Author results

3CSF
  • Download 3csf
  • View 3csf
Molmil generated image of 3csf
CRYSTAL STRUCTURE OF PI3K P110GAMMA CATALYTICAL DOMAIN IN COMPLEX WITH ORGANORUTHENIUM INHIBITOR DW2
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, RU-PYRIDOCARBAZOLE-2
著者Xie, P., Marmorstein, R.
登録日2008-04-09
公開日2008-05-27
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3CST
  • Download 3cst
  • View 3cst
Molmil generated image of 3cst
CRYSTAL STRUCTURE OF PI3K P110GAMMA CATALYTICAL DOMAIN IN COMPLEX WITH ORGANORUTHENIUM INHIBITOR E5E2
分子名称:Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Methylated Ruthenium Pyridocarbazole
著者Xie, P., Marmorstein, R.
登録日2008-04-10
公開日2008-05-20
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3Q4C
  • Download 3q4c
  • View 3q4c
Molmil generated image of 3q4c
CRYSTAL STRUCTURE OF WILD TYPE BRAF KINASE DOMAIN IN COMPLEX WITH ORGANOMETALLIC INHIBITOR CNS292
分子名称:Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+)
著者Xie, P., Streu, C., Qin, J., Pregman, H., Pagano, N., Meggers, E., Marmorstein, R.
登録日2010-12-23
公開日2011-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry, 48, 2009
1AGN
  • Download 1agn
  • View 1agn
Molmil generated image of 1agn
X-RAY STRUCTURE OF HUMAN SIGMA ALCOHOL DEHYDROGENASE
分子名称:HUMAN SIGMA ALCOHOL DEHYDROGENASE, ZINC ION, ACETATE ION, ...
著者Hurley, T.D., Xie, P.
登録日1996-06-04
公開日1997-03-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity.
J.Biol.Chem., 272, 1997
1ZMS
  • Download 1zms
  • View 1zms
Molmil generated image of 1zms
LMP1 PROTEIN BINDS TO TRAF3 AS A STRUCTURAL CD40
分子名称:TNF receptor associated factor 3, Latent membrane protein 1
著者Wu, S.D., Xie, P., Welsh, K., Li, C., Ni, C.-Z., Zhu, X., Reed, J.C., Satterthwait, A.C., Bishop, G.A., Ely, K.R.
登録日2005-05-10
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3
J.Biol.Chem., 39, 2005
3KVQ
  • Download 3kvq
  • View 3kvq
Molmil generated image of 3kvq
CRYSTAL STRUCTURE OF VEGFR2 EXTRACELLULAR DOMAIN D7
分子名称:Vascular endothelial growth factor receptor 2
著者Yang, Y., Opatowsky, Y., Xie, P., Schlessinger, J.
登録日2009-11-30
公開日2010-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010
4E26
  • Download 4e26
  • View 4e26
Molmil generated image of 4e26
BRAF IN COMPLEX WITH AN ORGANIC INHIBITOR 7898734
分子名称:Serine/threonine-protein kinase B-raf, 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol
著者Qin, J., Xie, P., Ventocilla, C., Zhou, G., Vultur, A., Chen, Q., Herlyn, M., Winkler, J., Marmorstein, R.
登録日2012-03-07
公開日2012-05-09
最終更新日2013-01-09
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
1A4Z
  • Download 1a4z
  • View 1a4z
Molmil generated image of 1a4z
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA COMPLEX WITH NAD (REDUCED) AND SAMARIUM (III)
分子名称:ALDEHYDE DEHYDROGENASE, SAMARIUM (III) ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Steinmetz, C.G., Hurley, T.D.
登録日1998-02-10
公開日1998-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1AG8
  • Download 1ag8
  • View 1ag8
Molmil generated image of 1ag8
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA
分子名称:ALDEHYDE DEHYDROGENASE
著者Steinmetz, C.G., Hurley, T.D.
登録日1997-04-03
公開日1997-10-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.
Structure, 5, 1997
1CW3
  • Download 1cw3
  • View 1cw3
Molmil generated image of 1cw3
HUMAN MITOCHONDRIAL ALDEHYDE DEHYDROGENASE COMPLEXED WITH NAD+ AND MN2+
分子名称:MITOCHONDRIAL ALDEHYDE DEHYDROGENASE, MANGANESE (II) ION, MAGNESIUM ION, ...
著者Ni, L., Zhou, J., Hurley, T.D., Weiner, H.
登録日1999-08-25
公開日1999-08-31
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms.
Protein Sci., 8, 1999