Author results

1D1Z
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP
分子名称:SAP SH2 DOMAIN, SULFATE ION
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-09-22
公開日1999-10-13
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4T
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH A SLAM PEPTIDE
分子名称:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1D4W
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CRYSTAL STRUCTURE OF THE XLP PROTEIN SAP IN COMPLEX WITH SLAM PHOSPHOPEPTIDE
分子名称:T CELL SIGNAL TRANSDUCTION MOLECULE SAP, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE
著者Poy, F., Yaffe, M.B., Sayos, J., Saxena, K., Eck, M.J.
登録日1999-10-06
公開日1999-10-14
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Mol.Cell, 4, 1999
1GXC
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FHA DOMAIN FROM HUMAN CHK2 KINASE IN COMPLEX WITH A SYNTHETIC PHOSPHOPEPTIDE
分子名称:SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE
著者Li, J., Williams, B.L., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
登録日2002-04-02
公開日2002-06-13
最終更新日2016-12-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
Mol.Cell, 9, 2002
1QJA
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2)
分子名称:14-3-3 PROTEIN ZETA, PHOSPHOPEPTIDE
著者Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1QJB
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14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1)
分子名称:14-3-3 PROTEIN ZETA/DELTA, PHOSPHOPEPTIDE
著者Rittinger, K., Budman, J., Xu, J., Volinia, S., Cantley, L.C., Smerdon, S.J., Gamblin, S.J., Yaffe, M.B.
登録日1999-06-23
公開日1999-09-15
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand Binding
Mol.Cell, 4, 1999
1T15
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CRYSTAL STRUCTURE OF THE BRCA1 BRCT DOMAINS IN COMPLEX WITH THE PHOSPHORYLATED INTERACTING REGION FROM BACH1 HELICASE
分子名称:Breast cancer type 1 susceptibility protein, BRCA1 interacting protein C-terminal helicase 1
著者Clapperton, J.A., Manke, I.A., Lowery, D.M., Ho, T., Haire, L.F., Yaffe, M.B., Smerdon, S.J.
登録日2004-04-15
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
1UMW
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STRUCTURE OF A HUMAN PLK1 POLO-BOX DOMAIN/PHOSPHOPEPTIDE COMPLEX
分子名称:SERINE/THREONINE-PROTEIN KINASE PLK, PEPTIDE
著者Rellos, P., Elia, A., Yaffe, M.B., Smerdon, S.J.
登録日2003-08-29
公開日2003-10-16
最終更新日2017-02-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
Cell(Cambridge,Mass.), 115, 2003
1YWT
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CRYSTAL STRUCTURE OF THE HUMAN SIGMA ISOFORM OF 14-3-3 IN COMPLEX WITH A MODE-1 PHOSPHOPEPTIDE
分子名称:14-3-3 protein sigma, synthetic optimal phosphopeptide (mode-1), CALCIUM ION
著者Wilker, E.W., Grant, R.A., Artim, S.C., Yaffe, M.B.
登録日2005-02-18
公開日2005-03-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A structural basis for 14-3-3sigma functional specificity.
J.Biol.Chem., 280, 2005
2AZM
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CRYSTAL STRUCTURE OF THE MDC1 BRCT REPEAT IN COMPLEX WITH THE HISTONE TAIL OF GAMMA-H2AX
分子名称:Mediator of DNA damage checkpoint protein 1, GAMMA-H2AX HISTONE
著者Clapperton, J.A., Stucki, M., Mohammad, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J.
登録日2005-09-12
公開日2006-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Cell(Cambridge,Mass.), 123, 2005
2C1J
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MOLECULAR BASIS FOR THE RECOGNITION OF PHOSPHORYLATED AND PHOSPHOACETYLATED HISTONE H3 BY 14-3-3
分子名称:14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I., Macdonald, N., Noble, M.E.M., Nguyen, A., Yaffe, M.B., Clynes, D., Moggs, J.G., Orphanides, G., Thomson, S., Edmunds, J.W., Clayton, A.L., Endicott, J.A., Mahadevan, L.C.
登録日2005-09-15
公開日2005-11-02
最終更新日2013-09-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2C1N
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MOLECULAR BASIS FOR THE RECOGNITION OF PHOSPHORYLATED AND PHOSPHOACETYLATED HISTONE H3 BY 14-3-3
分子名称:14-3-3 PROTEIN ZETA/DELTA, HISTONE H3 ACETYLPHOSPHOPEPTIDE
著者Welburn, J.P.I., Macdonald, N., Noble, M.E.M., Nguyen, A., Yaffe, M.B., Clynes, D., Moggs, J.G., Orphanides, G., Thomson, S., Edmunds, J.W., Clayton, A.L., Endicott, J.A., Mahadevan, L.C.
登録日2005-09-16
公開日2005-11-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular Basis for the Recognition of Phosphorylated and Phosphoacetylated Histone H3 by 14-3-3.
Mol.Cell, 20, 2005
2PIE
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CRYSTAL STRUCTURE OF THE FHA DOMAIN OF RNF8 IN COMPLEX WITH ITS OPTIMAL PHOSPHOPEPTIDE
分子名称:E3 ubiquitin-protein ligase RNF8, phosphopeptide
著者Grant, R.A., Yaffe, M.B.
登録日2007-04-13
公開日2007-12-11
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.
Cell(Cambridge,Mass.), 131, 2007
3C5L
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH PPHSPT PEPTIDE
分子名称:Serine/threonine-protein kinase PLK1, Peptide
著者Lim, D.C., Yaffe, M.B.
登録日2008-01-31
公開日2009-02-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.
Nat.Struct.Mol.Biol., 16, 2009
3FVH
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH AC-LHSPTA-NH2 PEPTIDE
分子名称:Serine/threonine-protein kinase PLK1, Acetyl-Leu-His-Ser-phosphoThr-Ala-NH2 peptide
著者Lim, D.C., Yaffe, M.B.
登録日2009-01-15
公開日2009-08-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Nat.Struct.Mol.Biol., 16, 2009
3RQ7
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POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH A C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR
分子名称:Serine/threonine-protein kinase PLK1, C6H5(CH2)8-derivatized peptide inhibitor
著者Liu, F., Park, J.-E., Qian, W.-J., Lim, D.C., Graber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
登録日2011-04-27
公開日2011-07-20
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel.
Nat.Chem.Biol., 7, 2011
4DFW
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OXIME-BASED POST SOLID-PHASE PEPTIDE DIVERSIFICATION: IDENTIFICATION OF HIGH AFFINITY POLO-LIKE KINASE 1 (PLK1) POLO-BOX DOMAIN BINDING PEPTIDES
分子名称:Serine/threonine-protein kinase PLK1, Peptide, CHLORIDE ION
著者Liu, F., Park, J.-E., Qian, W.-J., Lim, D., Gr ber, M., Berg, T., Yaffe, M.B., Lee, K.S., Burke Jr., T.R.
登録日2012-01-24
公開日2012-03-28
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Oxime-based Post Solid-phase Peptide Diversification: Identification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides
Chem.Biol., 2012
4JIZ
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HUMAN MOB1-PHOSPHOPEPTIDE COMPLEX
分子名称:MOB kinase activator 1A, phosphopeptide, ZINC ION
著者Stach, L., Ogrodowicz, R.W., Rock, J.M., Lim, D., Yaffe, M.B., Amon, A., Smerdon, S.J.
登録日2013-03-07
公開日2013-04-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Science, 340, 2013
4JRN
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ROP18 KINASE DOMAIN IN COMPLEX WITH AMP-PNP AND SUCROSE
分子名称:Rhoptry kinase family protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Lim, D., Gold, D.A., Lindsay, J., Rosowski, E.E., Niedelman, W., Yaffe, M.B., Saeij, J.P.J.
登録日2013-03-21
公開日2013-10-23
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence.
J.Biol.Chem., 288, 2013
4O6W
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PEPTIDE-BASED INHIBITORS OF PLK1 POLO-BOX DOMAIN
分子名称:Serine/threonine-protein kinase PLK1, Peptide-Based inhibitor
著者Qian, W.-J., Park, J.-E., Lim, D.C., Park, S.-Y., Lee, K.-W., Yaffe, M.B., Lee, K.S., Burke, T.R.
登録日2013-12-23
公開日2014-12-03
実験手法X-RAY DIFFRACTION (1.448 Å)
主引用文献Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014
4X9R
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 3B
分子名称:Serine/threonine-protein kinase PLK1, Phosphopeptide macrocycle 3B
著者Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
登録日2014-12-11
公開日2015-07-29
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.398 Å)
主引用文献Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
4X9V
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 3C
分子名称:Serine/threonine-protein kinase PLK1, Phosphopeptide macrocycle 3C
著者Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
登録日2014-12-11
公開日2015-07-29
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (1.429 Å)
主引用文献Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
4X9W
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH BIOACTIVE IMIDAZOLIUM-CONTAINING PHOSPHOPEPTIDE MACROCYCLE 4C
分子名称:Serine/threonine-protein kinase PLK1, Macrocyclic phosphopeptide 4C
著者Grant, R.A., Qian, W.-J., Yaffe, M.B., Burke, T.R.
登録日2014-12-11
公開日2015-07-29
最終更新日2016-01-27
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Neighbor-directed histidine N ( tau )-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.
Biopolymers, 104, 2015
6AX4
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PLK-1 POLO-BOX DOMAIN IN COMPLEX WITH HISTIDINE N(TAU)-CYCLIZED MACROCYCLE 5B.
分子名称:Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b, AMYLAMINE
著者Grant, R.A., Hymel, D., Yaffe, M.B., Burke, T.R.
登録日2017-09-06
公開日2018-09-12
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6QQN
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TUBULIN-TH588 COMPLEX
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Patterson, J.C., Joughin, B.A., Prota, A.E., Muehlethaler, T., Jonas, O.H., Whitman, M.A., Varmeh, S., Chen, S., Balk, S.P., Steinmetz, M.O., Lauffenburger, D.A., Yaffe, M.B.
登録日2019-02-18
公開日2019-07-24
最終更新日2019-08-07
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells.
Cell Syst, 9, 2019
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