Author results

2CZR
  • Download 2czr
  • View 2czr
Molmil generated image of 2czr
CRYSTAL STRUCTURE OF TBP-INTERACTING PROTEIN (TK-TIP26) AND IMPLICATIONS FOR ITS INHIBITION MECHANISM OF THE INTERACTION BETWEEN TBP AND TATA-DNA
Descriptor:TBP-interacting protein, ZINC ION, GLYCEROL
Authors:Yamamoto, T., Matsuda, T., Inoue, T., Matsumura, H., Morikawa, M., Kanaya, S., Kai, Y.
Deposit date:2005-07-15
Release date:2006-02-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of TBP-interacting protein (Tk-TIP26) and implications for its inhibition mechanism of the interaction between TBP and TATA-DNA
Protein Sci., 15, 2006
5F8B
  • Download 5f8b
  • View 5f8b
Molmil generated image of 5f8b
CRYSTALLOGRAPHIC STRUCTURE OF PSOE WITH CO
Descriptor:Glutathione S-transferase, putative, COBALT (II) ION, ...
Authors:Hara, K., Hashimoto, H., Yamamoto, T., Tsunematsu, Y., Watanabe, K.
Deposit date:2015-12-09
Release date:2016-04-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
5FHI
  • Download 5fhi
  • View 5fhi
Molmil generated image of 5fhi
CRYSTALLOGRAPHIC STRUCTURE OF PSOE WITHOUT CO
Descriptor:Glutathione S-transferase, putative, GLUTATHIONE
Authors:Hara, K., Hashimoto, H., Yamamoto, T., Tsunematsu, Y., Watanabe, K.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis.
Angew. Chem. Int. Ed. Engl., 55, 2016
4X8Y
  • Download 4x8y
  • View 4x8y
Molmil generated image of 4x8y
CRYSTAL STRUCTURE OF HUMAN PGRMC1 CYTOCHROME B5-LIKE DOMAIN
Descriptor:Membrane-associated progesterone receptor component 1, PROTOPORPHYRIN IX CONTAINING FE
Authors:Nakane, T., Yamamoto, T., Shimamura, T., Kobayashi, T., Kabe, Y., Suematsu, M.
Deposit date:2014-12-11
Release date:2016-03-23
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
Nat Commun, 7, 2016
3WIQ
  • Download 3wiq
  • View 3wiq
Molmil generated image of 3wiq
CRYSTAL STRUCTURE OF KOJIBIOSE PHOSPHORYLASE COMPLEXED WITH KOJIBIOSE
Descriptor:Kojibiose phosphorylase, ALPHA-D-GLUCOSE, BETA-D-GLUCOSE, ...
Authors:Okada, S., Yamamoto, T., Watanabe, H., Nishimoto, T., Chaen, H., Fukuda, S., Wakagi, T., Fushinobu, S.
Deposit date:2013-09-24
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and mutational analysis of substrate recognition in kojibiose phosphorylase
Febs J., 281, 2014
3WIR
  • Download 3wir
  • View 3wir
Molmil generated image of 3wir
CRYSTAL STRUCTURE OF KOJIBIOSE PHOSPHORYLASE COMPLEXED WITH GLUCOSE
Descriptor:Kojibiose phosphorylase, BETA-D-GLUCOSE, GLYCEROL, ...
Authors:Okada, S., Yamamoto, T., Watanabe, H., Nishimoto, T., Chaen, H., Fukuda, S., Wakagi, T., Fushinobu, S.
Deposit date:2013-09-24
Release date:2014-02-05
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and mutational analysis of substrate recognition in kojibiose phosphorylase
Febs J., 281, 2014
2E2G
  • Download 2e2g
  • View 2e2g
Molmil generated image of 2e2g
CRYSTAL STRUCTURE OF ARCHAEAL PEROXIREDOXIN, THIOREDOXIN PEROXIDASE FROM AEROPYRUM PERNIX K1 (PRE-OXIDATION FORM)
Descriptor:Probable peroxiredoxin
Authors:Nakamura, T., Yamamoto, T., Abe, M., Matsumura, H., Hagihara, Y., Goto, T., Yamaguchi, T., Inoue, T.
Deposit date:2006-11-13
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
2E2M
  • Download 2e2m
  • View 2e2m
Molmil generated image of 2e2m
CRYSTAL STRUCTURE OF ARCHAEAL PEROXIREDOXIN, THIOREDOXIN PEROXIDASE FROM AEROPYRUM PERNIX K1 (SULFINIC ACID FORM)
Descriptor:Probable peroxiredoxin
Authors:Nakamura, T., Yamamoto, T., Abe, M., Matsumura, H., Hagihara, Y., Goto, T., Yamaguchi, T., Inoue, T.
Deposit date:2006-11-14
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
2NVL
  • Download 2nvl
  • View 2nvl
Molmil generated image of 2nvl
CRYSTAL STRUCTURE OF ARCHAEAL PEROXIREDOXIN, THIOREDOXIN PEROXIDASE FROM AEROPYRUM PERNIX K1 (SULFONIC ACID FORM)
Descriptor:Probable peroxiredoxin
Authors:Nakamura, T., Yamamoto, T., Abe, M., Matsumura, H., Hagihara, Y., Goto, T., Yamaguchi, T., Inoue, T.
Deposit date:2006-11-13
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZCT
  • Download 2zct
  • View 2zct
Molmil generated image of 2zct
OXIDATION OF ARCHAEAL PEROXIREDOXIN INVOLVES A HYPERVALENT SULFUR INTERMEDIATE
Descriptor:Probable peroxiredoxin
Authors:Nakamura, T., Hagihara, Y., Abe, M., Inoue, T., Yamamoto, T., Matsumura, H.
Deposit date:2007-11-12
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate
Proc.Natl.Acad.Sci.Usa, 105, 2008
3VQU
  • Download 3vqu
  • View 3vqu
Molmil generated image of 3vqu
CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2- YL)AMINO]BENZAMIDE
Descriptor:Dual specificity protein kinase TTK, IODIDE ION, 4-[(4-amino-5-cyano-6-ethoxypyridin-2-yl)amino]benzamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Itoh, T., Higashino, K., Okano, Y., Tadano, G., Tachibana, Y., Sato, Y., Inoue, M., Wada, T., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Tagashira, S., Kido, Y., Sakamoto, S., Yasuo, K., Maeda, M., Yamamoto, T., Higaki, M., Endoh, T., Ueda, K., Shiota, T., Murai, H., Nakamura, Y.
Deposit date:2012-03-30
Release date:2012-06-27
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
Acs Med.Chem.Lett., 3, 2012
3W1F
  • Download 3w1f
  • View 3w1f
Molmil generated image of 3w1f
CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 5-(5-ETHOXY-6-(1-METHYL-1H-PYRAZOL-4-YL)-1H-INDAZOL-3-YL)-2-METHYLBENZENESULFONAMIDE
Descriptor:Dual specificity protein kinase TTK, 5-[5-ethoxy-6-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-3-yl]-2-methylbenzenesulfonamide
Authors:Kusakabe, K., Ide, N., Daigo, Y., Tachibana, Y., Itoh, T., Yamamoto, T., Hashizume, H., Hato, Y., Higashino, K., Okano, Y., Sato, Y., Inoue, M., Iguchi, M., Kanazawa, T., Ishioka, Y., Dohi, K., Kido, Y., Sakamoto, S., Yasuo, K., Maeda, M., Higaki, M., Ueda, K., Yoshizawa, H., Baba, Y., Shiota, T., Murai, H., Nakamura, Y.
Deposit date:2012-11-14
Release date:2013-06-26
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)
J.Med.Chem., 56, 2013
3WD0
  • Download 3wd0
  • View 3wd0
Molmil generated image of 3wd0
SERRATIA MARCESCENS CHITINASE B, TETRAGONAL FORM
Descriptor:Chitinase B, GLYCEROL, SULFATE ION, ...
Authors:Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K.B., Omura, S., Sunazuka, T.
Deposit date:2013-06-06
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Proc.Natl.Acad.Sci.USA, 110, 2013
3WD1
  • Download 3wd1
  • View 3wd1
Molmil generated image of 3wd1
SERRATIA MARCESCENS CHITINASE B COMPLEXED WITH SYN-TRIAZOLE INHIBITOR
Descriptor:Chitinase B, GLYCEROL, SULFATE ION, ...
Authors:Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K.B., Omura, S., Sunazuka, T.
Deposit date:2013-06-06
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Proc.Natl.Acad.Sci.USA, 110, 2013
3WD2
  • Download 3wd2
  • View 3wd2
Molmil generated image of 3wd2
SERRATIA MARCESCENS CHITINASE B COMPLEXED WITH AZIDE INHIBITOR
Descriptor:Chitinase B, [2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide, GLYCEROL, ...
Authors:Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K.B., Omura, S., Sunazuka, T.
Deposit date:2013-06-06
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Proc.Natl.Acad.Sci.USA, 110, 2013
3WD3
  • Download 3wd3
  • View 3wd3
Molmil generated image of 3wd3
SERRATIA MARCESCENS CHITINASE B COMPLEXED WITH AZIDE INHIBITOR
Descriptor:Chitinase B, [2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide, GLYCEROL, ...
Authors:Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K.B., Omura, S., Sunazuka, T.
Deposit date:2013-06-06
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Proc.Natl.Acad.Sci.USA, 110, 2013
3WD4
  • Download 3wd4
  • View 3wd4
Molmil generated image of 3wd4
SERRATIA MARCESCENS CHITINASE B COMPLEXED WITH AZIDE INHIBITOR AND QUINOLINE COMPOUND
Descriptor:Chitinase B, GLYCEROL, SULFATE ION, ...
Authors:Hirose, T., Maita, N., Gouda, H., Koseki, J., Yamamoto, T., Sugawara, A., Nakano, H., Hirono, S., Shiomi, K., Watanabe, T., Taniguchi, H., Sharpless, K.B., Omura, S., Sunazuka, T.
Deposit date:2013-06-06
Release date:2013-09-18
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
Proc.Natl.Acad.Sci.USA, 110, 2013
3WZN
  • Download 3wzn
  • View 3wzn
Molmil generated image of 3wzn
CRYSTAL STRUCTURE OF THE CORE STREPTAVIDIN MUTANT V21 (Y22S/N23D/S27D/Y83S/R84K/E101D/R103K/E116N) COMPLEXED WITH BIOTIN AT 1.3 A RESOLUTION
Descriptor:Streptavidin, BIOTIN, SULFATE ION
Authors:Kawato, T., Mizohata, E., Shimizu, Y., Meshizuka, T., Yamamoto, T., Takasu, N., Matsuoka, M., Matsumura, H., Tsumoto, K., Kodama, T., Kanai, M., Doi, H., Inoue, T., Sugiyama, A.
Deposit date:2014-10-01
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-based design of a streptavidin mutant specific for an artificial biotin analogue
J.Biochem., 2015
3WZO
  • Download 3wzo
  • View 3wzo
Molmil generated image of 3wzo
CRYSTAL STRUCTURE OF THE CORE STREPTAVIDIN MUTANT V21 (Y22S/N23D/S27D/Y83S/R84K/E101D/R103K/E116N) COMPLEXED WITH BIOTIN LONG TAIL (BTNTAIL) AT 1.5 A RESOLUTION
Descriptor:Streptavidin, 6-({5-[(3aS,4S,5S,6aR)-5-oxido-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoic acid, GLYCEROL, ...
Authors:Kawato, T., Mizohata, E., Shimizu, Y., Meshizuka, T., Yamamoto, T., Takasu, N., Matsuoka, M., Matsumura, H., Tsumoto, K., Kodama, T., Kanai, M., Doi, H., Inoue, T., Sugiyama, A.
Deposit date:2014-10-01
Release date:2015-02-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based design of a streptavidin mutant specific for an artificial biotin analogue
J.Biochem., 2015
3WZP
  • Download 3wzp
  • View 3wzp
Molmil generated image of 3wzp
CRYSTAL STRUCTURE OF THE CORE STREPTAVIDIN MUTANT V21 (Y22S/N23D/S27D/Y83S/R84K/E101D/R103K/E116N) COMPLEXED WITH IMINOBIOTIN LONG TAIL (IMNTAIL) AT 1.2 A RESOLUTION
Descriptor:Streptavidin, 6-({5-[(2E,3aS,4S,6aR)-2-iminohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoic acid, GLYCEROL
Authors:Kawato, T., Mizohata, E., Shimizu, Y., Meshizuka, T., Yamamoto, T., Takasu, N., Matsuoka, M., Matsumura, H., Tsumoto, K., Kodama, T., Kanai, M., Doi, H., Inoue, T., Sugiyama, A.
Deposit date:2014-10-01
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-based design of a streptavidin mutant specific for an artificial biotin analogue
J.Biochem., 2015
3WZQ
  • Download 3wzq
  • View 3wzq
Molmil generated image of 3wzq
CRYSTAL STRUCTURE OF THE CORE STREPTAVIDIN MUTANT V212 (Y22S/N23D/S27D/S45N/Y83S/R84K/E101D/R103K/E116N) COMPLEXED WITH IMINOBIOTIN LONG TAIL (IMNTAIL) AT 1.7 A RESOLUTION
Descriptor:Streptavidin, 6-({5-[(2E,3aS,4S,6aR)-2-iminohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoic acid, HEXAETHYLENE GLYCOL
Authors:Kawato, T., Mizohata, E., Shimizu, Y., Meshizuka, T., Yamamoto, T., Takasu, N., Matsuoka, M., Matsumura, H., Tsumoto, K., Kodama, T., Kanai, M., Doi, H., Inoue, T., Sugiyama, A.
Deposit date:2014-10-01
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-based design of a streptavidin mutant specific for an artificial biotin analogue
J.Biochem., 2015
3X00
  • Download 3x00
  • View 3x00
Molmil generated image of 3x00
CRYSTAL STRUCTURE OF THE CORE STREPTAVIDIN MUTANT V212 (Y22S/N23D/S27D/S45N/Y83S/R84K/E101D/R103K/E116N) COMPLEXED WITH BIS IMINOBIOTIN LONG TAIL (BIS-IMNTAIL) AT 1.3 A RESOLUTION
Descriptor:Streptavidin, 6-({5-[(2E,3aS,4S,6aR)-2-iminohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanoic acid, ETHANE-1,2-DIAMINE
Authors:Kawato, T., Mizohata, E., Shimizu, Y., Meshizuka, T., Yamamoto, T., Takasu, N., Matsuoka, M., Matsumura, H., Kodama, T., Kanai, M., Doi, H., Inoue, T., Sugiyama, A.
Deposit date:2014-10-09
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure-based design and synthesis of a bivalent iminobiotin analog showing strong affinity toward a low immunogenic streptavidin mutant
Biosci.Biotechnol.Biochem., 2015
6JT4
  • Download 6jt4
  • View 6jt4
Molmil generated image of 6jt4
CRYSTAL STRUCTURE OF BACE1 IN COMPLEX WITH N-{3-[(4S,6S)-2-AMINO-4-METHYL-6-(TRIFLUOROMETHYL)-5,6-DIHYDRO-4H-1,3-THIAZIN-4-YL]-4-FLUOROPHENYL}-5-(FLUOROMETHOXY)PYRAZINE-2-CARBOXAMIDE
Descriptor:Beta-secretase 1, IODIDE ION, GLYCEROL, ...
Authors:Anan, K., Iso, Y., Oguma, T., Nakahara, K., Suzuki, S., Yamamoto, T., Matsuoka, E., Ito, H., Sakaguchi, G., Ando, S., Morimoto, K., Kanegawa, N., Kido, Y., Kawachi, T., Fukushima, T., Teisman, A., Urmaliya, V., Dhuyvetter, D., Borghys, H., Austin, N., Bergh, A.V.D., Verboven, P., Bischoff, F., Gijsen, H.J.M., Yamano, Y., Kusakabe, K.I.
Deposit date:2019-04-08
Release date:2020-01-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden.
Chemmedchem, 14, 2019
1X0R
  • Download 1x0r
  • View 1x0r
Molmil generated image of 1x0r
THIOREDOXIN PEROXIDASE FROM AEROPYRUM PERNIX K1
Descriptor:Probable peroxiredoxin, 1,2-ETHANEDIOL
Authors:Nakamura, T., Yamamoto, T., Inoue, T., Matsumura, H., Kobayashi, A., Hagihara, Y., Uegaki, K., Ataka, M., Kai, Y., Ishikawa, K.
Deposit date:2005-03-28
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of thioredoxin peroxidase from aerobic hyperthermophilic archaeon Aeropyrum pernix K1
Proteins, 62, 2006
2D5R
  • Download 2d5r
  • View 2d5r
Molmil generated image of 2d5r
CRYSTAL STRUCTURE OF A TOB-HCAF1 COMPLEX
Descriptor:CCR4-NOT transcription complex subunit 7, Tob1 protein
Authors:Horiuchi, M., Suzuki, N.N., Muroya, N., Takahasi, K., Nishida, M., Yoshida, Y., Ikematsu, N., Nakamura, T., Kawamura-Tsuzuku, J., Yamamoto, T., Inagaki, F.
Deposit date:2005-11-04
Release date:2006-12-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the antiproliferative activity of the Tob-hCaf1 complex.
J.Biol.Chem., 284, 2009