Author results

6M71
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2019-NCOV RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH COFACTORS
Descriptor:SARS-CoV-2 NSP12, SARS-CoV-2 NSP7, SARS-CoV-2 NSP8
Authors:Gao, Y., Yan, L., Huang, Y., Liu, F., Cao, L., Wang, T., Wang, Q., Lou, Z., Rao, Z.
Deposit date:2020-03-16
Release date:2020-04-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of 2019-nCoV RNA-dependent RNA polymerase in complex with cofactors at 2.9 Angstroms resolution.
To Be Published
6JSJ
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STRUCTURAL ANALYSIS OF A TRIMERIC ASSEMBLY OF THE MITOCHONDRIAL DYNAMIN-LIKE GTPASE MGM1
Descriptor:Dynamin-like GTPase MGM1, mitochondrial, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Yan, L., Li, L.
Deposit date:2019-04-08
Release date:2020-02-19
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PD4
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CRYSTAL STRUCTURE OF HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN
Descriptor:Attachment glycoprotein, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2019-06-18
Release date:2019-11-27
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.
PLoS ONE, 7, 2012
6PDL
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CRYSTAL STRUCTURE OF HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN IN COMPLEX WITH RECEPTOR EPHRIN-B2
Descriptor:Attachment glycoprotein, Ephrin-B2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2019-06-19
Release date:2019-11-27
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2.
PLoS ONE, 7, 2012
6TYS
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A POTENT CROSS-NEUTRALIZING ANTIBODY TARGETING THE FUSION GLYCOPROTEIN INHIBITS NIPAH VIRUS AND HENDRA VIRUS INFECTION
Descriptor:Fusion glycoprotein F0, 5B3 antibody heavy chain, 5B3 antibody light chain, ...
Authors:Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C.E., Broder, C.B., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-09
Release date:2019-10-09
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.
Nat.Struct.Mol.Biol., 26, 2019
6U1T
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CRYSTAL STRUCTURE OF ANTI-NIPAH VIRUS (NIV) F 5B3 ANTIBODY FAB FRAGMENT
Descriptor:antigen-binding (Fab) fragment, heavy chain, light chain, ...
Authors:Dang, H.V., Chan, Y.P., Park, Y.J., Snijder, J., Da Silva, S.C., Vu, B., Yan, L., Feng, Y.R., Rockx, B., Geisbert, T., Mire, C., Mire, C.E., BBroder, C.C., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-08-16
Release date:2019-10-09
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.
Nat.Struct.Mol.Biol., 26, 2019
6JYT
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DELICATE STRUCTURAL COORDINATION OF THE SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS NSP13 UPON ATP HYDROLYSIS
Descriptor:Helicase, ZINC ION
Authors:Yan, L., Jia, Z.
Deposit date:2019-04-28
Release date:2019-09-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Nucleic Acids Res., 47, 2019
6JZE
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CRYSTAL STRUCTURE OF VASH2-SVBP COMPLEX WITH THE MAGIC TRIANGLE I3C
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid
Authors:Chen, Z., Ling, Y., Zeyuan, G., Zhu, L.
Deposit date:2019-05-01
Release date:2019-08-07
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.
Nat Commun, 10, 2019
6JZC
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STRUCTURAL BASIS OF TUBULIN DETYROSINATION
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, GLYCEROL
Authors:Chen, Z., Ling, Y., Zeyuan, G., Zhu, L.
Deposit date:2019-05-01
Release date:2019-07-17
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.
Nat Commun, 10, 2019
6JZD
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CRYSTAL STRUCTURE OF PEPTIDE-BOUND VASH2-SVBP COMPLEX
Descriptor:Tubulinyl-Tyr carboxypeptidase 2, Small vasohibin-binding protein, GLU-GLY-GLU-GLU-TYR
Authors:Chen, Z., Ling, Y., Zeyuan, G., Zhu, L.
Deposit date:2019-05-01
Release date:2019-07-17
Last modified:2019-08-07
Method:X-RAY DIFFRACTION (2.479 Å)
Cite:Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer.
Nat Commun, 10, 2019
6JYL
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THE CROSSLINKED COMPLEX OF ISWI-NUCLEOSOME IN THE ADP.BEF-BOUND STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Yan, L.J., Wu, H., Li, X.M., Gao, N., Chen, Z.C.
Deposit date:2019-04-26
Release date:2019-05-29
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.37 Å)
Cite:Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Nat.Struct.Mol.Biol., 26, 2019
6K1P
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THE COMPLEX OF ISWI-NUCLEOSOME IN THE ADP.BEF-BOUND STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Yan, L.J., Wu, H., Li, X.M., Gao, N., Chen, Z.C.
Deposit date:2019-05-10
Release date:2019-05-29
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Nat.Struct.Mol.Biol., 26, 2019
5ZUV
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CRYSTAL STRUCTURE OF THE HUMAN CORONAVIRUS 229E HR1 MOTIF IN COMPLEX WITH PAN-COVS INHIBITOR EK1
Descriptor:Spike glycoprotein,Spike glycoprotein,inhibitor EK1, CHLORIDE ION
Authors:Yan, L., Yang, B., Wilson, I.A.
Deposit date:2018-05-08
Release date:2019-04-10
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Sci Adv, 5, 2019
5ZVK
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CRYSTAL STRUCTURE OF THE HUMAN CORONAVIRUS MERS HR1 MOTIF IN COMPLEX WITH PAN-COVS INHIBITOR EK1
Descriptor:Human Coronavirus MERS HR1 motif, pan-CoV inhibitory peptide EK1
Authors:Yan, L., Yang, B., Wilson, I.A.
Deposit date:2018-05-11
Release date:2019-04-10
Last modified:2019-08-28
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Sci Adv, 5, 2019
5ZVM
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CRYSTAL STRUCTURE OF THE HUMAN CORONAVIRUS SARS HR1 MOTIF IN COMPLEX WITH PAN-COVS INHIBITOR EK1
Descriptor:Spike glycoprotein, pan-CoV inhibitory peptide EK1
Authors:Yan, L., Yang, B., Wilson, I.A.
Deposit date:2018-05-11
Release date:2019-04-10
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Sci Adv, 5, 2019
6IRO
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THE CROSSLINKED COMPLEX OF ISWI-NUCLEOSOME IN THE ADP-BOUND STATE
Descriptor:ISWI chromatin-remodeling complex ATPase ISW1, Histone H3, Histone H4, ...
Authors:Yan, L.J., Wu, H., Li, X.M., Gao, N., Chen, Z.C.
Deposit date:2018-11-13
Release date:2019-04-03
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Nat. Struct. Mol. Biol., 26, 2019
6BRB
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NOVEL NON-ANTIBODY PROTEIN SCAFFOLD TARGETING CD40L
Descriptor:CD40 ligand, Tn3-like, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Oganesyan, V., Baca, M., Thisted, T., Grinberg, L., Wu, H., Dall'Acqua, W.F.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019
5YEJ
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CRYSTAL STRUCTURE OF BIOQ WITH ITS NATUREL DOUBLE-STRANDED DNA OPERATOR
Descriptor:TetR family transcriptional regulator, DNA (5'-D(*AP*CP*CP*TP*GP*AP*AP*CP*AP*CP*CP*GP*TP*TP*CP*AP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*TP*GP*AP*AP*CP*GP*GP*TP*GP*TP*TP*CP*AP*GP*GP*T)-3')
Authors:Yan, L., Guan, Z.Y., Zou, T.T.
Deposit date:2017-09-17
Release date:2018-09-26
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway.
Biochim Biophys Acta Gen Subj, 1862, 2018
5YEK
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CRYSTAL STRUCTURE OF BIOQ
Descriptor:TetR family transcriptional regulator
Authors:Yan, L., Guan, Z.Y., Zou, T.T.
Deposit date:2017-09-17
Release date:2018-09-26
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.191 Å)
Cite:Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway.
Biochim Biophys Acta Gen Subj, 1862, 2018
5YL9
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1.86 ANGSTROM CRYSTAL STRUCTURE OF HUMAN CORONAVIRUS 229E FUSION CORE
Descriptor:Spike glycoprotein
Authors:Yang, B., Yan, L., Meng, B., WIlson, I.A.
Deposit date:2017-10-17
Release date:2018-09-26
Method:X-RAY DIFFRACTION (1.861 Å)
Cite:Crystal structure of the post-fusion core of the Human coronavirus 229E spike protein at 1.86 angstrom resolution
Acta Crystallogr D Struct Biol, 74, 2018
5YVD
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF ENDORIBONUCLEASE NSP15 ENCODED BY MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS
Descriptor:Nsp15, GLYCEROL
Authors:Yan, L., Zhang, L.
Deposit date:2017-11-24
Release date:2018-08-22
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Biochemical Characterization of Endoribonuclease Nsp15 Encoded by Middle East Respiratory Syndrome Coronavirus.
J. Virol., 92, 2018
5YEW
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STRUCTURAL BASIS FOR GTP HYDROLYSIS AND CONFORMATIONAL CHANGE OF MITOFUSIN 1 IN MEDIATING MITOCHONDRIAL FUSION
Descriptor:Mitofusin-1,Mitofusin-1 fusion protein, GUANOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Yan, L., Qi, Y., Huang, X., Yu, C.
Deposit date:2017-09-20
Release date:2018-01-31
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
Nat. Struct. Mol. Biol., 25, 2018
5WWD
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CRYSTAL STRUCTURE OF ATNUDX1
Descriptor:Nudix hydrolase 1, GLYCEROL, METHOXYETHANE, ...
Authors:Liu, J., Guan, Z., Yan, L., Zou, T., Yin, P.
Deposit date:2016-12-31
Release date:2017-11-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.386 Å)
Cite:Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
Mol Plant, 11, 2018
5WY6
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CRYSTAL STRUCTURE OF ATNUDX1 (E56A)
Descriptor:Nudix hydrolase 1, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Liu, J., Guan, Z., Yan, L., Zou, T., Yin, P.
Deposit date:2017-01-11
Release date:2017-11-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.779 Å)
Cite:Structural Insights into the Substrate Recognition Mechanism of Arabidopsis GPP-Bound NUDX1 for Noncanonical Monoterpene Biosynthesis.
Mol Plant, 11, 2018
5GJK
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CRYSTAL STRUCTURE OF BAF47 AND BAF155 COMPLEX
Descriptor:SWI/SNF complex subunit SMARCC1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, GLYCEROL, ...
Authors:Yan, L., Qian, C.
Deposit date:2016-06-30
Release date:2017-06-07
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:Structural Insights into BAF47 and BAF155 Complex Formation.
J. Mol. Biol., 429, 2017
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