Author results

1A43
  • Download 1a43
  • View 1a43
Molmil generated image of 1a43
STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION
Descriptor:HIV-1 CAPSID
Authors:Worthylake, D.K., Wang, H., Yoo, S., Sundquist, W.I., Hill, C.P.
Deposit date:1998-02-10
Release date:1999-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1AYZ
  • Download 1ayz
  • View 1ayz
Molmil generated image of 1ayz
CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE UBIQUITIN-CONJUGATING ENZYME RAD6 (UBC2) AT 2.6A RESOLUTION
Descriptor:UBIQUITIN-CONJUGATING ENZYME RAD6
Authors:Worthylake, D.K., Prakash, S., Prakash, L., Hill, C.P.
Deposit date:1997-11-12
Release date:1998-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution.
J.Biol.Chem., 273, 1998
1BAJ
  • Download 1baj
  • View 1baj
Molmil generated image of 1baj
HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN
Descriptor:GAG POLYPROTEIN
Authors:Worthylake, D.K., Wang, H., Yoo, S., Sundquist, W.I., Hill, C.P.
Deposit date:1998-04-17
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
1FOE
  • Download 1foe
  • View 1foe
Molmil generated image of 1foe
CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Descriptor:T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE, SULFATE ION
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2000-08-27
Release date:2001-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.
Nature, 408, 2000
1RJ2
  • Download 1rj2
  • View 1rj2
Molmil generated image of 1rj2
CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF DBS WITHOUT BOUND GTPASE
Descriptor:Guanine nucleotide exchange factor DBS [Fragment]
Authors:Worthylake, D.K., Rossman, K.L., Sondek, J.
Deposit date:2003-11-18
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Structure, 12, 2004
5CJP
  • Download 5cjp
  • View 5cjp
Molmil generated image of 5cjp
THE STRUCTURAL BASIS FOR CDC42-INDUCED DIMERIZATION OF IQGAPS
Descriptor:Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a, ...
Authors:Worthylake, D.K., Boyapati, V.K., LeCour Jr, L.
Deposit date:2015-07-14
Release date:2016-08-10
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.
Structure, 24, 2016
1A8O
  • Download 1a8o
  • View 1a8o
Molmil generated image of 1a8o
HIV CAPSID C-TERMINAL DOMAIN
Descriptor:HIV CAPSID
Authors:Gamble, T.R., Yoo, S., Vajdos, F.F., Von Schwedler, U.K., Worthylake, D.K., Wang, H., Mccutcheon, J.P., Sundquist, W.I., Hill, C.P.
Deposit date:1998-03-27
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
Science, 278, 1997
1AK4
  • Download 1ak4
  • View 1ak4
Molmil generated image of 1ak4
HUMAN CYCLOPHILIN A BOUND TO THE AMINO-TERMINAL DOMAIN OF HIV-1 CAPSID
Descriptor:CYCLOPHILIN A, HIV-1 CAPSID
Authors:Hill, C.P., Gamble, T.R., Vajdos, F.F., Worthylake, D.K., Sundquist, W.I.
Deposit date:1997-05-28
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.
Cell(Cambridge,Mass.), 87, 1996
1AUM
  • Download 1aum
  • View 1aum
Molmil generated image of 1aum
HIV CAPSID C-TERMINAL DOMAIN (CAC146)
Descriptor:HIV CAPSID
Authors:Hill, C.P., Gamble, T.R., Yoo, S., Vajdos, F.F., Von Schwedler, U.K., Worthylake, D.K., Wang, H., Mccutcheon, J.P., Sundquist, W.I.
Deposit date:1997-08-29
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.
Science, 278, 1997
1KZ7
  • Download 1kz7
  • View 1kz7
Molmil generated image of 1kz7
CRYSTAL STRUCTURE OF THE DH/PH FRAGMENT OF MURINE DBS IN COMPLEX WITH THE PLACENTAL ISOFORM OF HUMAN CDC42
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1KZG
  • Download 1kzg
  • View 1kzg
Molmil generated image of 1kzg
DBSCDC42(Y889F)
Descriptor:GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS, CDC42 HOMOLOG
Authors:Rossman, K.L., Worthylake, D.K., Snyder, J.T., Siderovski, D.P., Campbell, S.L., Sondek, J.
Deposit date:2002-02-06
Release date:2002-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
EMBO J., 21, 2002
1LB1
  • Download 1lb1
  • View 1lb1
Molmil generated image of 1lb1
CRYSTAL STRUCTURE OF THE DBL AND PLECKSTRIN HOMOLOGY DOMAINS OF DBS IN COMPLEX WITH RHOA
Descriptor:Guanine nucleotide exchange factor DBS, Transforming protein RhoA
Authors:Snyder, J.T., Worthylake, D.K., Rossman, K.L., Betts, L., Pruitt, W.M., Siderovski, D.P., Der, C.J., Sondek, J.
Deposit date:2002-04-01
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
2NZ8
  • Download 2nz8
  • View 2nz8
Molmil generated image of 2nz8
N-TERMINAL DHPH CASSETTE OF TRIO IN COMPLEX WITH NUCLEOTIDE-FREE RAC1
Descriptor:ras-related C3 botulinum toxin substrate 1 isoform Rac1, triple functional domain protein
Authors:Chhatriwala, M.K., Betts, L., Worthylake, D.K., Sondek, J.
Deposit date:2006-11-22
Release date:2007-04-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
J.Mol.Biol., 368, 2007
3FAY
  • Download 3fay
  • View 3fay
Molmil generated image of 3fay
CRYSTAL STRUCTURE OF THE GAP-RELATED DOMAIN OF IQGAP1
Descriptor:Ras GTPase-activating-like protein IQGAP1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Kurella, V.B., Richard, J.M., Parke, C.L., Bellamy, H., Worthylake, D.K.
Deposit date:2008-11-18
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the GTPase-activating protein-related domain from IQGAP1.
J.Biol.Chem., 284, 2009
3HQD
  • Download 3hqd
  • View 3hqd
Molmil generated image of 3hqd
HUMAN KINESIN EG5 MOTOR DOMAIN IN COMPLEX WITH AMPPNP AND MG2+
Descriptor:Kinesin-like protein KIF11, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PHOSPHATE ION, ...
Authors:Parke, C.L., Wojcik, E.J., Kim, S., Worthylake, D.K.
Deposit date:2009-06-05
Release date:2009-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism.
J.Biol.Chem., 285, 2010
3KEN
  • Download 3ken
  • View 3ken
Molmil generated image of 3ken
HUMAN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, S-TRITYL-L-CYSTEINE, ...
Authors:Parke, C.L., Wojcik, E.J., Kim, S., Worthylake, D.K.
Deposit date:2009-10-26
Release date:2010-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
J.Biol.Chem., 285, 2010
4H20
  • Download 4h20
  • View 4h20
Molmil generated image of 4h20
CRYSTAL STRUCTURE AND COMPUTATIONAL MODELING OF THE FAB FRAGMENT FROM THE PROTECTIVE ANTI-RICIN MONOCLONAL ANTIBODY RAC18
Descriptor:Light chain of Fab Fragment from the anti-Ricin Monoclonal Antibody RAC18, Heavy chain of Fab Fragment from the anti-Ricin Monoclonal Antibody RAC18
Authors:Zhao, Z., Worthylake, D.K., LeCour Jr., L.F., Maresh, G., Pincus, S.H.
Deposit date:2012-09-11
Release date:2012-10-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and computational modeling of the fab fragment from a protective anti-ricin monoclonal antibody.
Plos One, 7, 2012
5L0O
  • Download 5l0o
  • View 5l0o
Molmil generated image of 5l0o
IQGAP1 CALPONIN HOMOLOGY DOMAIN FRAGMENT (CHDF) MUTANT K161C UNDER OXIDIZING CONDITIONS
Descriptor:Ras GTPase-activating-like protein IQGAP1
Authors:Liu, J., Worthylake, D.
Deposit date:2016-07-27
Release date:2016-09-28
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:The IQGAP1 N-Terminus Forms Dimers, and the Dimer Interface Is Required for Binding F-Actin and Calcium-Bound Calmodulin.
Biochemistry, 55, 2016
1KI1
  • Download 1ki1
  • View 1ki1
Molmil generated image of 1ki1
GUANINE NUCLEOTIDE EXCHANGE REGION OF INTERSECTIN IN COMPLEX WITH CDC42
Descriptor:G25K GTP-binding protein, placental isoform, intersectin long form, ...
Authors:Snyder, J.T., Pruitt, W.M., Der, C.J., Sondek, J.
Deposit date:2001-12-02
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nat.Struct.Biol., 9, 2002
2FJU
  • Download 2fju
  • View 2fju
Molmil generated image of 2fju
ACTIVATED RAC1 BOUND TO ITS EFFECTOR PHOSPHOLIPASE C BETA 2
Descriptor:Ras-related C3 botulinum toxin substrate 1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2, MAGNESIUM ION, ...
Authors:Jezyk, M.R., Snyder, J.T., Harden, T.K., Sondek, J.
Deposit date:2006-01-03
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Rac1 bound to its effector phospholipase C-beta2.
Nat.Struct.Mol.Biol., 13, 2006
3I6X
  • Download 3i6x
  • View 3i6x
Molmil generated image of 3i6x
CRYSTAL STRUCTURE OF THE CALPONIN HOMOLOGY DOMAIN OF IQGAP1
Descriptor:Ras GTPase-activating-like protein IQGAP1
Authors:Kurella, V.B.
Deposit date:2009-07-07
Release date:2010-07-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The IQGAP1 N-terminus Forms Dimers and the Dimer Interface is Required for Binding F-actin and Ca2+/calmodulin.
Biochemistry, 2016
2ZKM
  • Download 2zkm
  • View 2zkm
Molmil generated image of 2zkm
CRYSTAL STRUCTURE OF PHOSPHOLIPASE C BETA 2
Descriptor:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2, CALCIUM ION
Authors:Hicks, S.N., Jezyk, M.R., Gershberg, S., Seifert, J.P., Harden, T.K., Sondek, J.
Deposit date:2008-03-26
Release date:2008-08-12
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:General and versatile autoinhibition of PLC isozymes
Mol.Cell, 31, 2008