Author results

4M4P
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CRYSTAL STRUCTURE OF EPHA4 ECTODOMAIN
Descriptor:Ephrin type-A receptor 4, N-ACETYL-D-GLUCOSAMINE
Authors:Xu, K., Tsvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.-P., Himanen, J.P., Nikolov, D.B.
Deposit date:2013-08-07
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.081 Å)
Cite:Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
4M4R
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EPHA4 ECTODOMAIN COMPLEX WITH EPHRIN A5
Descriptor:Ephrin type-A receptor 4, Ephrin-A5, N-ACETYL-D-GLUCOSAMINE
Authors:Xu, K., Tsvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y.-P., Himanen, J.P., Nikolov, D.B.
Deposit date:2013-08-07
Release date:2013-10-30
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
Proc.Natl.Acad.Sci.USA, 110, 2013
4R0S
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CRYSTAL STRUCTURE OF P. AERUGINOSA TPBA
Descriptor:Protein tyrosine phosphatase TpbA, PHOSPHATE ION, GLYCEROL
Authors:Xu, K., Li, S., Wang, Y., Bartlam, M.
Deposit date:2014-08-01
Release date:2015-05-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1
PLoS ONE, 10, 2015
4R0T
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CRYSTAL STRUCTURE OF P. AERUGINOSA TPBA (C132S) IN COMPLEX WITH PTYR
Descriptor:Protein tyrosine phosphatase TpbA, TYROSINE, PHOSPHATE ION
Authors:Xu, K., Li, S., Wang, Y., Bartlam, M.
Deposit date:2014-08-01
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structural and Biochemical Analysis of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from the Opportunistic Pathogen Pseudomonas aeruginosa PAO1
Plos One, 10
4PLM
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CRYSTAL STRUCTURE OF CHICKEN NETRIN-1 (LN-LE3)
Descriptor:Netrin-1, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2014-05-18
Release date:2014-06-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Science, 344, 2014
4PLN
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CRYSTAL STRUCTURE OF CHICKEN NETRIN-1 (LN-LE3) COMPLEXED WITH MOUSE NEOGENIN (FN4-5)
Descriptor:Netrin-1, Neogenin, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2014-05-18
Release date:2014-06-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Science, 344, 2014
4PLO
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CRYSTAL STRUCTURE OF CHICKEN NETRIN-1 (LN-LE3) IN COMPLEX WITH MOUSE DCC (FN4-5)
Descriptor:Netrin receptor DCC, Netrin-1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2014-05-18
Release date:2014-06-18
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism.
Science, 344, 2014
6CMG
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CRYSTAL STRUCTURE OF THE HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN BOUND TO A POTENT CROSS-REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODY M102.3
Descriptor:Glycoprotein G, m102.3 light chain, IgG Heavy chain, ...
Authors:Xu, K., Nikolov, D.
Deposit date:2018-03-05
Release date:2018-04-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody.
PLoS Pathog., 9, 2013
6CMI
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CRYSTAL STRUCTURE OF THE HENDRA VIRUS ATTACHMENT G GLYCOPROTEIN BOUND TO A POTENT CROSS-REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODY M102.3
Descriptor:Glycoprotein G, m102.3 light chain, IgG Heavy chain, ...
Authors:Xu, K., Nikolov, D.
Deposit date:2018-03-05
Release date:2018-04-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Crystal structure of the Hendra virus attachment G glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody.
PLoS Pathog., 9, 2013
5TKJ
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STRUCTURE OF VACCINE-ELICITED DIVERSE HIV-1 NEUTRALIZING ANTIBODY VFP1.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP1.01 chimeric mouse antibody heavy chain, vFP1.01 chimeric mouse antibody light chain, HIV-1 fusion peptide residue 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2016-10-06
Release date:2018-04-04
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
5TKK
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STRUCTURE OF MOUSE VACCINATION-ELICITED HIV NEUTRALIZING ANTIBODY VFP5.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:HIV-1 fusion peptide residue 512-519, mouse antibody vFP5.01 heavy chain, mouse antibody vFP5.01 light chain
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2016-10-06
Release date:2018-04-04
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDM
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP7.04 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP7.04 heavy chain, vFP7.04 light chain, HIV fusion peptide (512-519)
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDO
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STRUCTURE OF VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP16.02 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP16.02 Fab heavy chain, vFP16.02 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
6CDP
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VACCINE-ELICITED HIV-1 NEUTRALIZING ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 FUSION PEPTIDE RESIDUE 512-519
Descriptor:vFP20.01 Fab heavy chain, vFP20.01 Fab light chain, HIV-1 fusion peptide 512-519, ...
Authors:Xu, K., Liu, K., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
3D11
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CRYSTAL STRUCTURES OF THE NIPAH G ATTACHMENT GLYCOPROTEIN
Descriptor:Hemagglutinin-neuraminidase, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Xu, K., Rajashankar, K.R., Chan, Y.P., Himanen, P., Broder, C.C., Nikolov, D.B.
Deposit date:2008-05-02
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.306 Å)
Cite:Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.
Proc.Natl.Acad.Sci.USA, 105, 2008
3D12
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CRYSTAL STRUCTURES OF NIPAH VIRUS G ATTACHMENT GLYCOPROTEIN IN COMPLEX WITH ITS RECEPTOR EPHRIN-B3
Descriptor:Hemagglutinin-neuraminidase, Ephrin-B3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Rajashankar, K.R., Chan, Y.P., Himanen, P., Broder, C.C., Nikolov, D.B.
Deposit date:2008-05-02
Release date:2008-08-19
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.005 Å)
Cite:Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.
Proc.Natl.Acad.Sci.USA, 105, 2008
4YN0
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CRYSTAL STRUCTURE OF APP E2 DOMAIN IN COMPLEX WITH DR6 CRD DOMAIN
Descriptor:Tumor necrosis factor receptor superfamily member 21, Amyloid beta A4 protein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xu, K., Nikolov, D.
Deposit date:2015-03-08
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.
Genes Dev., 29, 2015
5ECD
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STRUCTURE OF THE SHIGELLA FLEXNERI VAPC MUTANT D98N CRYSTAL FORM 1
Descriptor:tRNA(fMet)-specific endonuclease VapC, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Xu, K.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
5ECW
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STRUCTURE OF THE SHIGELLA FLEXNERI VAPC MUTANT D7A
Descriptor:tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K., Dedic, E., Brodersen, D.E.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
5ECY
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STRUCTURE OF THE SHIGELLA FLEXNERI VAPC MUTANT D98N CRYSTAL FORM 2
Descriptor:tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K., Dedic, E., Brodersen, D.E.
Deposit date:2015-10-20
Release date:2016-10-19
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis on the active site architecture of an activated VapC toxin from Shigella flexneri
to be published
5ED0
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STRUCTURE OF THE SHIGELLA FLEXNERI VAPC MUTANT D7N
Descriptor:tRNA(fMet)-specific endonuclease VapC
Authors:Xu, K., Dedic, E., Brodersen, D.E.
Deposit date:2015-10-20
Release date:2016-02-17
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of the active site architecture of the VapC toxin from Shigella flexneri.
Proteins, 84, 2016
5EVM
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CRYSTAL STRUCTURE OF NIPAH VIRUS FUSION GLYCOPROTEIN IN THE PREFUSION STATE
Descriptor:Fusion glycoprotein F0, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Xu, K., Nikolov, D.B.
Deposit date:2015-11-20
Release date:2015-12-16
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.367 Å)
Cite:Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.
Plos Pathog., 11, 2015
5I8C
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CRYSTAL STRUCTURE OF HIV-1 CLADE A BG505 FUSION PEPTIDE (RESIDUE 512-520) IN COMPLEX WITH BROADLY NEUTRALIZING ANTIBODY VRC34.01 FAB
Descriptor:VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, HIV-1 Clade A BG505 Fusion Peptide (residue 512-520)
Authors:Xu, K., Zhou, T., Liu, K., Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
5I8E
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING HIV-1 FUSION PEPTIDE-TARGETING ANTIBODY VRC34.01 FAB
Descriptor:VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, ZINC ION
Authors:Xu, K., Zhou, T., Liu, K., Kwong, P.D.
Deposit date:2016-02-18
Release date:2016-05-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.655 Å)
Cite:Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
6CDE
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CRYO-EM STRUCTURE AT 3.8 A RESOLUTION OF VACCINE-ELICITED ANTIBODY VFP20.01 IN COMPLEX WITH HIV-1 ENV BG505 DS-SOSIP, AND ANTIBODIES VRC03 AND PGT122
Descriptor:vFP20.01 Heavy Chain, vFP20.01 Light chain, PGT122 Heavy chain, ...
Authors:Acharya, P., Xu, K., Liu, K., Carragher, B., Potter, C.S., Kwong, P.D.
Deposit date:2018-02-08
Release date:2018-05-16
Last modified:2018-06-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018
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