Author results

2KXJ
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SOLUTION STRUCTURE OF UBX DOMAIN OF HUMAN UBXD2 PROTEIN
Descriptor:UBX domain-containing protein 4
Authors:Wu, Q., Huang, H., Zhang, J., Hu, Q., Wu, J., Shi, Y.
Deposit date:2010-05-06
Release date:2011-05-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution strcture of UBX domain of human UBXD2 protein
To be Published
1YZ3
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STRUCTURE OF HUMAN PNMT COMPLEXED WITH COFACTOR PRODUCT ADOHCY AND INHIBITOR SK&F 64139
Descriptor:Phenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Wu, Q., Gee, C.L., Lin, F., Martin, J.L., Grunewald, G.L., McLeish, M.J.
Deposit date:2005-02-27
Release date:2006-02-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J.Med.Chem., 48, 2005
2KB2
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BLRP1 BLUF
Descriptor:BlrP1, FLAVIN MONONUCLEOTIDE
Authors:Wu, Q., Gardner, K.H.
Deposit date:2008-11-19
Release date:2009-04-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and insight into blue light-induced changes in the BlrP1 BLUF domain
Biochemistry, 48, 2009
3W03
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XLF-XRCC4 COMPLEX
Descriptor:Non-homologous end-joining factor 1, DNA repair protein XRCC4
Authors:Wu, Q., Ochi, T., Matak-Vinkovic, D., Robinson, C.V., Chirgadze, D.Y., Blundell, T.L.
Deposit date:2012-10-17
Release date:2012-11-07
Method:X-RAY DIFFRACTION (8.492 Å)
Cite:Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions
Biochem.Soc.Trans., 39, 2011
4LX3
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CONSERVED RESIDUES THAT MODULATE PROTEIN TRANS-SPLICING OF NPU DNAE SPLIT INTEIN
Descriptor:DNA polymerase III, alpha subunit, Nucleic acid binding, ...
Authors:Wu, Q., Gao, Z., Wei, Y., Ma, G., Zheng, Y., Dong, Y., Liu, Y.
Deposit date:2013-07-29
Release date:2014-06-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Conserved Residues that Modulate Protein trans-Splicing of Npu DnaE Split Intein
Biochem.J., 2014
4Y18
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STRUCTURE OF BRCA1 BRCT DOMAINS IN COMPLEX WITH ABRAXAS DOUBLE PHOSPHORYLATED PEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas
Authors:Wu, Q., Blundell, T.L.
Deposit date:2015-02-06
Release date:2016-01-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
4Y2G
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STRUCTURE OF BRCA1 BRCT DOMAINS IN COMPLEX WITH ABRAXAS SINGLE PHOSPHORYLATED PEPTIDE
Descriptor:Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas
Authors:Wu, Q., Blundell, T.L.
Deposit date:2015-02-09
Release date:2016-01-27
Last modified:2016-02-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
4I8B
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CRYSTAL STRUCTURE OF THIOREDOXIN FROM SCHISTOSOMA JAPONICUM
Descriptor:Thioredoxin
Authors:Wu, Q., Peng, Y., Zhao, J., Li, X., Fan, X., Zhou, X., Chen, J., Luo, Z., Shi, D.
Deposit date:2012-12-03
Release date:2013-12-04
Last modified:2015-06-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum.
Parasitology, 142, 2015
4KZI
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CRYSTAL STRUCTURE OF TR3 LBD IN COMPLEX WITH DPDO
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, 1-(3,5-dimethoxyphenyl)decan-1-one
Authors:Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
Nat.Struct.Mol.Biol., 2013
4KZJ
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CRYSTAL STRUCTURE OF TR3 LBD L449W MUTANT
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
Nat.Struct.Mol.Biol., 2013
4KZM
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CRYSTAL STRUCTURE OF TR3 LBD S553A MUTANT
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Li, F., Zhang, Q., Li, A., Tian, X., Cai, Q., Wang, W., Wang, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.
Deposit date:2013-05-30
Release date:2013-12-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling
Nat.Struct.Mol.Biol., 2013
4JGV
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CRYSTAL STRUCTURE OF HUMAN NUR77 LIGAND-BINDING DOMAIN IN COMPLEX WITH THPN
Descriptor:Nuclear receptor subfamily 4 group A member 1, 1-(3,4,5-trihydroxyphenyl)nonan-1-one, GLYCEROL
Authors:Zhang, Q., Li, F., Li, A., Tian, X., Wan, W., Wan, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.
Deposit date:2013-03-04
Release date:2013-12-18
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Nat.Chem.Biol., 10, 2014
3V3E
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CRYSTAL STRUCTURE OF THE HUMAN NUR77 LIGAND-BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-13
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
3V3Q
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CRYSTAL STRUCTURE OF HUMAN NUR77 LIGAND-BINDING DOMAIN IN COMPLEX WITH ETHYL 2-[2,3,4 TRIMETHOXY-6(1-OCTANOYL)PHENYL]ACETATE
Descriptor:Nuclear receptor subfamily 4 group A member 1, ethyl (2,3,4-trimethoxy-6-octanoylphenyl)acetate, GLYCEROL, ...
Authors:Zhang, Q., Shi, C., Yang, K., Chen, Y., Zhan, Y., Wu, Q., Lin, T.
Deposit date:2011-12-14
Release date:2012-09-26
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Nat.Chem.Biol., 8, 2012
4RZF
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CRYSTAL STRUCTURE ANALYSIS OF THE NUR77 LIGAND BINDING DOMAIN, S441W MUTANT
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL
Authors:Li, F., Tian, X., Li, A., Li, L., Liu, Y., Chen, H., Wu, Q., Lin, T.
Deposit date:2014-12-21
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Nat.Chem.Biol., 11, 2015
4RZG
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CRYSTAL STRUCTURE ANALYSIS OF THE DNPA-BOUNDED NUR77 LIGAND BINDING DOMAIN
Descriptor:Nuclear receptor subfamily 4 group A member 1, GLYCEROL, pentyl (3,5-dihydroxy-2-nonanoylphenyl)acetate
Authors:Li, F., Tian, X., Li, A., Li, L., Liu, Y., Chen, H., Wu, Q., Lin, T.
Deposit date:2014-12-21
Release date:2015-03-18
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Nat.Chem.Biol., 11, 2015
1K86
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CRYSTAL STRUCTURE OF CASPASE-7
Descriptor:caspase-7
Authors:Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y.
Deposit date:2001-10-23
Release date:2001-11-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
1K88
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CRYSTAL STRUCTURE OF PROCASPASE-7
Descriptor:procaspase-7
Authors:Chai, J., Wu, Q., Shiozaki, E., Srinivasa, S.M., Alnemri, E.S., Shi, Y.
Deposit date:2001-10-23
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding
Cell(Cambridge,Mass.), 107, 2001
2AN3
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STRUCTURE OF PNMT WITH S-ADENOSYL-L-HOMOCYSTEINE AND THE SEMI-RIGID ANALOGUE ACCEPTOR SUBSTRATE CIS-(1R,2S)-2-AMINO-1-TETRALOL.
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN4
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STRUCTURE OF PNMT COMPLEXED WITH S-ADENOSYL-L-HOMOCYSTEINE AND THE ACCEPTOR SUBSTRATE OCTOPAMINE
Descriptor:Phenylethanolamine N-methyltransferase, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2AN5
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STRUCTURE OF HUMAN PNMT COMPLEXED WITH S-ADENOSYL-HOMOCYSTEINE AND AN INHIBITOR, TRANS-(1S,2S)-2-AMINO-1-TETRALOL
Descriptor:Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, ...
Authors:Gee, C.L., Tyndall, J.D.A., Grunewald, G.L., Wu, Q., McLeish, M.J., Martin, J.L.
Deposit date:2005-08-11
Release date:2006-03-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis
Biochemistry, 44, 2005
2BYC
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BLRB - A BLUF PROTEIN, DARK STATE STRUCTURE
Descriptor:BLUE-LIGHT RECEPTOR OF THE BLUF-FAMILY, FLAVIN MONONUCLEOTIDE
Authors:Jung, A., Domratcheva, T., Tarutina, M., Wu, Q., Ko, W.H., Shoeman, R.L., Gomelsky, M., Gardner, K.H., Schlichting, I.
Deposit date:2005-07-29
Release date:2005-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Bacterial Bluf Photoreceptor: Insights Into Blue Light-Mediated Signal Transduction.
Proc.Natl.Acad.Sci.USA, 102, 2005
2F9S
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2ND CRYSTAL STRUCTURE OF A SOLUBLE DOMAIN OF RESA IN THE OXIDISED FORM
Descriptor:Thiol-disulfide oxidoreductase resA
Authors:Colbert, C.L., Wu, Q., Erbel, P.J.A., Gardner, K.H., Deisenhofer, J.
Deposit date:2005-12-06
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation
Proc.Natl.Acad.Sci.USA, 103, 2006
2MNC
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OLIGONUCLEOTIDE MODEL OF MIR-21 PRE-ELEMENT
Descriptor:RNA (5'-R(*GP*GP*GP*UP*UP*GP*AP*CP*CP*GP*UP*UP*GP*AP*AP*UP*CP*UP*CP*AP*CP*GP*GP*CP*AP*AP*CP*CP*C)-3')
Authors:Chirayil, S., Wu, Q., Amezcua, C., Luebke, K.
Deposit date:2014-04-02
Release date:2014-10-01
Last modified:2014-10-08
Method:SOLUTION NMR
Cite:NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element.
Plos One, 9, 2014
3P4K
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THE THIRD CONFORMATION OF P38A MAP KINASE OBSERVED IN PHOSPHORYLATED P38A AND IN SOLUTION
Descriptor:Mitogen-activated protein kinase 14, MAP kinase 14
Authors:Akella, R., Min, X., Wu, Q., Gardner, K.H., Goldsmith, E.J.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:The third conformation of p38a MAP kinase observed in phosphorylated p38a and in solution
Structure, 18, 2010