BRONCHITIS VIRUS (IBV) MAIN PROTEASE IN COMPLEX WITH A MICHAEL ACCEPTOR INHIBITOR N3
Descriptor:Infectious bronchitis virus (IBV) main protease, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE
Authors:Xue, X.Y., Yang, H.T., Xue, F., Bartlam, M., Rao, Z.H.
Deposit date:2007-06-05
Release date:2008-02-12
Last modified:2015-12-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
J.Virol., 82, 2008
2Q6G
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CRYSTAL STRUCTURE OF SARS-COV MAIN PROTEASE H41A MUTANT IN COMPLEX WITH AN N-TERMINAL SUBSTRATE
Descriptor:severe acute respiratory syndrome coronavirus (SARS-CoV), Polypeptide chain
Authors:Xue, X.Y., Yang, H.T., Xue, F., Bartlam, M., Rao, Z.H.
Deposit date:2007-06-05
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.
J.Virol., 82, 2008
4PZ9
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THE NATIVE STRUCTURE OF MYCOBACTERIAL GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE RV2419C
Descriptor:Glucosyl-3-phosphoglycerate phosphatase
Authors:Zhou, W.H., Zheng, Q.Q., Jiang, D.Q., Zhang, W., Zhang, Q.Q., Jin, J., Li, X., Yang, H.T., Shaw, N., Rao, Z.
Deposit date:2014-03-28
Release date:2014-06-11
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
4PZA
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THE COMPLEX STRUCTURE OF MYCOBACTERIAL GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE RV2419C WITH INORGANIC PHOSPHATE
Descriptor:Glucosyl-3-phosphoglycerate phosphatase, PHOSPHATE ION
Authors:Zhou, W.H., Zheng, Q.Q., Jiang, D.Q., Zhang, W., Zhang, Q.Q., Jin, J., Li, X., Yang, H.T., Shaw, N., Rao, Z.
Deposit date:2014-03-29
Release date:2014-06-11
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014
4QIH
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THE STRUCTURE OF MYCOBACTERIAL GLUCOSYL-3-PHOSPHOGLYCERATE PHOSPHATASE RV2419C COMPLEXES WITH VO3
Descriptor:Glucosyl-3-phosphoglycerate phosphatase, VANADATE ION
Authors:Zhou, W.H., Zheng, Q.Q., Jiang, D.Q., Zhang, W., Zhang, Q.Q., Jin, J., Li, X., Yang, H.T., Shaw, N., Rao, Z.
Deposit date:2014-05-30
Release date:2014-06-11
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Mechanism of dephosphorylation of glucosyl-3-phosphoglycerate by a histidine phosphatase
J.Biol.Chem., 289, 2014