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6V65
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BU of 6v65 by Molmil
Crystal structure of KRAS(GMPPNP)-NF1(GRD)-SPRED1 complex
Descriptor: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
Authors:Yan, W, Simanshu, D.K.
Deposit date:2019-12-04
Release date:2020-07-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.763 Å)
Cite:Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
6V6F
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BU of 6v6f by Molmil
Crystal structure of Q61L KRAS(GMPPNP)-NF1(GRD)-SPRED1(EVH1) complex
Descriptor: FORMIC ACID, GTPase KRas, MAGNESIUM ION, ...
Authors:Yan, W, Simanshu, D.K.
Deposit date:2019-12-05
Release date:2020-07-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.542 Å)
Cite:Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.
Cell Rep, 32, 2020
4Y5T
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BU of 4y5t by Molmil
Structure of FtmOx1 apo with metal Iron
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COBALT (II) ION, FE (II) ION, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2015-02-12
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
4Y5S
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BU of 4y5s by Molmil
Structure of FtmOx1 with a-Ketoglutarate as co-substrate
Descriptor: 2-OXOGLUTARIC ACID, COBALT (II) ION, FE (II) ION, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2015-02-12
Release date:2015-11-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.543 Å)
Cite:Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
5TSU
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BU of 5tsu by Molmil
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, METHIONINE, ...
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5TT2
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BU of 5tt2 by Molmil
Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
3SQD
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BU of 3sqd by Molmil
Crystal structure of human PTIP BRCT5/6-gamma H2AX complex
Descriptor: Histone H2A.x, PAX-interacting protein 1
Authors:Yan, W, Shao, Z.H.
Deposit date:2011-07-05
Release date:2011-11-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Crystal structure of human PTIP BRCT5/6-gamma H2AX
To be Published
7X2E
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BU of 7x2e by Molmil
Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail
Descriptor: Cadherin-related family member 2, GLYCEROL, Harmonin
Authors:Yan, W, Chen, G, Li, J.
Deposit date:2022-02-25
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications.
Faseb J., 36, 2022
5V43
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BU of 5v43 by Molmil
Engineered human IgG Fc domain aglyco801
Descriptor: Ig gamma-1 chain C region
Authors:Yan, W, Marshall, N, Zhang, Y.J.
Deposit date:2017-03-08
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
5V4E
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BU of 5v4e by Molmil
Engineered human IgG Fc domain glyco801 (Fc801)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, W, Marshall, N, Zhang, Y.J.
Deposit date:2017-03-09
Release date:2017-06-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.216 Å)
Cite:IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Irani, S, Zhang, J.
Deposit date:2019-05-07
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
5EIG
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BU of 5eig by Molmil
Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
Descriptor: CYSTEINE, Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Zhang, J.
Deposit date:2015-10-29
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
4JWF
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BU of 4jwf by Molmil
Crystal structure of spTrm10(74)-SAH complex
Descriptor: ACETIC ACID, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase
Authors:Yan, W, Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWH
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BU of 4jwh by Molmil
Crystal structure of spTrm10(Full length)-SAH complex
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine(9)-N1)-methyltransferase
Authors:Yan, W, Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWJ
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BU of 4jwj by Molmil
Crystal structure of scTrm10(84)-SAH complex
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ...
Authors:Yan, W, Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWG
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BU of 4jwg by Molmil
Crystal structure of spTrm10(74)
Descriptor: ACETIC ACID, tRNA (guanine(9)-N1)-methyltransferase
Authors:Yan, W, Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
7CKW
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BU of 7ckw by Molmil
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex
Descriptor: (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, W.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CRH
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BU of 7crh by Molmil
Cryo-EM structure of SKF83959 bound dopamine receptor DRD1-Gs signaling complex
Descriptor: (1S)-6-chloranyl-3-methyl-1-(3-methylphenyl)-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Yan, W, Shao, Z.H.
Deposit date:2020-08-13
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKZ
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BU of 7ckz by Molmil
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
Descriptor: 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, Z.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKX
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BU of 7ckx by Molmil
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Descriptor: (1R,3S)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1H-isochromene-5,6-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, Z.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
7CKY
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BU of 7cky by Molmil
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Descriptor: 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, Z.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
6P0Z
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BU of 6p0z by Molmil
Crystal structure of N-acetylated KRAS (2-169) bound to GDP and Mg
Descriptor: ACETYL GROUP, DI(HYDROXYETHYL)ETHER, GTPase KRas, ...
Authors:Dharmaiah, S, Tran, T.H, Yan, W, Simanshu, D.K.
Deposit date:2019-05-17
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.011 Å)
Cite:Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
6BOF
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BU of 6bof by Molmil
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K, Yan, W, Westover, K.D.
Deposit date:2017-11-20
Release date:2019-05-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
8SAI
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BU of 8sai by Molmil
Cryo-EM structure of GPR34-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Yong, X.H, Zhao, C, Yan, W, Shao, Z.H.
Deposit date:2023-04-01
Release date:2023-10-04
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc.Natl.Acad.Sci.USA, 120, 2023
3JU5
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BU of 3ju5 by Molmil
Crystal Structure of Dimeric Arginine Kinase at 1.75-A Resolution
Descriptor: Arginine kinase, MAGNESIUM ION
Authors:Wu, X, Ye, S, Guo, S, Yan, W, Bartlam, M, Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010

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PDB entries from 2024-03-27

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