Author results

6J4R
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STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE REGULATOR 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, DNA (5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*TP*AP*TP*AP*TP*GP*G)-3'), ...
Authors:Jiang, M.Q., Sun, L.F., Isupov, M.N.
Deposit date:2019-01-10
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J5B
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STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE REGULATOR 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, DNA (5'-D(*GP*GP*TP*AP*CP*AP*GP*TP*AP*TP*AP*TP*AP*CP*CP*AP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*TP*GP*GP*TP*AP*TP*AP*TP*AP*CP*TP*GP*TP*AP*CP*C)-3')
Authors:Jiang, M.Q., Sun, L.F., Isupov, M.N., Wu, Y.K.
Deposit date:2019-01-10
Release date:2019-04-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J4K
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STRUCTURAL BASIS FOR THE TARGET DNA RECOGNITION AND BINDING BY THE MYB DOMAIN OF PHOSPHATE STARVATION RESPONSE 1
Descriptor:Protein PHOSPHATE STARVATION RESPONSE 1, GLYCEROL, MALONIC ACID
Authors:Jiang, M.Q., Sun, L.F.
Deposit date:2019-01-09
Release date:2019-04-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Structural Basis for the Target DNA Recognition and Binding by the MYB Domain of Phosphate Starvation Response 1.
FEBS J., 2019
6J1L
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CRYTAL STRUCTURE ANALYSIS OF THE ROR GAMMA(C455E)
Descriptor:Nuclear receptor ROR-gamma, 2-[4-(ethylsulfonyl)phenyl]-N-[2'-fluoro-4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)[1,1'-biphenyl]-4-yl]acetamide
Authors:zhang, Y., Li, C.C., wu, X.S.
Deposit date:2018-12-28
Release date:2019-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
J. Med. Chem., 2019
6ND1
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CRYOEM STRUCTURE OF THE SEC COMPLEX FROM YEAST
Descriptor:Protein transport protein SEC61, Protein translocation protein SEC63, Protein transport protein SSS1, ...
Authors:Wu, X., Cabanos, C., Rapoport, T.A.
Deposit date:2018-12-13
Release date:2019-01-09
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structure of the post-translational protein translocation machinery of the ER membrane.
Nature, 566, 2019
6IEG
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CRYSTAL STRUCTURE OF HUMAN MTR4
Descriptor:Exosome RNA helicase MTR4, ADENOSINE-5'-TRIPHOSPHATE
Authors:Chen, J.Y., Yun, C.H.
Deposit date:2018-09-14
Release date:2019-04-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.546 Å)
Cite:NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
6IEH
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CRYSTAL STRUCTURES OF THE HMTR4-NRDE2 COMPLEX
Descriptor:Exosome RNA helicase MTR4, Protein NRDE2 homolog, CHLORIDE ION, ...
Authors:Chen, J.Y., Yun, C.H.
Deposit date:2018-09-14
Release date:2019-04-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.892 Å)
Cite:NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
6E9E
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ESCAS13D-CRRNA BINARY COMPLEX
Descriptor:crRNA (52-MER), EsCas13d, MAGNESIUM ION
Authors:Zhang, C., Lyumkis, D.
Deposit date:2018-08-01
Release date:2018-10-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
6E9F
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ESCAS13D-CRRNA-TARGET RNA TERNARY COMPLEX
Descriptor:EsCas13d, crRNA (52-MER), RNA (27-MER), ...
Authors:Zhang, C., Lyumkis, D.
Deposit date:2018-08-01
Release date:2018-10-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
6CVM
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ATOMIC RESOLUTION CRYO-EM STRUCTURE OF BETA-GALACTOSIDASE
Descriptor:Beta-galactosidase, 2-phenylethyl 1-thio-beta-D-galactopyranoside, MAGNESIUM ION, ...
Authors:Subramaniam, S., Bartesaghi, A., Banerjee, S., Zhu, X., Milne, J.L.S.
Deposit date:2018-03-28
Release date:2018-05-30
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (1.9 Å)
Cite:Atomic Resolution Cryo-EM Structure of beta-Galactosidase.
Structure, 26, 2018
6CMY
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SOLUTION NMR STRUCTURE DETERMINATION OF MOUSE MELANOREGULIN
Descriptor:Melanoregulin
Authors:Rout, A.K., Wu, X., Strub, M.P., Starich, M.R., Hammer III, J.A., Tjandra, N.
Deposit date:2018-03-06
Release date:2018-09-19
Last modified:2018-10-17
Method:SOLUTION NMR
Cite:The Structure of Melanoregulin Reveals a Role for Cholesterol Recognition in the Protein's Ability to Promote Dynein Function.
Structure, 26, 2018
5Z7I
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN(DBD)IN COMPLEX WITH UNMETHYLATED DSDNA
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*AP*TP*TP*CP*GP*C*)-3'), DNA (5'-D(P*GP*CP*GP*AP*AP*TP*CP*AP*GP*G)-3'), ...
Authors:Wu, X., Zhang, Y.
Deposit date:2018-01-29
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5Z0W
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CRYSTAL STRUCTURE OF HIV-1 FUSION INHIBITOR SC29EK COMPLEXED WITH GP41 NHR (N36)
Descriptor:peptide-N, peptide-C
Authors:Liu, Z.X., Qin, B., Cui, S.
Deposit date:2017-12-21
Release date:2018-01-10
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Mechanism of HIV-1 Resistance to an Electronically Constrained alpha-Helical Peptide Membrane Fusion Inhibitor
J. Virol., 92, 2018
5YZV
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BIOPHYSICAL AND STRUCTURAL CHARACTERIZATION OF THE THERMOSTABLE WD40 DOMAIN OF A PROKARYOTIC PROTEIN, THERMOMONOSPORA CURVATA PKWA
Descriptor:Probable serine/threonine-protein kinase PkwA
Authors:Li, D.Y., Shen, C., Du, Y., Qiao, F.F., Kong, T., Yuan, L.R., Zhang, D.L., Wu, X.H., Wu, Y.D.
Deposit date:2017-12-15
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA
Sci Rep, 8, 2018
6BSK
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HUMAN PIM1 KINASE IN COMPLEX WITH COMPOUND 12B
Descriptor:Serine/threonine-protein kinase pim-1, 1,2-ETHANEDIOL, 4-{6-[6-(propan-2-ylamino)-1H-indazol-1-yl]pyrazin-2-yl}benzoic acid, ...
Authors:Ferguson, A.D.
Deposit date:2017-12-03
Release date:2018-03-21
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.573 Å)
Cite:Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Bioorg. Med. Chem. Lett., 28, 2018
5YWF
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CRYSTAL STRUCTURE OF 2H4 FAB
Descriptor:2H4 light chain, 2H4 heavy chain
Authors:Qiu, X., Lei, Y., Yang, P., Gao, Q., Wang, N., Cao, L., Wang, X., Xu, Z.K., Rao, Z.
Deposit date:2017-11-29
Release date:2018-03-21
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
5YWO
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STRUCTURE OF JEV-2F2 FAB COMPLEX
Descriptor:JEV E protein, JEV M protein, 2F2 light chain, ...
Authors:Qiu, X., Lei, Y.F., Yang, P., Gao, Q., Wang, N., Cao, L., Yuan, S., Wang, X., Xu, Z.K., Rao, Z.
Deposit date:2017-11-29
Release date:2018-03-21
Last modified:2018-09-12
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
5YWP
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JEV-2H4 FAB COMPLEX
Descriptor:JEV E protein, JEV M protein, 2H4 light chain, ...
Authors:Qiu, X.D., Lei, Y.F., Yang, P., Gao, Q., WANG, N., Cao, L., Yuan, S., Wang, X.X., Xu, Z.K., Rao, Z.H.
Deposit date:2017-11-29
Release date:2018-05-02
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies
Nat Microbiol, 3, 2018
6BF4
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CRYSTAL STRUCTURE OF HIV-1 CLADE AE STRAIN CNE55 GP120 CORE IN COMPLEX WITH NEUTRALIZING ANTIBODY VRC-PG05 THAT TARGETS THE CENTER OF THE SILENT FACE ON THE OUTER DOMAIN OF GP120
Descriptor:HIV-1 clade AE gp120 core, VRC-PG05 Fab heavy chain, VRC-PG05 Fab light chain, ...
Authors:Zhou, T., Kwong, P.D.
Deposit date:2017-10-25
Release date:2018-03-07
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.382 Å)
Cite:A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.
Immunity, 48, 2018
5YIU
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN (DBD)
Descriptor:Cell cycle regulatory protein GcrA
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIV
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN(DBD) IN COMPLEX WITH METHYLATED DSDNA(CRYSTAL FORM 1)
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*TP*GP*(6MA)P*TP*TP*CP*G)-3'), DNA (5'-D(*CP*CP*GP*(6MA)P*AP*TP*CP*AP*G)-3')
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.914 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIW
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CAULOBACTER CRESCENTUS GCRA DNA-BINDING DOMAIN (DBD) IN COMPLEX WITH METHYLATED DSDNA (CRYSTAL FORM 2)
Descriptor:Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*(6MA)P*TP*TP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*(6MA)P*AP*TP*CP*AP*GP*G)-3'), ...
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
5YIX
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CAULOBACTER CRESCENTUS GCRA SIGMA-INTERACTING DOMAIN (SID) IN COMPLEX WITH DOMAIN 2 OF SIGMA 70
Descriptor:RNA polymerase sigma factor RpoD, Cell cycle regulatory protein GcrA, (R,R)-2,3-BUTANEDIOL, ...
Authors:Wu, X., Zhang, Y.
Deposit date:2017-10-06
Release date:2018-03-21
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA.
Nucleic Acids Res., 46, 2018
6B7M
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CRYSTAL STRUCTURE OF LEGIONELLA EFFECTOR SDED (LPG2509) IN COMPLEX WITH UBIQUITIN
Descriptor:SdeD (lpg2509), Polyubiquitin-C
Authors:Mao, Y., Akturk, A., Wasilko, J.
Deposit date:2017-10-04
Release date:2018-04-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.
Nature, 557, 2018
6B7O
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CRYSTAL STRUCTURE OF LEGIONELLA EFFECTOR SDED (LPG2509) H67A IN COMPLEX WITH ADP-RIBOSYLATED UBIQUITIN
Descriptor:SdeD (lpg2509) H67A, Polyubiquitin-C, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Mao, Y., Akturk, A., Wasilko, J.
Deposit date:2017-10-04
Release date:2018-04-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.
Nature, 557, 2018