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6GU6
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BU of 6gu6 by Molmil
CDK1/Cks2 in complex with Dinaciclib
Descriptor: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU4
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BU of 6gu4 by Molmil
CDK1/CyclinB/Cks2 in complex with CGP74514A
Descriptor: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ...
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUH
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BU of 6guh by Molmil
CDK2 in complex with AZD5438
Descriptor: 1,2-ETHANEDIOL, 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUC
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BU of 6guc by Molmil
CDK2/CyclinA in complex with SU9516
Descriptor: (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUK
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BU of 6guk by Molmil
CDK2 in complex with CGP74514A
Descriptor: Cyclin-dependent kinase 2, ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUE
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BU of 6gue by Molmil
CDK2/CyclinA in complex with AZD5438
Descriptor: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU2
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BU of 6gu2 by Molmil
CDK1/CyclinB/Cks2 in complex with Flavopiridol
Descriptor: 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUB
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BU of 6gub by Molmil
CDK2/CyclinA in complex with Flavopiridol
Descriptor: 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU3
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BU of 6gu3 by Molmil
CDK1/CyclinB/Cks2 in complex with AZD5438
Descriptor: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, ...
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GU7
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BU of 6gu7 by Molmil
CDK1/Cks2 in complex with AZD5438
Descriptor: 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6GUF
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BU of 6guf by Molmil
CDK2/CyclinA in complex with CGP74514A
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE
Authors:Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P.
Deposit date:2018-06-19
Release date:2018-12-05
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Cell Chem Biol, 26, 2019
6Q4B
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BU of 6q4b by Molmil
CDK2 in complex with FragLite13
Descriptor: 5-bromanylpyrimidine, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4J
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BU of 6q4j by Molmil
CDK2 in complex with FragLite34
Descriptor: 2-[3-(pyrimidin-4-ylamino)phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q3B
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BU of 6q3b by Molmil
CDK2 in complex with FragLite2
Descriptor: 4-IODOPYRAZOLE, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-04
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q49
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BU of 6q49 by Molmil
CDK2 in complex with FragLite6
Descriptor: 4-bromanyl-1~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4G
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BU of 6q4g by Molmil
CDK2 in complex with FragLite37
Descriptor: 2-[3-(2-azanyl-9~{H}-purin-6-yl)phenyl]ethanoic acid, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (0.98 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q3C
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BU of 6q3c by Molmil
CDK2 in complex with FragLite1
Descriptor: 4-bromo-1H-pyrazole, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-04
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q48
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BU of 6q48 by Molmil
CDK2 in complex with FragLite7
Descriptor: 4-iodanyl-3~{H}-pyridin-2-one, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4H
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BU of 6q4h by Molmil
CDK2 in complex with FragLite36
Descriptor: 2-[3-[(2-azanyl-9~{H}-purin-6-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4C
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BU of 6q4c by Molmil
CDK2 in complex with FragLite16
Descriptor: 4-bromanyl-1,8-naphthyridine, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4F
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BU of 6q4f by Molmil
CDK2 in complex with FragLite32
Descriptor: Cyclin-dependent kinase 2, PYRIDINE-2,6-DIAMINE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4A
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BU of 6q4a by Molmil
CDK2 in complex with FragLite14
Descriptor: 5-iodanylpyrimidine, CYCLIN-DEPENDENT KINASE 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4I
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BU of 6q4i by Molmil
CDK2 in complex with FragLite35
Descriptor: 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4E
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BU of 6q4e by Molmil
CDK2 in complex with FragLite33
Descriptor: 6-iodanyl-7~{H}-purin-2-amine, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019
6Q4K
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BU of 6q4k by Molmil
CDK2 in complex with FragLite38
Descriptor: (~{E})-3-[3-[(4-chlorophenyl)carbamoyl]phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, Cyclin-dependent kinase 2
Authors:Wood, D.J, Martin, M.P, Noble, M.E.M.
Deposit date:2018-12-05
Release date:2019-03-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62, 2019

 

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