Author results

2K7L
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NMR STRUCTURE OF A COMPLEX FORMED BY THE C-TERMINAL DOMAIN OF HUMAN RAP74 AND A PHOSPHORYLATED PEPTIDE FROM THE CENTRAL DOMAIN OF THE FCP1
Descriptor:centFCP1-T584PO4 peptide, General transcription factor IIF subunit 1
Authors:Yang, A., Abbott, K.L., Desjardins, A., Di Lello, P., Omichinski, J.G., Legault, P.
Deposit date:2008-08-13
Release date:2009-06-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase
Biochemistry, 48, 2009
1ZMZ
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SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN (M1-S98) OF HUMAN CENTRIN 2
Descriptor:Centrin-2
Authors:Yang, A., Miron, S., Duchambon, P., Assairi, L., Blouquit, Y., Craescu, C.T.
Deposit date:2005-05-11
Release date:2006-04-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly
Biochemistry, 45, 2006
2A4J
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SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN (T94-Y172) OF THE HUMAN CENTRIN 2 IN COMPLEX WITH A 17 RESIDUES PEPTIDE (P1-XPC) FROM XERODERMA PIGMENTOSUM GROUP C PROTEIN
Descriptor:Centrin 2, 17-mer peptide P1-XPC from DNA-repair protein complementing XP-C cells
Authors:Yang, A., Miron, S., Mouawad, L., Duchambon, P., Blouquit, Y., Craescu, C.T.
Deposit date:2005-06-29
Release date:2005-07-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair.
Biochemistry, 45, 2006
3LD1
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CRYSTAL STRUCTURE OF IBV NSP2A
Descriptor:Replicase polyprotein 1a
Authors:Xu, Y., Cong, L., Wei, L., Fu, J., Chen, C., Yang, A., Tang, H., Bartlam, M., Rao, Z.
Deposit date:2010-01-12
Release date:2011-05-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:IBV nsp2 is an endosome-associated protein and viral pathogenicity factor
To be Published
4APP
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 4 IN COMPLEX WITH (S)-N-(5-(3-BENZYL-1-METHYLPIPERAZINE-4-CARBONYL)-6,6-DIMETHYL-1,4,5, 6-TETRAHYDROPYRROLO(3,4-C)PYRAZOL-3-YL)-3-PHENOXYBENZAMIDE
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 4, N-[6,6-dimethyl-5-[(2S)-4-methyl-2-(phenylmethyl)piperazin-1-yl]carbonyl-2,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]-3-phenoxy-benzamide, GLYCEROL
Authors:Knighton, D.D., Deng, Y.L., Wang, C., Guo, C., McAlpine, I., Zhang, J., Kephart, S., Johnson, M.C., Li, H., Bouzida, D., Yang, A., Dong, L., Marakovits, J., Tikhe, J., Richardson, P., Guo, L.C., Kania, R., Edwards, M.P., Kraynov, E., Christensen, J., Piraino, J., Lee, J., Dagostino, E., Del-Carmen, C., Smeal, T., Murray, B.W.
Deposit date:2012-04-04
Release date:2012-06-06
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Pyrroloaminopyrazoles as Novel Pak Inhibitors.
J.Med.Chem., 55, 2012
5MS2
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CRYSTAL STRUCTURE OF THE LEGIONELLA PNEUMOPHILA EFFECTOR PROTEIN RAVZ IN COMPLEX WITH HUMAN LC3B
Descriptor:Legionella pneumophila effector protein RavZ, Microtubule-associated proteins 1A/1B light chain 3B
Authors:Pantoom, S., Vetter, I.R., Wu, Y.W.
Deposit date:2016-12-30
Release date:2017-04-19
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Elife, 6, 2017
5MS5
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LOW-SALT STRUCTURE OF RAVZ LIR2-FUSED HUMAN LC3B
Descriptor:RavZ,Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION, GLYCEROL
Authors:Pantoom, S., Vetter, I.R., Wu, Y.W.
Deposit date:2016-12-31
Release date:2017-04-19
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Elife, 6, 2017
5MS6
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HIGH-SALT STRUCTURE OF RAVZ LIR2-FUSED HUMAN LC3B
Descriptor:Microtubule-associated proteins 1A/1B light chain 3B
Authors:Pantoom, S., Vetter, I.R., Wu, Y.W.
Deposit date:2016-12-31
Release date:2017-04-19
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Elife, 6, 2017
5MS7
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CRYSTAL STRUCTURE OF THE LEGIONELLA PNEUMOPHILA EFFECTOR PROTEIN RAVZ_20-502
Descriptor:Legionella pneumophila effector protein RavZ, BARIUM ION, GLYCEROL
Authors:Pantoom, S., Vetter, I.R., Wu, Y.W.
Deposit date:2016-12-31
Release date:2017-04-19
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Elife, 6, 2017
5MS8
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CRYSTAL STRUCTURE OF THE LEGIONELLA PNEUMOPHILA EFFECTOR PROTEIN RAVZ_1-487
Descriptor:Legionella pneumophila effector protein RavZ, BARIUM ION, DI(HYDROXYETHYL)ETHER
Authors:Pantoom, S., Vetter, I.R., Wu, Y.W.
Deposit date:2016-12-31
Release date:2017-04-19
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
Elife, 6, 2017
5WBH
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STRUCTURE OF THE FRB DOMAIN OF MTOR BOUND TO A SUBSTRATE RECRUITMENT PEPTIDE OF S6K1
Descriptor:Serine/threonine-protein kinase mTOR, Ribosomal protein S6 kinase beta-1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBU
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CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(ALPHA-HELIX & BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBY
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CRYSTAL STRUCTURE OF MTOR(DELTAN)-MLST8-PRAS40(BETA-STRAND) COMPLEX
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
6BCU
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CRYO-EM STRUCTURE OF THE ACTIVATED RHEB-MTORC1 REFINED TO 3.4 ANGSTROM
Descriptor:Serine/threonine-protein kinase mTOR,Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR,Regulatory-associated protein of mTOR, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-10-20
Release date:2017-12-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
6BCX
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MTORC1 STRUCTURE REFINED TO 3.0 ANGSTROMS
Descriptor:Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Regulatory-associated protein of mTOR, ...
Authors:Pavletich, N.P., Yang, H.
Deposit date:2017-10-20
Release date:2017-12-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBI
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA RAPTOR
Descriptor:Regulatory-associated protein of TOR 1
Authors:Pavletich, N.P., Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBJ
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA RAPTOR IN COMPLEX WITH THE TOS PEPTIDE OF HUMAN 4EBP1
Descriptor:Regulatory-associated protein of TOR 1, Eukaryotic translation initiation factor 4E-binding protein 1
Authors:Pavletich, N.P., Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBK
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA RAPTOR IN COMPLEX WITH THE TOS PEPTIDE OF HUMAN S6K1
Descriptor:Regulatory-associated protein of TOR 1, Ribosomal protein S6 kinase beta-1
Authors:Pavletich, N.P., Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBL
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CRYSTAL STRUCTURE OF THE ARABIDOPSIS THALIANA RAPTOR IN COMPLEX WITH THE TOS PEPTIDE OF HUMAN PRAS40
Descriptor:Regulatory-associated protein of TOR 1, Proline-rich AKT1 substrate 1
Authors:Pavletich, N.P., Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
4U7Z
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MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK1) BOUND TO G805
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, ...
Authors:Robarge, K.D., Ultsch, M.H., Wiesmann, C.
Deposit date:2014-07-31
Release date:2014-09-24
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.805 Å)
Cite:Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg.Med.Chem.Lett., 24, 2014
4U80
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MEK 1 KINASE BOUND TO G799
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, ...
Authors:Ultsch, M.H., Robarge, K.D., Weismann, C.
Deposit date:2014-07-31
Release date:2014-09-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg.Med.Chem.Lett., 24, 2014
4U81
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MEK1 KINASE BOUND TO SMALL MOLECULE INHIBITOR G659
Descriptor:Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, ...
Authors:Robarge, K.D., Ultsch, M.H., Weismann, C.
Deposit date:2014-07-31
Release date:2014-09-24
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg.Med.Chem.Lett., 24, 2014
3OAW
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4-METHYLPTERIDINEONES AS ORALLY ACTIVE AND SELECTIVE PI3K/MTOR DUAL INHIBITORS
Descriptor:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 2-amino-4-methyl-8-(1-methylethyl)-6-(1H-pyrazol-4-yl)pteridin-7(8H)-one
Authors:Knighton, D.R., Greasley, S.E., Rodgers, C.M.-L.
Deposit date:2010-08-05
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:4-methylpteridinones as orally active and selective PI3K/mTOR dual inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
4PZI
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ZINC FINGER REGION OF MLL2 IN COMPLEX WITH CPG DNA
Descriptor:Histone-lysine N-methyltransferase 2B, DNA (5'-D(*GP*CP*CP*AP*CP*CP*GP*GP*TP*GP*GP*C)-3'), ZINC ION, ...
Authors:Chao, X., Tempel, W., Liu, K., Dong, A., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2014-03-31
Release date:2014-06-04
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
4Z3C
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ZINC FINGER REGION OF HUMAN TET3 IN COMPLEX WITH CPG DNA
Descriptor:DNA (5'-D(*GP*CP*CP*AP*AP*CP*GP*TP*TP*GP*GP*C)-3'), Methylcytosine dioxygenase, UNKNOWN ATOM OR ION, ...
Authors:Liu, K., Xu, C., Tempel, W., Dong, A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2015-03-31
Release date:2015-04-29
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 2017
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