Author results

1NF1
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THE GAP RELATED DOMAIN OF NEUROFIBROMIN
Descriptor:PROTEIN (NEUROFIBROMIN)
Authors:Scheffzek, K., Ahmadian, M.R., Wiesmueller, L., Kabsch, W., Stege, P., Schmitz, F., Wittinghofer, A.
Deposit date:1998-07-08
Release date:1999-07-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of the GAP-related domain from neurofibromin and its implications.
EMBO J., 17, 1998
1WQ1
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RAS-RASGAP COMPLEX
Descriptor:H-RAS, P120GAP, MAGNESIUM ION, ...
Authors:Scheffzek, K., Ahmadian, M.R., Kabsch, W., Wiesmueller, L., Lautwein, A., Schmitz, F., Wittinghofer, A.
Deposit date:1997-07-03
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science, 277, 1997
1K5D
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CRYSTAL STRUCTURE OF RAN-GPPNHP-RANBP1-RANGAP COMPLEX
Descriptor:GTP-binding nuclear protein RAN, Ran-specific GTPase-activating protein, Ran GTPase activating protein 1, ...
Authors:Seewald, M.J., Koerner, C., Wittinghofer, A., Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
1K5G
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CRYSTAL STRUCTURE OF RAN-GDP-ALFX-RANBP1-RANGAP COMPLEX
Descriptor:GTP-binding nuclear protein RAN, Ran-specific GTPase-activating protein, Ran GTPase activating protein 1, ...
Authors:Seewald, M.J., Koerner, C., Wittinghofer, A., Vetter, I.R.
Deposit date:2001-10-10
Release date:2002-02-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:RanGAP mediates GTP hydrolysis without an arginine finger.
Nature, 415, 2002
5P21
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REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Pai, E.F., Wittinghofer, A., Kabsch, W.
Deposit date:1990-04-30
Release date:1992-01-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
EMBO J., 9, 1990
1GUA
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HUMAN RAP1A, RESIDUES 1-167, DOUBLE MUTANT (E30D,K31E) COMPLEXED WITH GPPNHP AND THE RAS-BINDING-DOMAIN OF HUMAN C-RAF1, RESIDUES 51-131
Descriptor:RAP1A, C-RAF1, MAGNESIUM ION, ...
Authors:Nassar, N., Wittinghofer, A.
Deposit date:1996-06-18
Release date:1997-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Ras/Rap effector specificity determined by charge reversal.
Nat.Struct.Biol., 3, 1996
821P
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THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Scheidig, A.J., Krengel, U., Pai, E.F., Kabsch, W., Wittinghofer, A., Goody, R.S.
Deposit date:1993-03-29
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1AGP
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THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLY-12 MUTANT OF P21-H-RAS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Franken, S.M., Scheidig, A.J., Wittinghofer, A., Goody, R.S.
Deposit date:1993-03-29
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1CLU
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H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
Descriptor:TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A., Scheffzek, K.
Deposit date:1999-05-03
Release date:1999-05-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
1GNP
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1RVD
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H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
Descriptor:TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A., Scheffzek, K.
Deposit date:1999-05-03
Release date:1999-05-28
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
2B8W
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CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF HUMAN GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH GMP/ALF4
Descriptor:Interferon-induced guanylate-binding protein 1, MAGNESIUM ION, TETRAFLUOROALUMINATE ION, ...
Authors:Ghosh, A., Praefcke, G.J.K., Renault, L., Wittinghofer, A., Herrmann, C.
Deposit date:2005-10-10
Release date:2006-03-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature, 440, 2006
2B92
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CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF HUMAN GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH GDP/ALF3
Descriptor:Interferon-induced guanylate-binding protein 1, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Ghosh, A., Praefcke, G.J.K., Renault, L., Wittinghofer, A., Herrmann, C.
Deposit date:2005-10-10
Release date:2006-03-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature, 440, 2006
2BC9
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CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF HUMAN GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH NON-HYDROLYSABLE GTP ANALOGUE GPPNHP
Descriptor:Interferon-induced guanylate-binding protein 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Ghosh, A., Praefcke, G.J.K., Renault, L., Wittinghofer, A., Herrmann, C.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature, 440, 2006
2D4H
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CRYSTAL-STRUCTURE OF THE N-TERMINAL LARGE GTPASE DOMAIN OF HUMAN GUANYLATE BINDING PROTEIN 1 (HGBP1) IN COMPLEX WITH GMP
Descriptor:Interferon-induced guanylate-binding protein 1, GUANOSINE-5'-MONOPHOSPHATE
Authors:Ghosh, A., Praefcke, G.J.K., Renault, L., Wittinghofer, A., Herrmann, C.
Deposit date:2005-10-19
Release date:2006-03-07
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.
Nature, 440, 2006
521P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Schlichting, I., Krengel, U., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1PLJ
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLK
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLL
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
Descriptor:C-H-RAS P21 PROTEIN, GUANOSINE-5'-DIPHOSPHATE
Authors:Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
Deposit date:1994-03-13
Release date:1994-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1GNQ
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1GNR
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
Descriptor:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
Authors:Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
Deposit date:1995-05-11
Release date:1995-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1WER
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RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
Descriptor:P120GAP
Authors:Scheffzek, K., Lautwein, A., Kabsch, W., Ahmadian, M.R., Wittinghofer, A.
Deposit date:1996-11-20
Release date:1997-12-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature, 384, 1996
221P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
Descriptor:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Krengel, U., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
Deposit date:1991-06-06
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
2NTX
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PRONE8
Descriptor:Emb|CAB41934.1
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007
2NTY
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ROP4-GDP-PRONE8
Descriptor:Emb|CAB41934.1, Rac-like GTP-binding protein ARAC5, GUANOSINE-5'-DIPHOSPHATE
Authors:Thomas, C., Fricke, I., Scrima, A., Berken, A., Wittinghofer, A.
Deposit date:2006-11-08
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions
Mol.Cell, 25, 2007