Author results

1KMF
  • Download 1kmf
  • View 1kmf
Molmil generated image of 1kmf
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Xu, B., Hua, Q.X., Nakagawa, S.H., Jia, W., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2001-12-14
Release date:2002-01-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002
1K3M
  • Download 1k3m
  • View 1k3m
Molmil generated image of 1k3m
NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:INSULIN
Authors:Xu, B., Hua, Q.-X., Nakagawa, S.H., Jia, W., Chu, Y.-C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2001-10-03
Release date:2001-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.
Protein Sci., 11, 2002
3OMZ
  • Download 3omz
  • View 3omz
Molmil generated image of 3omz
CRYSTAL STRUCTURE OF MICA-SPECIFIC HUMAN GAMMA DELTA T CELL RECEPTOR
Descriptor:human Vdelta1 gamma delta T cell receptor delta1A/B-3
Authors:Xu, B., Holmes, M.A., Strong, R.K.
Deposit date:2010-08-27
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Crystal structure of a {gamma}{delta} T-cell receptor specific for the human MHC class I homolog MICA.
Proc.Natl.Acad.Sci.USA, 108, 2011
3ROV
  • Download 3rov
  • View 3rov
Molmil generated image of 3rov
INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1Q4V
  • Download 1q4v
  • View 1q4v
Molmil generated image of 1q4v
CRYSTAL STRUCTURE OF ALLO-ILEA2-INSULIN, AN INACTIVE CHIRAL ANALOGUE: IMPLICATIONS FOR THE MECHANISM OF RECEPTOR
Descriptor:Insulin, ZINC ION, PHENOL
Authors:Wan, Z.L., Xu, B., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-08-04
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of allo-Ile(A2)-insulin, an inactive chiral analogue: implications for the mechanism of receptor binding.
Biochemistry, 42, 2003
1RWE
  • Download 1rwe
  • View 1rwe
Molmil generated image of 1rwe
ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
Descriptor:insulin, Insulin, ZINC ION, ...
Authors:Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004
4BV5
  • Download 4bv5
  • View 4bv5
Molmil generated image of 4bv5
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), 4-(aminomethyl)-N-(benzenesulfonyl)cyclohexanecarboxamide
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BV7
  • Download 4bv7
  • View 4bv7
Molmil generated image of 4bv7
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), ACETATE ION, 3-(4-piperidyl)propanoic acid
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVC
  • Download 4bvc
  • View 4bvc
Molmil generated image of 4bvc
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE, ...
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-09
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVD
  • Download 4bvd
  • View 4bvd
Molmil generated image of 4bvd
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 5-chloro-2-fluoro-N-[1-(4-piperidyl)pyrazol-4-yl]benzenesulfonamide
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-25
Release date:2014-07-16
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVV
  • Download 4bvv
  • View 4bvv
Molmil generated image of 4bvv
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, SULFATE ION
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-28
Release date:2014-07-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
4BVW
  • Download 4bvw
  • View 4bvw
Molmil generated image of 4bvw
IDENTIFICATION OF SMALL MOLECULE INHIBITORS SELECTIVE FOR APO(A) KRINGLES KIV-7, KIV-10 AND KV.
Descriptor:APOLIPOPROTEIN(A), CHLORIDE ION, 1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid, ...
Authors:Sandmark, J., Althage, M., Andersson, G.M.K., Antonsson, T., Blaho, S., Bodin, C., Bostrom, J., Chen, Y., Dahlen, A., Eriksson, P.O., Evertsson, E., Fex, T., Fjellstrom, O., Gustafsson, D., Hallberg, C., Hicks, R., Jarkvist, E., Johansson, C., Kalies, I., Kang, D., Svalstedt Karlsson, B., Kartberg, F., Legnehed, A., Lindqvist, A.M., Martinsson, S.A., Moberg, A., Petersson, A.U., Ridderstrom, M., Thelin, A., Tigerstrom, A., Vinblad, J., Xu, B., Knecht, W.
Deposit date:2013-06-28
Release date:2014-07-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
To be Published
5H0R
  • Download 5h0r
  • View 5h0r
Molmil generated image of 5h0r
RNA DEPENDENT RNA POLYMERASE ,VP4,DSRNA
Descriptor:RNA-dependent RNA polymerase, VP4 protein, RNA (42-MER)
Authors:Li, X., Zhou, N., Chen, W., Zhu, B., Wang, X., Xu, B., Wang, J., Liu, H., Cheng, L.
Deposit date:2016-10-06
Release date:2017-01-25
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV
J. Mol. Biol., 429, 2017
5H0S
  • Download 5h0s
  • View 5h0s
Molmil generated image of 5h0s
EM STRUCTURE OF VP1A AND VP1B
Descriptor:VP1
Authors:Li, X., Zhou, N., Xu, B., Chen, W., Zhu, B., Wang, X., Wang, J., Liu, H., Cheng, L.
Deposit date:2016-10-06
Release date:2017-01-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV
J. Mol. Biol., 429, 2017
1T1K
  • Download 1t1k
  • View 1t1k
Molmil generated image of 1t1k
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1P
  • Download 1t1p
  • View 1t1p
Molmil generated image of 1t1p
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1Q
  • Download 1t1q
  • View 1t1q
Molmil generated image of 1t1q
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2012-03-28
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1XW7
  • Download 1xw7
  • View 1xw7
Molmil generated image of 1xw7
DIABETES-ASSOCIATED MUTATIONS IN HUMAN INSULIN: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING STUDIES OF A-CHAIN VARIANT INSULIN WAKAYAMA
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Wan, Z.L., Huang, K., Xu, B., Chu, Y.C., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-10-29
Release date:2005-04-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin wakayama
Biochemistry, 44, 2005
1C6V
  • Download 1c6v
  • View 1c6v
Molmil generated image of 1c6v
SIV INTEGRASE (CATALYTIC DOMAIN + DNA BIDING DOMAIN COMPRISING RESIDUES 50-293) MUTANT WITH PHE 185 REPLACED BY HIS (F185H)
Descriptor:PROTEIN (SIV INTEGRASE), PROTEIN (SIU89134)
Authors:Chen, Z., Yan, Y., Munshi, S., Li, Y., Zruygay-Murphy, J., Xu, B., Witmer, M., Felock, P., Wolfe, A., Sardana, V., Emini, E.A., Hazuda, D., Kuo, L.C.
Deposit date:1999-12-21
Release date:2000-12-27
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform.
J.Mol.Biol., 296, 2000
1Q0B
  • Download 1q0b
  • View 1q0b
Molmil generated image of 1q0b
CRYSTAL STRUCTURE OF THE MOTOR PROTEIN KSP IN COMPLEX WITH ADP AND MONASTROL
Descriptor:Kinesin-like protein KIF11, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Yan, Y., Sardana, V., Xu, B., Halczenko, W., Homnick, C., Buser, C.A., Hartman, G.D., Huber, H.E., Kuo, L.C.
Deposit date:2003-07-15
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of a mitotic motor protein: where, how, and conformational consequences
J.Mol.Biol., 335, 2004
2C0H
  • Download 2c0h
  • View 2c0h
Molmil generated image of 2c0h
X-RAY STRUCTURE OF BETA-MANNANASE FROM BLUE MUSSEL MYTILUS EDULIS
Descriptor:MANNAN ENDO-1,4-BETA-MANNOSIDASE, SULFATE ION
Authors:Larsson, A.M., Anderson, L., Xu, B., Munoz, I.G., Uson, I., Janson, J.-C., Stalbrand, H., Stahlberg, J.
Deposit date:2005-09-02
Release date:2006-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Three-Dimensional Crystal Structure and Enzymic Characterization of Beta-Mannanase Man5A from Blue Mussel Mytilus Edulis.
J.Mol.Biol., 357, 2006
2K91
  • Download 2k91
  • View 2k91
Molmil generated image of 2k91
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K9R
  • Download 2k9r
  • View 2k9r
Molmil generated image of 2k9r
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2LDA
  • Download 2lda
  • View 2lda
Molmil generated image of 2lda
SOLUTION STRUCTURE OF THE ESTROGEN RECEPTOR-BINDING STAPLED PEPTIDE SP2 (AC-HKXLHQXLQDS-NH2)
Descriptor:Estrogen receptor-binding stapled peptide SP2
Authors:Phillips, C., Bazin, R., Bent, A., Davies, N., Moore, R., Pannifer, A., Pickford, A., Prior, S., Read, C., Roberts, L., Schade, M., Scott, A., Brown, D., Xu, B., Irving, S.
Deposit date:2011-05-20
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design and structure of stapled peptides binding to estrogen receptors.
J.Am.Chem.Soc., 133, 2011
2LDC
  • Download 2ldc
  • View 2ldc
Molmil generated image of 2ldc
SOLUTION STRUCTURE OF THE ESTROGEN RECEPTOR-BINDING STAPLED PEPTIDE SP1 (AC-HXILHXLLQDS-NH2)
Descriptor:Estrogen receptor-binding stapled peptide SP1
Authors:Phillips, C., Bazin, R., Bent, A., Davies, N., Moore, R., Pannifer, A., Pickford, A., Prior, S., Read, C., Roberts, L., Schade, M., Scott, A., Brown, D., Xu, B., Irving, S.
Deposit date:2011-05-20
Release date:2011-07-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design and structure of stapled peptides binding to estrogen receptors.
J.Am.Chem.Soc., 133, 2011
<123>