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1FMK
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BU of 1fmk by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Descriptor: TYROSINE-PROTEIN KINASE SRC
Authors:Xu, W, Harrison, S.C, Eck, M.J.
Deposit date:1997-01-24
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
7CBO
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BU of 7cbo by Molmil
Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila in complex with GlcNAc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, GLYCEROL, ...
Authors:Xu, W, Wang, M, Zhang, M.
Deposit date:2020-06-13
Release date:2020-08-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and biochemical analyses of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila involved in mucin degradation.
Biochem.Biophys.Res.Commun., 529, 2020
7CBN
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BU of 7cbn by Molmil
Crystal structure of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila
Descriptor: Beta-N-acetylhexosaminidase, GLYCEROL, MALONIC ACID
Authors:Xu, W, Wang, M, Zhang, M.
Deposit date:2020-06-13
Release date:2020-08-12
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and biochemical analyses of beta-N-acetylhexosaminidase Am0868 from Akkermansia muciniphila involved in mucin degradation.
Biochem.Biophys.Res.Commun., 529, 2020
4U2X
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BU of 4u2x by Molmil
Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus
Descriptor: CHLORIDE ION, Importin subunit alpha-6, Membrane-associated protein VP24
Authors:Xu, W, Leung, D, Borek, D, Amarasinghe, G.
Deposit date:2014-07-18
Release date:2014-08-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.153 Å)
Cite:Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Cell Host Microbe, 16, 2014
5VAP
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BU of 5vap by Molmil
Crystal structure of eVP30 C-terminus and eNP peptide
Descriptor: Minor nucleoprotein VP30, NP
Authors:XU, W, WU, C, Leung, D.W, Amarasinghe, G.K.
Deposit date:2017-03-27
Release date:2017-06-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.
Nat Commun, 8, 2017
5VAO
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BU of 5vao by Molmil
Crystal structure of eVP30 C-terminus and eNP peptide
Descriptor: CALCIUM ION, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:XU, W, Leung, D.W, Amarasinghe, G.K.
Deposit date:2017-03-27
Release date:2017-06-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis.
Nat Commun, 8, 2017
1PDN
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BU of 1pdn by Molmil
CRYSTAL STRUCTURE OF A PAIRED DOMAIN-DNA COMPLEX AT 2.5 ANGSTROMS RESOLUTION REVEALS STRUCTURAL BASIS FOR PAX DEVELOPMENTAL MUTATIONS
Descriptor: DNA (5'-D(*AP*AP*CP*GP*TP*CP*AP*CP*GP*GP*TP*TP*GP*AP*C)-3'), DNA (5'-D(*TP*TP*GP*TP*CP*AP*AP*CP*CP*GP*TP*GP*AP*CP*G)-3'), PROTEIN (PRD PAIRED)
Authors:Xu, W, Rould, M.A, Jun, S, Desplan, C, Pabo, C.O.
Deposit date:1995-05-16
Release date:1995-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations.
Cell(Cambridge,Mass.), 80, 1995
5BXO
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BU of 5bxo by Molmil
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
Descriptor: 4,4'-propane-1,3-diylbis(1-methyl-1H-1,2,3-triazole), DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Xu, W, Fischer, G, Hyvonen, M, Itzhaki, L.
Deposit date:2015-06-09
Release date:2016-06-29
Last modified:2023-03-29
Method:X-RAY DIFFRACTION (1.334 Å)
Cite:Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
J.Am.Chem.Soc., 139, 2017
5BXU
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BU of 5bxu by Molmil
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
Descriptor: 4,4'-pentane-1,5-diylbis(1-propyl-1H-1,2,3-triazole), CHLORIDE ION, Tankyrase-2, ...
Authors:Xu, W, Fischer, G, Hyvonen, M, Itzhaki, L.
Deposit date:2015-06-09
Release date:2016-06-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Human Tankyrase-2 in Complex with Extended Stapled Peptide sp4n4m5
to be published
3ELO
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BU of 3elo by Molmil
Crystal Structure of Human Pancreatic Prophospholipase A2
Descriptor: Phospholipase A2, SULFATE ION
Authors:Xu, W, Yi, L, Feng, Y, Chen, L, Liu, J.
Deposit date:2008-09-22
Release date:2009-04-14
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural insight into the activation mechanism of human pancreatic prophospholipase A2
J.Biol.Chem., 284, 2009
2SRC
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BU of 2src by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC, IN COMPLEX WITH AMP-PNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TYROSINE-PROTEIN KINASE SRC
Authors:Xu, W, Doshi, A, Lei, M, Eck, M.J, Harrison, S.C.
Deposit date:1998-12-29
Release date:1999-07-22
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of c-Src reveal features of its autoinhibitory mechanism.
Mol.Cell, 3, 1999
7EHR
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BU of 7ehr by Molmil
Levansucrase from Brenneria sp. EniD 312 at 1.33 angstroms resolution
Descriptor: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Xu, W, Ni, D.W, Hou, X.D, Rao, Y.J, Pijning, T, Guskov, A, Mu, W.M.
Deposit date:2021-03-30
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity.
J.Agric.Food Chem., 70, 2022
7EHS
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BU of 7ehs by Molmil
Levansucrase from Brenneria sp. EniD 312
Descriptor: GLYCEROL, Levansucrase, NONAETHYLENE GLYCOL, ...
Authors:Xu, W, Ni, D.W, Hou, X.D, Rao, Y.J, Pijning, T, Guskov, A, Mu, W.M.
Deposit date:2021-03-30
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity.
J.Agric.Food Chem., 70, 2022
7EHT
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BU of 7eht by Molmil
Levansucrase from Brenneria sp. EniD 312
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GLYCEROL, Levansucrase, ...
Authors:Xu, W, Hou, X.D, Rao, Y.J, Pijning, T, Guskov, A, Mu, W.M.
Deposit date:2021-03-30
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity.
J.Agric.Food Chem., 70, 2022
7FDZ
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BU of 7fdz by Molmil
Levansucrase from Brenneria sp. EniD 312 with sucrose
Descriptor: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Xu, W, Hou, X.D, Rao, Y.J, Pijning, T, Guskov, A, Mu, W.M.
Deposit date:2021-07-19
Release date:2022-04-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity.
J.Agric.Food Chem., 70, 2022
2ZN7
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BU of 2zn7 by Molmil
CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes
Descriptor: 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W, Wu, J.
Deposit date:2008-04-22
Release date:2008-10-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Chemmedchem, 3, 2008
2ZMM
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BU of 2zmm by Molmil
Crystal structure of PTP1B-inhibitor complex
Descriptor: 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(methylcarbamoyl)amino]phenyl}thiophene-2-carboxylic acid, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Xu, W, Wu, J.
Deposit date:2008-04-19
Release date:2008-10-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Chemmedchem, 3, 2008
2ZM3
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BU of 2zm3 by Molmil
Complex Structure of Insulin-like Growth Factor Receptor and Isoquinolinedione Inhibitor
Descriptor: (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione, Insulin-like growth factor 1 receptor
Authors:Xu, W, Mayer, S.C, Boschelli, F, Johnson, M, Dwyer, B.
Deposit date:2008-04-10
Release date:2008-06-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
Bioorg.Med.Chem.Lett., 18, 2008
3PUR
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BU of 3pur by Molmil
CEKDM7A from C.Elegans, complex with D-2-HG
Descriptor: (2R)-2-hydroxypentanedioic acid, FE (II) ION, Lysine-specific demethylase 7 homolog, ...
Authors:Yang, Y, Wang, P, Xu, W, Xu, Y.
Deposit date:2010-12-06
Release date:2011-01-26
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
Cancer Cell, 19, 2011
3PUQ
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BU of 3puq by Molmil
CEKDM7A from C.Elegans, complex with alpha-KG
Descriptor: 2-OXOGLUTARIC ACID, FE (II) ION, GLYCEROL, ...
Authors:Yang, Y, Wang, P, Xu, W, Xu, Y.
Deposit date:2010-12-06
Release date:2011-01-26
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
Cancer Cell, 19, 2011
3F5P
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BU of 3f5p by Molmil
Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
Descriptor: 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile, Insulin-like growth factor 1 receptor
Authors:Xu, W, Miller, L.M, Mayer, S.C, Berger, D.M, Boschelli, D.H, Boschelli, F.
Deposit date:2008-11-04
Release date:2008-12-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
Bioorg.Med.Chem.Lett., 19, 2009
2I47
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BU of 2i47 by Molmil
Crystal structure of catalytic domain of TACE with inhibitor
Descriptor: 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE, ADAM 17, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ...
Authors:Xu, W, Condon, J.S, Lovering, F.E.
Deposit date:2006-08-21
Release date:2006-12-05
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of potent and selective TACE inhibitors via the S1 pocket.
Bioorg.Med.Chem.Lett., 17, 2007
2H4G
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BU of 2h4g by Molmil
Crystal structure of PTP1B with monocyclic thiophene inhibitor
Descriptor: 4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W, Wan, Z.-K.
Deposit date:2006-05-24
Release date:2006-08-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48.
Bioorg.Med.Chem.Lett., 16, 2006
2H4K
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BU of 2h4k by Molmil
Crystal structure of PTP1B with a monocyclic thiophene inhibitor
Descriptor: 4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W, Wan, Z.-K.
Deposit date:2006-05-24
Release date:2006-08-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48.
Bioorg.Med.Chem.Lett., 16, 2006
2HB1
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BU of 2hb1 by Molmil
Crystal Structure of PTP1B with Monocyclic Thiophene Inhibitor
Descriptor: 4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W, Wan, Z.-K, Lee, J.
Deposit date:2006-06-13
Release date:2006-08-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48.
Bioorg.Med.Chem.Lett., 16, 2006

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