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2BF9
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BU of 2bf9 by Molmil
Anisotropic refinement of avian (turkey) pancreatic polypeptide at 0. 99 Angstroms resolution.
Descriptor: PANCREATIC HORMONE, ZINC ION
Authors:Tickle, I, Glover, I, Pitts, J, Wood, S, Blundell, T.L.
Deposit date:2004-12-06
Release date:2004-12-08
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Conformational Flexibility in a Small Globular Hormone. X-Ray Analysis of Avian Pancreatic Polypeptide at 0.98 Angstroms Resolution
Biopolymers, 22, 1983
2BJI
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BU of 2bji by Molmil
High Resolution Structure of myo-Inositol Monophosphatase, The Target of Lithium Therapy
Descriptor: INOSITOL-1(OR 4)-MONOPHOSPHATASE, MAGNESIUM ION
Authors:Gill, R, Mohammed, F, Badyal, R, Coates, L, Erskine, P, Thompson, D, Cooper, J, Gore, M, Wood, S.
Deposit date:2005-02-03
Release date:2005-02-11
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:High-resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy.
Acta Crystallogr. D Biol. Crystallogr., 61, 2005
4WTU
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BU of 4wtu by Molmil
Crystal structure of BACE1 in complex with 2-aminooxazoline 3-aza-4-fluoro-xanthene inhibitor 22
Descriptor: (5S)-3-(5,6-dihydro-2H-pyran-3-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)spiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazol]-2'-amine, Beta-secretase 1, GLYCEROL, ...
Authors:Whittington, D.A, Long, A.M.
Deposit date:2014-10-30
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An Orally Available BACE1 Inhibitor That Affords Robust CNS A beta Reduction without Cardiovascular Liabilities.
Acs Med.Chem.Lett., 6, 2015
6WNY
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BU of 6wny by Molmil
Crystal structure of BACE1 in complex with (Z)-fluoro-olefin containing compound 15
Descriptor: 6-[(Z)-2-{3-[(1S,5S,6S)-3-amino-5-methyl-1-(morpholine-4-carbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl}-1-fluoroethenyl]pyridine-3-carbonitrile, Beta-secretase 1, IODIDE ION
Authors:Whittington, D.A.
Deposit date:2020-04-23
Release date:2020-06-03
Last modified:2020-06-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement.
Bioorg.Med.Chem.Lett., 30, 2020
6XVF
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BU of 6xvf by Molmil
Crystal structure of bovine cytochrome bc1 in complex with tetrahydro-quinolone inhibitor JAG021
Descriptor: 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ...
Authors:Amporndanai, K, Hasnain, S.S, Antonyuk, S.V.
Deposit date:2020-01-21
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.
Front Cell Infect Microbiol, 10, 2020
5NMI
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BU of 5nmi by Molmil
Cytochrome bc1 bound to the inhibitor MJM170
Descriptor: (4aS)-2-methyl-3-(4-phenoxyphenyl)-5,6,7,8-tetrahydroquinolin-4(4aH)-one, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ARG-ASN-TRP-VAL-PRO-THR-ALA-GLN-LEU-TRP-GLY-ALA-VAL-GLY-ALA-VAL-GLY-LEU-VAL-SER-ALA-THR, ...
Authors:Capper, N.J, Antonyuk, S.V, Hasnain, S.S.
Deposit date:2017-04-05
Release date:2017-06-14
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.
Sci Rep, 6, 2016
5L9A
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BU of 5l9a by Molmil
L-threonine dehydrogenase from trypanosoma brucei.
Descriptor: ACETATE ION, L-threonine 3-dehydrogenase
Authors:Erskine, P.T, Cooper, J.B, Adjogatse, E, Kelly, J, Wood, S.P.
Deposit date:2016-06-09
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5LC1
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BU of 5lc1 by Molmil
L-threonine dehydrogenase from Trypanosoma brucei with NAD and the inhibitor pyruvate bound.
Descriptor: ACETATE ION, BETA-MERCAPTOETHANOL, L-threonine 3-dehydrogenase, ...
Authors:Erskine, P.T, Adjogatse, E, Wood, S.P, Cooper, J.B.
Deposit date:2016-06-18
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
1PPT
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BU of 1ppt by Molmil
X-RAY ANALYSIS (1.4-ANGSTROMS RESOLUTION) OF AVIAN PANCREATIC POLYPEPTIDE. SMALL GLOBULAR PROTEIN HORMONE
Descriptor: AVIAN PANCREATIC POLYPEPTIDE, ZINC ION
Authors:Blundell, T.L, Pitts, J.E, Tickle, I.J, Wood, S.P.
Deposit date:1981-01-16
Release date:1981-02-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.
Proc.Natl.Acad.Sci.Usa, 78, 1981
6B8O
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BU of 6b8o by Molmil
WT Ig-like V Domain with Phosphatidylserine
Descriptor: 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Sudom, A, Wang, Z.
Deposit date:2017-10-09
Release date:2018-06-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J. Biol. Chem., 293, 2018
5UD8
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BU of 5ud8 by Molmil
Crystal Structure of Mutant Ig-like Domain
Descriptor: Triggering receptor expressed on myeloid cells 2
Authors:Sudom, A, Min, X, Wang, Z.
Deposit date:2016-12-23
Release date:2018-04-04
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J. Biol. Chem., 293, 2018
5UD7
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BU of 5ud7 by Molmil
Crystal Structure of Wild-Type Ig-like Domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IODIDE ION, SULFATE ION, ...
Authors:Sudom, A, Min, X, Wang, Z.
Deposit date:2016-12-23
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.20002246 Å)
Cite:Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
J. Biol. Chem., 293, 2018
1G27
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BU of 1g27 by Molmil
CRYSTAL STRUCTURE OF E.COLI POLYPEPTIDE DEFORMYLASE COMPLEXED WITH THE INHIBITOR BB-3497
Descriptor: 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE, NICKEL (II) ION, POLYPEPTIDE DEFORMYLASE
Authors:Clements, J.M, Beckett, P, Brown, A, Catlin, C, Lobell, M, Palan, S, Thomas, W, Whittaker, M, Baker, P.J, Rodgers, H.F, Barynin, V, Rice, D.W, Hunter, M.G.
Deposit date:2000-10-17
Release date:2001-10-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
Antimicrob.Agents Chemother., 45, 2001
1G2A
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BU of 1g2a by Molmil
THE CRYSTAL STRUCTURE OF E.COLI PEPTIDE DEFORMYLASE COMPLEXED WITH ACTINONIN
Descriptor: ACTINONIN, NICKEL (II) ION, POLYPEPTIDE DEFORMYLASE
Authors:Clements, J.M, Beckett, P, Brown, A, Catlin, C, Lobell, M, Palan, S, Thomas, W, Whittaker, M, Baker, P.J, Rodgers, H.F, Barynin, V, Rice, D.W, Hunter, M.G.
Deposit date:2000-10-18
Release date:2001-10-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
Antimicrob.Agents Chemother., 45, 2001
4RCE
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BU of 4rce by Molmil
Crystal structure of BACE1 in complex with aminooxazoline xanthene inhibitor 2
Descriptor: (4S)-2'-(2,2-dimethylpropoxy)-7'-(pyrimidin-5-yl)spiro[1,3-oxazole-4,9'-xanthen]-2-amine, Beta-secretase 1, IODIDE ION
Authors:Whittington, D.A, Long, A.M.
Deposit date:2014-09-15
Release date:2014-12-24
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors.
J.Med.Chem., 57, 2014
4RCD
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BU of 4rcd by Molmil
Crystal structure of BACE1 in complex with a 2-aminooxazoline 4-azaxanthene inhibitor
Descriptor: (5S)-7-(2-fluoropyridin-3-yl)-3-[(3-methyloxetan-3-yl)ethynyl]spiro[chromeno[2,3-b]pyridine-5,4'-[1,3]oxazol]-2'-amine, Beta-secretase 1, GLYCEROL, ...
Authors:Whittington, D.A, Long, A.M.
Deposit date:2014-09-15
Release date:2015-01-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibitors of beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)-7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718).
J.Med.Chem., 57, 2014
4RCF
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BU of 4rcf by Molmil
Crystal structure of BACE1 in complex with 2-aminooxazoline 4-fluoroxanthene inhibitor 49
Descriptor: (4S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-fluoro-7'-(2-fluoropyridin-3-yl)spiro[1,3-oxazole-4,9'-xanthen]-2-amine, Beta-secretase 1, GLYCEROL, ...
Authors:Whittington, D.A, Long, A.M.
Deposit date:2014-09-15
Release date:2014-12-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors.
J.Med.Chem., 57, 2014
5K4W
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BU of 5k4w by Molmil
Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NADH and L-threonine refined to 1.72 angstroms
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-threonine 3-dehydrogenase, ...
Authors:Adjogatse, E.A, Erskine, P.T, Cooper, J.B.
Deposit date:2016-05-22
Release date:2018-01-10
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4U
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BU of 5k4u by Molmil
Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei showing different active site loop conformations between dimer subunits, refined to 1.9 angstroms
Descriptor: ACETATE ION, GLYCEROL, L-threonine 3-dehydrogenase, ...
Authors:Adjogatse, E.K, Cooper, J.B, Erskine, P.T.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4T
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BU of 5k4t by Molmil
Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei refined to 2.1 angstroms
Descriptor: GLYCEROL, L-threonine 3-dehydrogenase
Authors:Adjogatse, E.K, Cooper, J.B, Erskine, P.T.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4Q
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BU of 5k4q by Molmil
Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NAD+ refined to 2.3 angstroms
Descriptor: GLYCEROL, L-threonine 3-dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Adjogatse, E.K, Cooper, J.B, Erskine, P.T.
Deposit date:2016-05-21
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
5K4V
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BU of 5k4v by Molmil
Three-dimensional structure of L-threonine 3-dehydrogenase from Trypanosoma brucei bound to NAD+ refined to 2.2 angstroms
Descriptor: ACETATE ION, GLYCEROL, L-threonine 3-dehydrogenase, ...
Authors:Adjogatse, E.A, Erskine, P.T, Cooper, J.B.
Deposit date:2016-05-22
Release date:2017-11-15
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta Crystallogr D Struct Biol, 74, 2018
4DUS
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BU of 4dus by Molmil
Structure of Bace-1 (Beta-Secretase) in complex with N-((2S,3R)-1-(4-fluorophenyl)-3-hydroxy-4-((6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)butan-2-yl)acetamide
Descriptor: Beta-secretase 1, GLYCEROL, IODIDE ION, ...
Authors:Sickmier, E.A.
Deposit date:2012-02-22
Release date:2012-10-10
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase.
ACS Med Chem Lett, 3, 2012
4DH6
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BU of 4dh6 by Molmil
Structure of Bace-1 (Beta-Secretase) in Complex with (2R)-N-((2S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((S)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)-2-methoxypropanamide
Descriptor: (2R)-N-[(2S,3R)-1-(1,3-benzodioxol-5-yl)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxybutan-2-yl]-2-methoxypropanamide, Beta-secretase 1, GLYCEROL, ...
Authors:Sickmier, E.A.
Deposit date:2012-01-27
Release date:2012-04-18
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and preparation of a potent series of hydroxyethylamine containing beta-secretase inhibitors that demonstrate robust reduction of central beta-amyloid.
J.Med.Chem., 55, 2012
4DI2
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BU of 4di2 by Molmil
Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37
Descriptor: (2R)-N-{(2S,3R)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl}-2-methoxypropanamide, Beta-secretase 1, GLYCEROL
Authors:Whittington, D.A, Long, A.M.
Deposit date:2012-01-30
Release date:2012-10-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
J.Med.Chem., 55, 2012

 

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