Author results

5WAV
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FC ABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION-MAKING IN ANTIBODY DRUG DISCOVERY.
分子名称:Immunoglobulin gamma-1 heavy chain,Immunoglobulin gamma-1 heavy chain, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
著者Williams, S.P., Reid, R.A., Convery, M.A.
登録日2017-06-27
公開日2017-11-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery.
To Be Published
5WAW
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FCABVANCE: INCREASING OUR KNOWLEDGE OF ANTIBODY STRUCTURAL SPACE TO ENABLE FASTER AND BETTER DECISION-MAKING IN ANTIBODY DRUG DISCOVERY
分子名称:fAb Light Chain, fAb Heavy Chain, ZINC ION, ...
著者Williams, S.P., Reid, R.A., Convery, M.
登録日2017-06-27
公開日2017-11-08
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献AbVance: Increasing our knowledge of antibody structural space to enable faster and better decision-making in antibody drug discovery.
Not Published
1A28
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HORMONE-BOUND HUMAN PROGESTERONE RECEPTOR LIGAND-BINDING DOMAIN
分子名称:PROGESTERONE RECEPTOR, PROGESTERONE
著者Sigler, P.B., Williams, S.P.
登録日1998-01-19
公開日1998-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Atomic structure of progesterone complexed with its receptor.
Nature, 393, 1998
1SQN
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PROGESTERONE RECEPTOR LIGAND BINDING DOMAIN WITH BOUND NORETHINDRONE
分子名称:progesterone receptor, (14beta,17alpha)-17-ethynyl-17-hydroxyestr-4-en-3-one
著者Williams, S.P., Madauss, K.P., Deng, J.-S., Austin, R.J.H., Lambert, M.H., McLay, I., Pritchard, J., Short, S.A., Stewart, E.L., Uings, I.J.
登録日2004-03-19
公開日2004-07-27
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.451 Å)
主引用文献Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
3DCT
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FXR WITH SRC1 AND GW4064
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid
著者Williams, S.P., Madauss, K.P.
登録日2008-06-04
公開日2008-08-12
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Bioorg.Med.Chem.Lett., 18, 2008
3DCU
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FXR WITH SRC1 AND GSK8062
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, 6-(4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)naphthalene-1-carboxylic acid
著者Williams, S.P., Madauss, K.P.
登録日2008-06-04
公開日2008-08-12
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Bioorg.Med.Chem.Lett., 18, 2008
3DT3
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HUMAN ESTROGEN RECEPTOR ALPHA LBD WITH GW368
分子名称:Estrogen receptor, 5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7-methylnaphthalen-2-ol
著者Williams, S.P., Miller, A.B.
登録日2008-07-14
公開日2008-09-09
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands.
Bioorg.Med.Chem.Lett., 18, 2008
3FF6
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HUMAN ACC2 CT DOMAIN WITH CP-640186
分子名称:Acetyl-CoA carboxylase 2, (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE
著者Williams, S.P., Madauss, K.P., Burkhart, W.A.
登録日2008-12-02
公開日2009-05-19
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Acta Crystallogr.,Sect.D, 65, 2009
3HC5
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FXR WITH SRC1 AND GSK826
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, 3-(6-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1-benzothiophen-2-yl)benzoic acid, ...
著者Williams, S.P., Madauss, K.P.
登録日2009-05-05
公開日2009-07-21
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg.Med.Chem.Lett., 19, 2009
3HC6
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FXR WITH SRC1 AND GSK088
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, 3-[(5-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-1H-indol-1-yl)methyl]benzoic acid, ...
著者Williams, S.P., Madauss, K.P.
登録日2009-05-05
公開日2009-07-21
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorg.Med.Chem.Lett., 19, 2009
3PLZ
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HUMAN LRH1 LBD BOUND TO GR470
分子名称:FTZ-F1 related protein, Nuclear receptor coactivator 2, (3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-2,3,6,6a-tetrahydropentalen-3a(1H)-amine, ...
著者Williams, S.P., Xu, R., Zuercher, W.J.
登録日2010-11-15
公開日2011-03-30
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2).
J.Med.Chem., 54, 2011
3RUT
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FXR WITH SRC1 AND GSK359
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ...
著者Williams, S.P., Madauss, K.P.
登録日2011-05-05
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.
Bioorg.Med.Chem.Lett., 21, 2011
3RUU
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FXR WITH SRC1 AND GSK237
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ...
著者Williams, S.P., Madauss, K.P.
登録日2011-05-05
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.502 Å)
主引用文献Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.
Bioorg.Med.Chem.Lett., 21, 2011
3RVF
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FXR WITH SRC1 AND GSK2034
分子名称:Bile acid receptor, Nuclear receptor coactivator 1, SULFATE ION, ...
著者Williams, S.P., Madauss, K.P.
登録日2011-05-06
公開日2011-09-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Conformationally constrained farnesoid X receptor (FXR) agonists: Alternative replacements of the stilbene.
Bioorg.Med.Chem.Lett., 21, 2011
4PIV
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HUMAN FATTY ACID SYNTHASE PSI/KR TRI-DOMAIN WITH NADPH AND GSK2194069
分子名称:Fatty acid synthase, CACODYLATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Williams, S.P., Wang, L., Brown, K.K., Parrish, C.A., Hardwicke, M.A.
登録日2014-05-09
公開日2014-07-23
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site.
Nat.Chem.Biol., 10, 2014
6CMJ
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HUMAN CAMKK2 WITH GSK650393
分子名称:Calcium/calmodulin-dependent protein kinase kinase 2, 2-(2-methylpropyl)-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid, FORMIC ACID, ...
著者Williams, S.P., Reid, R.A., Price, D.J., Drewry, D.H.
登録日2018-03-05
公開日2018-04-04
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model.
Bioorg. Med. Chem. Lett., 28, 2018
1YOK
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CRYSTAL STRUCTURE OF HUMAN LRH-1 BOUND WITH TIF-2 PEPTIDE AND PHOSPHATIDYLGLYCEROL
分子名称:Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
著者Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
登録日2005-01-27
公開日2005-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
1YOW
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HUMAN STEROIDOGENIC FACTOR 1 LBD WITH BOUND CO-FACTOR PEPTIDE
分子名称:Steroidogenic factor 1, TIF2 peptide, PHOSPHATIDYL ETHANOL
著者Krylova, I.N., Sablin, E.P., Xu, R.X., Waitt, G.M., Juzumiene, D., Williams, J.D., Ingraham, H.A., Willson, T.M., Williams, S.P., Montana, V., Madauss, K.P., Moore, J., Bynum, J.M., Lebedeva, L., MacKay, J.A., Suzawa, M., Guy, R.K., Thornton, J.W.
登録日2005-01-28
公開日2005-05-10
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
1LV2
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HEPATOCYTE NUCLEAR FACTOR 4 IS A TRANSCRIPTION FACTOR THAT CONSTITUTIVELY BINDS FATTY ACIDS
分子名称:Hepatocyte nuclear factor 4-gamma, PALMITIC ACID
著者Wisely, B., Miller, A.B., Davis, R.G., Spitzer, T., Shearer, B., Moore, J.T., Johnson, R., Sefler, A., Willson, T.M., Williams, S.P.
登録日2002-05-24
公開日2002-12-18
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids.
Structure, 10, 2002
1NDE
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ESTROGEN RECEPTOR BETA WITH SELECTIVE TRIAZINE MODULATOR
分子名称:Estrogen receptor beta, 4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL
著者Henke, B.R., Consler, T.G., Go, N., Hale, R.L., Hohman, D.R., Jones, S.A., Lu, A.T., Moore, L.B., Moore, J.T., Orband-Miller, L.A., Robinett, R.G., Shearin, J., Spearing, P.K., Stewart, E.L., Turnbull, P.S., Weaver, S.L., Williams, S.P., Wisely, G.B., Lambert, M.H.
登録日2002-12-09
公開日2002-12-18
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor beta
J.Med.Chem., 45, 2002
1SR7
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PROGESTERONE RECEPTOR HORMONE BINDING DOMAIN WITH BOUND MOMETASONE FUROATE
分子名称:Progesterone receptor, MOMETASONE FUROATE, SULFATE ION, ...
著者Madauss, K.P., Deng, S.-J., Austin, R.J., Lambert, M.H., McLay, I., Pritchard, J., Short, S.A., Stewart, E.L., Uings, I.J., Williams, S.P.
登録日2004-03-22
公開日2004-06-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes
J.Med.Chem., 47, 2004
2AA2
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MINERALOCORTICOID RECEPTOR WITH BOUND ALDOSTERONE
分子名称:Mineralocorticoid receptor, B-OCTYLGLUCOSIDE, SULFATE ION, ...
著者Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
登録日2005-07-13
公開日2005-07-26
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA5
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MINERALOCORTICOID RECEPTOR WITH BOUND PROGESTERONE
分子名称:Mineralocorticoid receptor, PROGESTERONE
著者Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
登録日2005-07-13
公開日2005-07-26
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA6
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MINERALOCORTICOID RECEPTOR S810L MUTANT WITH BOUND PROGESTERONE
分子名称:Mineralocorticoid receptor, PROGESTERONE
著者Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
登録日2005-07-13
公開日2005-07-26
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
2AA7
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MINERALOCORTICOID RECEPTOR WITH BOUND DEOXYCORTICOSTERONE
分子名称:Mineralocorticoid receptor, SULFATE ION, DESOXYCORTICOSTERONE, ...
著者Bledsoe, R.K., Madauss, K.P., Holt, J.A., Apolito, C.J., Lambert, M.H., Pearce, K.H., Stanley, T.B., Stewart, E.L., Trump, R.P., Willson, T.M., Williams, S.P.
登録日2005-07-13
公開日2005-07-26
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor
J.Biol.Chem., 280, 2005
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