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4FC8
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CRYSTAL STRUCTURE OF TRANSCRIPTION REGULATOR PROTEIN RTR1 FROM KLUYVEROMYCES LACTIS
Descriptor:transcription protein Rtr1, ZINC ION
Authors:Xiang, K., Tong, L.
Deposit date:2012-05-24
Release date:2012-07-25
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity.
Nat Commun, 3, 2012
4H3H
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF HUMAN SYMPLEKIN NTD, HUMAN SSU72 AND A RNA POYMERASE II CTD PEPTIDE PHOSPHORYLATED AT SER-7
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, Pol II CTD peptide, ...
Authors:Xiang, K., Tong, L.
Deposit date:2012-09-13
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Genes Dev., 26, 2012
4H3K
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CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF HUMAN SYMPLEKIN NTD, HUMAN SSU72 AND A RNA POLYMERASE II CTD PEPTIDE PHOSPHORYLATED AT SER-2, SER-5 AND SER-7
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, Hexapeptide, ...
Authors:Xiang, K., Tong, L.
Deposit date:2012-09-13
Release date:2012-10-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72.
Genes Dev., 26, 2012
3O2T
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K., Xiang, S.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2Q
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CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72-CTD PHOSPHOPEPTIDE COMPLEX
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, RNA polymerase II CTD Serine-5 phosphopeptide, ...
Authors:Tong, L., Xiang, K.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3O2S
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CRYSTAL STRUCTURE OF THE HUMAN SYMPLEKIN-SSU72 COMPLEX
Descriptor:Symplekin, RNA polymerase II subunit A C-terminal domain phosphatase SSU72, PHOSPHATE ION
Authors:Tong, L., Xiang, K.
Deposit date:2010-07-22
Release date:2010-10-06
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3ODR
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K.
Deposit date:2010-08-11
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3ODS
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CRYSTAL STRUCTURE OF THE K185A MUTANT OF THE N-TERMINAL DOMAIN OF HUMAN SYMPLEKIN
Descriptor:Symplekin, 1,2-ETHANEDIOL
Authors:Tong, L., Xiang, K.
Deposit date:2010-08-11
Release date:2010-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Nature, 467, 2010
3PIE
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CRYSTAL STRUCTURE OF THE 5'->3' EXORIBONUCLEASE XRN1, E178Q MUTANT
Descriptor:5'->3' EXORIBONUCLEASE (Xrn1)
Authors:Chang, J.H., Xiang, S., Tong, L.
Deposit date:2010-11-06
Release date:2011-02-09
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and biochemical studies of the 5' -> 3' exoribonuclease Xrn1.
Nat.Struct.Mol.Biol., 18, 2011
3PIF
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CRYSTAL STRUCTURE OF THE 5'->3' EXORIBONUCLEASE XRN1, E178Q MUTANT IN COMPLEX WITH MANGANESE
Descriptor:5'->3' EXORIBONUCLEASE (xrn1), MANGANESE (II) ION
Authors:Chang, J.H., Xiang, S., Tong, L.
Deposit date:2010-11-06
Release date:2011-02-09
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Structural and biochemical studies of the 5' -> 3' exoribonuclease Xrn1.
Nat.Struct.Mol.Biol., 18, 2011
6EG2
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CRYSTAL STRUCTURE OF HUMAN BRM IN COMPLEX WITH COMPOUND 16
Descriptor:Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, N-(5-amino-2-chloropyridin-4-yl)-N'-(4-bromo-3-{[3-(hydroxymethyl)phenyl]ethynyl}-1,2-thiazol-5-yl)urea, ISOPROPYL ALCOHOL
Authors:Zhu, X., Kulathila, R., Hu, T., Xie, X.
Deposit date:2018-08-17
Release date:2018-10-31
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
6EG3
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CRYSTAL STRUCTURE OF HUMAN BRM IN COMPLEX WITH COMPOUND 15
Descriptor:Maltose/maltodextrin-binding periplasmic protein,Probable global transcription activator SNF2L2, 3-[(4-{[(2-chloropyridin-4-yl)carbamoyl]amino}pyridin-2-yl)ethynyl]benzoic acid, ETHANOL
Authors:Zhu, X., Kulathila, R., Hu, T., Xie, X.
Deposit date:2018-08-17
Release date:2018-10-31
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
J. Med. Chem., 61, 2018
1WP8
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CRYSTAL STRUCTURE OF HENDRA VIRUS FUSION CORE
Descriptor:Fusion glycoprotein F0,Fusion glycoprotein F0
Authors:Xu, Y., Liu, Y., Lou, Z., Su, N., Bai, Z., Gao, G.F., Rao, Z.
Deposit date:2004-08-31
Release date:2005-11-15
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of Nipah and Hendra virus fusion core proteins
FEBS J., 273, 2006