Author results

5XAJ
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STRUCTURAL MIMICRY OF THE DENGUE VIRUS ENVELOPE GLYCOPROTEIN REVEALED BY THE CRYSTALLOGRAPHIC STUDY OF AN IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX.
分子名称:FabHM14c10 heavy chain, FabHM14c10 light chain, Fab E1 light chain, ...
著者Wong, Y.H., Goh, B.C., Lescar, J.
登録日2017-03-13
公開日2017-06-14
最終更新日2017-07-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex
J. Virol., 2017
5ZBI
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CRYSTAL STRUCTURE OF ASPARAGINYL ENDOPEPTIDASES FROM VIOLA CANADENSIS
分子名称:Peptide asparaginyl ligase, SODIUM ION
著者Wong, Y.H., Lescar, J.
登録日2018-02-12
公開日2018-05-09
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Crystal structure of Peptide asparaginyl ligase from Viola canadensis
To Be Published
5AAM
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STRUCTURE OF A REDESIGNED CROSS-REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY
分子名称:SCFV513, ENVELOPE PROTEIN
著者Wong, Y.H., Robinson, L.N., Lescar, J., Sasisekharan, R.
登録日2015-07-27
公開日2015-08-05
最終更新日2015-08-19
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.
Cell(Cambridge,Mass.), 162, 2015
5GM8
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
分子名称:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ, SINEFUNGIN
著者Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
登録日2016-07-13
公開日2016-10-26
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMB
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
分子名称:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
著者Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
登録日2016-07-13
公開日2016-10-26
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5GMC
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METHYLATION AT POSITION 32 OF TRNA CATALYZED BY TRMJ ALTERS OXIDATIVE STRESS RESPONSE IN PSEUDOMONAS AERUIGINOSA
分子名称:tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ
著者Jaroensuk, J., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Liew, C.W., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
登録日2016-07-13
公開日2016-10-26
最終更新日2017-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Methylation at position 32 of tRNA catalyzed by TrmJ alters oxidative stress response in Pseudomonas aeruginosa.
Nucleic Acids Res., 44, 2016
5WYQ
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
分子名称:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYLMETHIONINE
著者Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W., McBee, M.E., Maenpuen, S., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M., Chaiyen, P.
登録日2017-01-15
公開日2017-12-20
最終更新日2019-10-02
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
5WYR
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
分子名称:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN
著者Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
登録日2017-01-15
公開日2017-12-20
最終更新日2019-10-02
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 2019
6JKI
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CRYSTAL STRUCTURE AND CATALYTIC MECHANISM OF THE ESSENTIAL M1G37 TRNA METHYLTRANSFERASE TRMD FROM PSEUDOMONAS AERUGINOSA
分子名称:tRNA (guanine-N(1)-)-methyltransferase, SINEFUNGIN, GLYCEROL, ...
著者Jaroensuk, J., Liew, C.W., Atichartpongkul, S., Chionh, Y.H., Wong, Y.H., Zhong, W.H., McBee, M.E., Thongdee, N., Prestwich, E.G., DeMott, M.S., Mongkolsuk, S., Dedon, P.C., Lescar, J., Fuangthong, M.
登録日2019-03-01
公開日2019-07-03
最終更新日2019-10-30
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase TrmD fromPseudomonas aeruginosa.
Rna, 25, 2019
5FSW
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RNA DEPENDENT RNA POLYMERASE QDE-1 FROM THIELAVIA TERRESTRIS
分子名称:RNA DEPENDENT RNA POLYMERASE QDE-1
著者Qian, X., Hamid, F.M., El Sahili, A., Darwis, D.A., Wong, Y.H., Bhushan, S., Makeyev, E.V., Lescar, J.
登録日2016-01-08
公開日2016-03-02
最終更新日2016-05-11
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Functional Evolution in Orthologous Cell-Encoded RNA-Dependent RNA Polymerases
J.Biol.Chem., 291, 2016
5H0I
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NAME TO BE RELEASED WHEN PUBLISHED
分子名称:Asparaginyl endopeptidase
著者Yang, R., Wong, Y.H., Lescar, J., Wu, B.
登録日2016-10-04
公開日2017-03-29
最終更新日2017-05-03
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献Engineering a Catalytically Efficient Recombinant Protein Ligase
J. Am. Chem. Soc., 139, 2017
6ID4
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DEFINING THE STRUCTURAL BASIS FOR HUMAN ALLOANTIBODY BINDING TO HUMAN LEUKOCYTE ANTIGEN ALLELE HLA-A*11:01
分子名称:HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, ...
著者Lescar, J., Wong, Y.H., Liew, C.W., Gu, Y., MacAry, P.A.
登録日2018-09-08
公開日2019-02-06
最終更新日2019-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.
Nat Commun, 10, 2019
5ZHI
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APO CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:tRNA (guanine-N(1)-)-methyltransferase
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-06
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHJ
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH S-ADENOSYL HOMOCYSTEINE (SAH)
分子名称:tRNA (guanine-N(1)-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, GLYCEROL
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-06
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHK
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, N-[(4-{[cyclohexyl(ethyl)amino]methyl}phenyl)methyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-06
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHL
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-06
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHM
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(diethylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide, S-ADENOSYLMETHIONINE
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-06
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
5ZHN
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, N-({4-[(octylamino)methyl]phenyl}methyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2018-03-13
公開日2019-03-27
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOE
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CRYSTAL STRUCTURE OF TRMD FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide, PHOSPHATE ION, ...
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2019-03-20
公開日2019-09-04
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
6JOF
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CRYSTAL STRUCTURE OF TRMD FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACTIVE-SITE INHIBITOR
分子名称:tRNA (guanine-N(1)-)-methyltransferase, ~{N}-[[4-[(4-azanylpiperidin-1-yl)methyl]phenyl]methyl]-4-oxidanylidene-3~{H}-thieno[2,3-d]pyrimidine-5-carboxamide
著者Zhong, W., Pasunooti, K.K., Balamkundu, S., Wong, Y.W., Nah, Q., Liu, C.F., Lescar, J., Dedon, P.C.
登録日2019-03-20
公開日2019-09-04
最終更新日2019-09-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J.Med.Chem., 62, 2019
3OUO
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STRUCTURE OF THE NUCLEOPROTEIN FROM RIFT VALLEY FEVER VIRUS
分子名称:Nucleoprotein, NITRITE ION
著者Ferron, F., Danek, E.I., Li, Z., Luo, D., Wong, Y.H., Coutard, B., Lantez, V., Charrel, R., Canard, B., Walz, T., Lescar, J.
登録日2010-09-15
公開日2011-05-25
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
3OV9
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STRUCTURE OF THE NUCLEOPROTEIN FROM RIFT VALLEY FEVER VIRUS
分子名称:Nucleoprotein, NITRITE ION, SODIUM ION
著者Ferron, F., Danek, E.I., Li, Z., Luo, D., Wong, Y.H., Coutard, B., Lantez, V., Charrel, R., Canard, B., Walz, T., Lescar, J.
登録日2010-09-16
公開日2011-05-25
最終更新日2013-08-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes
Plos Pathog., 7, 2011
5AAW
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STRUCTURE OF A REDESIGNED CROSS-REACTIVE ANTIBODY TO DENGUE VIRUS WITH INCREASED IN VIVO POTENCY
分子名称:SCFV513, DENGUE SEROTYPE 4 ENVELOPE PROTEIN DOMAIN 3
著者Wong, Y., Robinson, L., Lescar, J., Sasisekharan, R.
登録日2015-07-30
公開日2015-09-30
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (3.27 Å)
主引用文献Structure-Guided Design of an Anti-Dengue Antibody Directed to a Non-Immunodominant Epitope.
Cell(Cambridge,Mass.), 162, 2015
5XGB
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CRYSTAL STRUCTURE OF THE PAS-GGDEF-EAL DOMAIN OF PA0861 FROM PSEUDOMONAS AERUGINOSA
分子名称:Uncharacterized protein
著者Liu, C., Liew, C.W., Sreekanth, R., Lescar, J.
登録日2017-04-13
公開日2017-12-20
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
5XGD
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CRYSTAL STRUCTURE OF THE PAS-GGDEF-EAL DOMAIN OF PA0861 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH GTP
分子名称:Uncharacterized protein PA0861, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
著者Liu, C., Liew, C.W., Sreekanth, R., Lescar, J.
登録日2017-04-13
公開日2017-12-20
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
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