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3DLL
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BU of 3dll by Molmil
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Descriptor: 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Wilson, D.N, Schluenzen, F, Harms, J.M, Starosta, A.L, Connell, S.R, Fucini, P.
Deposit date:2008-06-27
Release date:2008-09-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Proc.Natl.Acad.Sci.Usa, 105, 2008
1Y69
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BU of 1y69 by Molmil
RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L16, 50S ribosomal protein L27, ...
Authors:Wilson, D.N, Schluenzen, F, Harms, J.M, Yoshida, T, Ohkubo, T, Albrecht, R, Buerger, J, Kobayashi, Y, Fucini, P.
Deposit date:2004-12-04
Release date:2005-03-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:X-ray crystallography on ribosome recycling: mechanism of binding and action of RRF on the 50S ribosomal subunit
EMBO J., 24, 2005
6HTQ
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BU of 6htq by Molmil
Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Wilson, D.N, Abdelshahid, M.
Deposit date:2018-10-04
Release date:2019-10-23
Last modified:2020-09-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Cell Rep, 32, 2020
8A63
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BU of 8a63 by Molmil
Cryo-EM structure of Listeria monocytogenes 50S ribosomal subunit.
Descriptor: 1,4-DIAMINOBUTANE, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Koller, T.O, Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2022-06-16
Release date:2022-11-02
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Nucleic Acids Res., 50, 2022
8A57
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BU of 8a57 by Molmil
Cryo-EM structure of HflXr bound to the Listeria monocytogenes 50S ribosomal subunit.
Descriptor: 1,4-DIAMINOBUTANE, 23S ribosomal RNA, 50S ribosomal protein L11, ...
Authors:Koller, T.O, Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2022-06-14
Release date:2022-11-02
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Nucleic Acids Res., 50, 2022
8A5I
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BU of 8a5i by Molmil
Cryo-EM structure of Lincomycin bound to the Listeria monocytogenes 50S ribosomal subunit.
Descriptor: 1,4-DIAMINOBUTANE, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:Koller, T.O, Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2022-06-15
Release date:2022-11-02
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Nucleic Acids Res., 50, 2022
4V6I
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BU of 4v6i by Molmil
Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein RACK1 (RACK1), ...
Authors:Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R.
Deposit date:2010-10-12
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Proc.Natl.Acad.Sci.USA, 107, 2010
5NWY
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BU of 5nwy by Molmil
2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Su, T, Cheng, J, Sohmen, D, Hedman, R, Berninghausen, O, von Heijne, G, Wilson, D.N, Beckmann, R.
Deposit date:2017-05-08
Release date:2017-07-19
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling.
Elife, 6, 2017
5O2R
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BU of 5o2r by Molmil
Cryo-EM structure of the proline-rich antimicrobial peptide Api137 bound to the terminating ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Graf, M, Berninghausen, O, Beckmann, R, Wilson, D.N.
Deposit date:2017-05-22
Release date:2017-07-26
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.
Nat. Struct. Mol. Biol., 24, 2017
7P7Q
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BU of 7p7q by Molmil
E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7T
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BU of 7p7t by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7U
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BU of 7p7u by Molmil
E. faecalis 70S ribosome with P-tRNA, state IV
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7S
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BU of 7p7s by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-02-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
7P7R
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BU of 7p7r by Molmil
PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Crowe-McAuliffe, C, Wilson, D.N.
Deposit date:2021-07-20
Release date:2022-03-23
Last modified:2022-04-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics.
Nat Commun, 13, 2022
4V6W
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BU of 4v6w by Molmil
Structure of the D. melanogaster 80S ribosome
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ...
Authors:Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R.
Deposit date:2013-02-27
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structures of the human and Drosophila 80S ribosome.
Nature, 497, 2013
4V61
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BU of 4v61 by Molmil
Homology model for the Spinach chloroplast 30S subunit fitted to 9.4A cryo-EM map of the 70S chlororibosome.
Descriptor: 16S rRNA, 23S rRNA, 4.8S rRNA, ...
Authors:Sharma, M.R, Wilson, D.N, Datta, P.P, Barat, C, Schluenzen, F, Fucini, P, Agrawal, R.K.
Deposit date:2007-11-09
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (9.4 Å)
Cite:Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins
Proc.Natl.Acad.Sci.Usa, 104, 2007
4V6U
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BU of 4v6u by Molmil
Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10P, ...
Authors:Armache, J.-P, Anger, A.M, Marquez, V, Frankenberg, S, Froehlich, T, Villa, E, Berninghausen, O, Thomm, M, Arnold, G.J, Beckmann, R, Wilson, D.N.
Deposit date:2012-08-09
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution.
Nucleic Acids Res., 41, 2013
4V6X
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BU of 4v6x by Molmil
Structure of the human 80S ribosome
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Anger, A.M, Armache, J.-P, Berninghausen, O, Habeck, M, Subklewe, M, Wilson, D.N, Beckmann, R.
Deposit date:2013-02-27
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Structures of the human and Drosophila 80S ribosome.
Nature, 497, 2013
4V5N
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BU of 4v5n by Molmil
tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST)
Descriptor: 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T.
Deposit date:2010-10-21
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
4V7E
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BU of 4v7e by Molmil
Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S10E, ...
Authors:Barrio-Garcia, C, Armache, J.-P, Jarasch, A, Anger, A.M, Villa, E, Becker, T, Bhushan, S, Jossinet, F, Habeck, M, Dindar, G, Franckenberg, S, Marquez, V, Mielke, T, Thomm, M, Berninghausen, O, Beatrix, B, Soeding, J, Westhof, E, Wilson, D.N, Beckmann, R.
Deposit date:2013-11-22
Release date:2014-07-09
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.
Nature, 506, 2014
8QCQ
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BU of 8qcq by Molmil
B. subtilis ApdA-stalled ribosomal complex
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Morici, M, Wilson, D.N.
Deposit date:2023-08-28
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Novel arrest peptides induce ribosome stalling by short circuiting the ribosomal peptidyltransferase activity
To Be Published, 2024
8QBT
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BU of 8qbt by Molmil
E. coli ApdP-stalled ribosomal complex
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S11, ...
Authors:Morici, M, Wilson, D.N.
Deposit date:2023-08-25
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Novel arrest peptides induce ribosome stalling by short circuiting the ribosomal peptidyltransferase activity
To Be Published, 2024
8QOA
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BU of 8qoa by Molmil
Structure of SecM-stalled Escherichia coli 70S ribosome
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ...
Authors:Gersteuer, F, Morici, M, Wilson, D.N.
Deposit date:2023-09-28
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2 Å)
Cite:SecM adopts alpha-helical conformation in the ribosomal exit tunnel and traps a pre-peptide bond formation state of the ribosome
To Be Published, 2024
7OTC
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BU of 7otc by Molmil
Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B
Descriptor: 1,4-DIAMINOBUTANE, 16S ribosomal RNA, 23S ribosomal RNA, ...
Authors:Wieland, M, Koller, T.O, Wilson, D.N.
Deposit date:2021-06-10
Release date:2022-05-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The cyclic octapeptide antibiotic argyrin B inhibits translation by trapping EF-G on the ribosome during translocation.
Proc.Natl.Acad.Sci.USA, 119, 2022
7JQL
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BU of 7jql by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Mardirossian, M, Sola, R, Beckert, B, Valencic, E, Collis, D.W.P, Borisek, J, Armas, F, Di Stasi, A, Buchmann, J, Syroegin, E.A, Polikanov, Y.S, Magistrato, A, Hilpert, K, Wilson, D.N, Scocchi, M.
Deposit date:2020-08-11
Release date:2020-08-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Peptide Inhibitors of Bacterial Protein Synthesis with Broad Spectrum and SbmA-Independent Bactericidal Activity against Clinical Pathogens.
J.Med.Chem., 63, 2020

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