Author results

4Q91
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CRYSTAL STRUCTURE OF C16A/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Xia, X., Blaber, M.
Deposit date:2014-04-28
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4XKI
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HUMAN FIBROBLAST GROWTH FACTOR - 1 (FGF-1) MUTANT S116R
Descriptor:Fibroblast growth factor 1, SULFATE ION, PHOSPHATE ION, ...
Authors:Xia, X.
Deposit date:2015-01-12
Release date:2016-01-20
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biophysical characterizations of Fibroblast Growth Factor - 1 mutant with increased heparin binding affinity
To Be Published
4YOL
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HUMAN FIBROBLAST GROWTH FACTOR-1 C16S/A66C/C117A/P134A
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Xia, X., Blaber, M.
Deposit date:2015-03-11
Release date:2016-03-16
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
J.Pharm.Sci., 105, 2016
5HZR
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CRYSTAL STRUCTURE OF MTSNF2
Descriptor:SNF2-family ATP dependent chromatin remodeling factor like protein, 3-(1-methylpiperidinium-1-yl)propane-1-sulfonate, SODIUM ION, ...
Authors:Chen, Z.C., Xia, X.
Deposit date:2016-02-02
Release date:2016-07-20
Last modified:2016-08-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of chromatin remodeler Swi2/Snf2 in the resting state
Nat.Struct.Mol.Biol., 23, 2016
4Q9G
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CRYSTAL STRUCTURE OF K12V/C16S/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, FORMIC ACID, PHOSPHATE ION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.554 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4Q9P
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CRYSTAL STRUCTURE OF C16T/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-01
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QAL
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CRYSTAL STRUCTURE OF C117A MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-05
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBC
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM FORMATE BUFFER
Descriptor:Fibroblast growth factor 1, SULFATE ION, FORMIC ACID
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-07
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.519 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QBV
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CRYSTAL STRUCTURE OF C117T MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR IN SODIUM CITRATE BUFFER
Descriptor:Fibroblast growth factor 1, CITRATE ANION
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-08
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.497 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
4QC4
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CRYSTAL STRUCTURE OF C117S MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, SODIUM ION, ...
Authors:Blaber, M., Xia, X.
Deposit date:2014-05-09
Release date:2015-03-11
Method:X-RAY DIFFRACTION (1.491 Å)
Cite:Mutation choice to eliminate buried free cysteines in protein therapeutics.
J.Pharm.Sci., 104, 2015
5X0X
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COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO POSITION +6 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
5X0Y
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COMPLEX OF SNF2-NUCLEOSOME COMPLEX WITH SNF2 BOUND TO SHL2 OF THE NUCLEOSOME
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Liu, X., Xia, X., Chen, Z., Li, X.
Deposit date:2017-01-23
Release date:2017-04-19
Last modified:2017-06-07
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Nature, 544, 2017
5Z3L
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN APO STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3O
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP STATE
Descriptor:Histone H3.2, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3T
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:The structures of Snf2-nucleosome complex in the ADP and ADP-BeFx states
To Be Published
5Z3U
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX AT SHL2 IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-05-22
Method:ELECTRON MICROSCOPY (4.31 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
5Z3V
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STRUCTURE OF SNF2-NUCLEOSOME COMPLEX AT SHL-2 IN ADP BEFX STATE
Descriptor:Transcription regulatory protein SNF2, Histone H3.2, Histone H4, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-01-08
Release date:2019-05-22
Method:ELECTRON MICROSCOPY (4.22 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY2
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
6IY3
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STRUCTURE OF SNF2-MMTV-A NUCLEOSOME COMPLEX AT SHL-2 IN ADP STATE
Descriptor:Histone H3, Histone H4, Histone H2A, ...
Authors:Li, M., Xia, X., Liu, X., Li, X., Chen, Z.
Deposit date:2018-12-12
Release date:2019-04-03
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
Nature, 567, 2019
2XUT
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CRYSTAL STRUCTURE OF A PROTON DEPENDENT OLIGOPEPTIDE (POT) FAMILY TRANSPORTER.
Descriptor:PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S., Drew, D., Cameron, A.D., Postis, V.L., Xia, X., Fowler, P.W., Ingram, J.C., Carpenter, E.P., Sansom, M.S.P., McPherson, M.J., Baldwin, S.A., Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
4F34
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SYMFOIL-4V SYNTHETIC PROTEIN WITH T30E/T72E/T116E MUTATIONS, AND DELTA HIS TAG
Descriptor:de novo protein Symfoil-4V
Authors:Blaber, M., Xia, X.
Deposit date:2012-05-08
Release date:2013-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Symfoil-4V synthetic protein with T30E/T72E/T116E mutations, and delta His tag
TO BE PUBLISHED
4QO3
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CRYSTAL STRUCTURE OF C16S/N18S/K12V/C117V/P134V MUTANT OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
Descriptor:Fibroblast growth factor 1, CITRATE ANION, IMIDAZOLE
Authors:Blaber, M., Xia, X.
Deposit date:2014-06-19
Release date:2015-05-06
Method:X-RAY DIFFRACTION (2.047 Å)
Cite:Thermodynamics of Cysteine Substitution Suggest Unique Structural Role for Cysteine in Proteins
To be Published
5C65
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STRUCTURE OF THE HUMAN GLUCOSE TRANSPORTER GLUT3 / SLC2A3
Descriptor:Solute carrier family 2, facilitated glucose transporter member 3, Octyl Glucose Neopentyl Glycol, ...
Authors:Pike, A.C.W., Quigley, A., Chu, A., Tessitore, A., Xia, X., Mukhopadhyay, S., Wang, D., Kupinska, K., Strain-Damerell, C., Chalk, R., Burgess-Brown, N.A., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
Deposit date:2015-06-22
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the human glucose transporter GLUT3 / SLC2A3
To Be Published
5WLP
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SOLUTION STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF ATG32
Descriptor:Autophagy-related protein 32
Authors:Xue, X., Pellegrini, M., Ragusa, M.J.
Deposit date:2017-07-27
Release date:2018-07-04
Last modified:2019-02-20
Method:SOLUTION NMR
Cite:A pseudo-receiver domain in Atg32 is required for mitophagy.
Autophagy, 14, 2018
2YPT
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CRYSTAL STRUCTURE OF THE HUMAN NUCLEAR MEMBRANE ZINC METALLOPROTEASE ZMPSTE24 MUTANT (E336A) IN COMPLEX WITH A SYNTHETIC CSIM TETRAPEPTIDE FROM THE C-TERMINUS OF PRELAMIN A
Descriptor:CAAX PRENYL PROTEASE 1 HOMOLOG, PRELAMIN-A/C, ZINC ION
Authors:Pike, A.C.W., Dong, Y.Y., Quigley, A., Dong, L., Savitsky, P., Cooper, C.D.O., Chaikuad, A., Goubin, S., Shrestha, L., Li, Q., Mukhopadhyay, S., Yang, J., Xia, X., Shintre, C.A., Barr, A.J., Berridge, G., Chalk, R., Bray, J.E., von Delft, F., Bullock, A., Bountra, C., Arrowsmith, C.H., Edwards, A., Burgess-Brown, N., Carpenter, E.P.
Deposit date:2012-11-01
Release date:2012-12-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:The Structural Basis of Zmpste24-Dependent Laminopathies.
Science, 339, 2013
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