Author results

5V9U
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CRYSTAL STRUCTURE OF SMALL MOLECULE ARS-1620 COVALENTLY BOUND TO K-RAS G12C
Descriptor:GTPase KRas, CALCIUM ION, (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, ...
Authors:Janes, M.R., Zhang, J., Li, L.-S., Hansen, R., Peters, U., Guo, X., Chen, Y., Babbar, A., Firdaus, S.J., Feng, J., Chen, J.H., Li, S., Brehmer, D., Darjania, L., Li, S., Long, Y.O., Thach, C., Liu, Y., Zarieh, A., Ely, T., Kucharski, J.M., Kessler, L.V., Wu, T., Wang, Y., Yao, Y., Deng, X., Zarrinkar, P., Dashyant, D., Lorenzi, M.V., Hu-Lowe, D., Patricelli, M.P., Ren, P., Liu, Y.
Deposit date:2017-03-23
Release date:2018-02-07
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
1P2F
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CRYSTAL STRUCTURE ANALYSIS OF RESPONSE REGULATOR DRRB, A THERMOTOGA MARITIMA OMPR/PHOB HOMOLOG
Descriptor:Response Regulator
Authors:Robinson, V.L., Wu, T., Stock, A.M.
Deposit date:2003-04-15
Release date:2003-04-29
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the domain interface in DrrB, a response regulator of the OmpR/PhoB subfamily
J.Bacteriol., 185, 2003
1ZGZ
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CRYSTAL STRUCTURE OF THE RECEIVER DOMAIN OF TMAO RESPIRATORY SYSTEM RESPONSE REGULATOR TORR
Descriptor:TorCAD operon transcriptional regulatory protein torR, SULFATE ION, GLYCEROL
Authors:Toro-Roman, A., Wu, T., Stock, A.M.
Deposit date:2005-04-22
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A common dimerization interface in bacterial response regulators KdpE and TorR.
Protein Sci., 14, 2005
1ZH2
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CRYSTAL STRUCTURE OF THE CALCIUM-BOUND RECEIVER DOMAIN OF KDP POTASSIUM TRANSPORT SYSTEM RESPONSE REGULATOR KDPE
Descriptor:KDP operon transcriptional regulatory protein kdpE, CALCIUM ION
Authors:Toro-Roman, A., Wu, T., Stock, A.M.
Deposit date:2005-04-22
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common dimerization interface in bacterial response regulators KdpE and TorR.
Protein Sci., 14, 2005
1ZH4
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CRYSTAL STRUCTURE OF THE MG+2/BEF3-BOUND RECEIVER DOMAIN OF KDP POTASSIUM TRANSPORT SYSTEM RESPONSE REGULATOR KDPE
Descriptor:KDP operon transcriptional regulatory protein kdpE, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION
Authors:Toro-Roman, A., Wu, T., Stock, A.M.
Deposit date:2005-04-22
Release date:2005-12-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A common dimerization interface in bacterial response regulators KdpE and TorR.
Protein Sci., 14, 2005
2FOJ
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH P53 PEPTIDE 364-367
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOO
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH P53 PEPTIDE 359-362
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, p53 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
2FOP
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THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 COMPLEXED WITH MDM2 PEPTIDE 147-150
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, mdm2 peptide
Authors:Saridakis, V., Sheng, Y., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H., Frappier, L.
Deposit date:2006-01-13
Release date:2006-02-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat.Struct.Mol.Biol., 13, 2006
3BS1
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STRUCTURE OF THE STAPHYLOCOCCUS AUREUS AGRA LYTTR DOMAIN BOUND TO DNA REVEALS A BETA FOLD WITH A NOVEL MODE OF BINDING
Descriptor:DNA (5'-D(*DTP*DTP*DTP*DAP*DAP*DCP*DAP*DGP*DTP*DTP*DAP*DAP*DGP*(BRU)P*DAP*DT)-3'), DNA (5'-D(*DAP*DAP*(BRU)P*DAP*DCP*DTP*DTP*DAP*DAP*DCP*DTP*DGP*DTP*DTP*DAP*DA)-3'), Accessory gene regulator protein A, ...
Authors:Sidote, D.J., Barbieri, C., Wu, T., Stock, A.M.
Deposit date:2007-12-21
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the Staphylococcus aureus AgrA LytTR Domain Bound to DNA Reveals a Beta Fold with an Unusual Mode of Binding.
Structure, 16, 2008
4D2P
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
Descriptor:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium
Authors:Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
Deposit date:2014-05-12
Release date:2014-10-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2T
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
Descriptor:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3-[2-(phenylcarbamoyl)-5-(1H-pyrazol-4-yl)phenoxy]propan-1-aminium
Authors:Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
Deposit date:2014-05-13
Release date:2014-10-15
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2V
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
Descriptor:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium
Authors:Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
Deposit date:2014-05-13
Release date:2014-10-15
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2W
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
Descriptor:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 4-bromo-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
Authors:Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
Deposit date:2014-05-13
Release date:2014-10-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4GXP
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CHIMERIC FAMILY 1 BETA-GLUCOSIDASE MADE WITH NON-CONTIGUOUS SCHEMA
Descriptor:Beta-glucosidase Chimeric protein
Authors:Smith, M.A., Romero, P.A., Wu, T., Brustad, E.M., Arnold, F.H.
Deposit date:2012-09-04
Release date:2013-01-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Chimeragenesis of distantly-related proteins by noncontiguous recombination.
Protein Sci., 22, 2013
4H86
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CRYSTAL STRUCTURE OF AHP1 FROM SACCHAROMYCES CEREVISIAE IN REDUCED FORM
Descriptor:Peroxiredoxin type-2
Authors:Liu, M., Wang, F., Qiu, R., Wu, T., Gu, S., Tang, R., Ji, C.
Deposit date:2012-09-21
Release date:2012-10-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Crystal structure of Ahp1 from Saccharomyces cerevisiae in reduced form
To be Published
4JK7
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OPEN AND CLOSED FORMS OF WILD-TYPE HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, GLYCEROL, CHLORIDE ION, ...
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JK8
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OPEN AND CLOSED FORMS OF R1865A HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, GLYCEROL, CHLORIDE ION, ...
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JK9
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OPEN AND CLOSED FORMS OF WILD-TYPE HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND CO ION
Descriptor:Pre-mRNA-processing-splicing factor 8, COBALT (II) ION, GLYCEROL, ...
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKA
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OPEN AND CLOSED FORMS OF R1865A HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND CO ION
Descriptor:Pre-mRNA-processing-splicing factor 8, COBALT (II) ION, CHLORIDE ION
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKB
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OPEN AND CLOSED FORMS OF V1788D HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, GLYCEROL, CHLORIDE ION, ...
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKC
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OPEN AND CLOSED FORMS OF T1800E HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, CHLORIDE ION, GLYCEROL, ...
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKD
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OPEN AND CLOSED FORMS OF I1790Y HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, MAGNESIUM ION, CHLORIDE ION
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKE
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OPEN AND CLOSED FORMS OF T1789P HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, MAGNESIUM ION
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKF
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OPEN AND CLOSED FORMS OF T1791P+R1865A HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, MAGNESIUM ION
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
4JKG
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OPEN AND CLOSED FORMS OF MIXED T1789P+R1865A AND R1865A HUMAN PRP8 RNASE H-LIKE DOMAIN WITH BOUND MG ION
Descriptor:Pre-mRNA-processing-splicing factor 8, MAGNESIUM ION
Authors:Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.
Deposit date:2013-03-09
Release date:2013-05-22
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.
Nat.Struct.Mol.Biol., 20, 2013
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