Author results

1J01
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CRYSTAL STRUCTURE OF THE XYLANASE CEX WITH XYLOBIOSE-DERIVED INHIBITOR ISOFAGOMINE LACTAM
Descriptor:beta-1,4-xylanase, 3-HYDROXY-4-(3,4,5-TRIHYDROXY-TETRAHYDRO-PYRAN-2-YLOXY)-PIPERIDIN-2-ONE
Authors:Williams, S.J., Notenboom, V., Wicki, J., Rose, D.R., Withers, S.G.
Deposit date:2002-10-25
Release date:2002-11-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A New, Simple, High-Affinity Glycosidase Inhibitor: Analysis of Binding through X-ray Crystallography, Mutagenesis, and Kinetic Analysis
J.Am.Chem.Soc., 122, 2000
1M03
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MUTANT STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE (D313A) IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2002-12-11
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
1M04
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MUTANT STREPTOMYCES PLICATUS BETA-HEXOSAMINIDASE (D313N) IN COMPLEX WITH PRODUCT (GLCNAC)
Descriptor:Beta-N-acetylhexosaminidase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G.
Deposit date:2002-06-11
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state.
J.Biol.Chem., 277, 2002
4C6R
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM THE ARABIDOPSIS THALIANA DISEASE RESISTANCE PROTEIN RPS4
Descriptor:DISEASE RESISTANCE PROTEIN RPS4
Authors:Williams, S.J., Sohn, K.H., Wan, L., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.
Deposit date:2013-09-19
Release date:2014-05-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
4C6T
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CRYSTAL STRUCTURE OF THE RPS4 AND RRS1 TIR DOMAIN HETERODIMER
Descriptor:PROBABLE WRKY TRANSCRIPTION FACTOR 52, DISEASE RESISTANCE PROTEIN RPS4, MALONIC ACID
Authors:Williams, S.J., Sohn, K.H., Wan, L., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.
Deposit date:2013-09-19
Release date:2014-05-28
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
5KU7
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM THE MUSCADINIA ROTUNDIFOLIA DISEASE RESISTANCE PROTEIN RPV1
Descriptor:TIR-NB-LRR type resistance protein RPV1, MALONIC ACID
Authors:Williams, S.J., Ericsson, D.J., Kobe, B.
Deposit date:2016-07-12
Release date:2017-02-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of the TIR Domain from the Grape NLR Protein RPV1.
Front Plant Sci, 7, 2016
4C6S
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM THE ARABIDOPSIS THALIANA DISEASE RESISTANCE PROTEIN RRS1
Descriptor:PROBABLE WRKY TRANSCRIPTION FACTOR 52, GLYCEROL, SULFATE ION, ...
Authors:Wan, L., Williams, S.J., Sohn, K.H., Bernoux, M., Ma, Y., Segonzac, C., Ve, T., Sarris, P., Ericsson, D.J., Saucet, S.B., Zhang, X., Parker, J., Dodds, P.N., Jones, J.D.G., Kobe, B.
Deposit date:2013-09-19
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor.
Science, 344, 2014
5T1Y
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MLA10 COILED-COIL FRAGMENT
Descriptor:MLA10, TRIETHYLENE GLYCOL
Authors:Williams, S.J., Kobe, B., Bentham, A., Ericsson, D.J.
Deposit date:2016-08-22
Release date:2016-11-02
Last modified:2016-11-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins.
Proc.Natl.Acad.Sci.USA, 2016
4ACY
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SELENOMETHIONINE DERIVATIVE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL, FORMIC ACID
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4ACZ
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES THETAIOTAOMICRON
Descriptor:ENDO-ALPHA-MANNOSIDASE, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD0
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTERIODES THETAIOTAOMICRON IN COMPLEX WITH BIS-TRIS-PROPANE
Descriptor:ENDO-ALPHA-MANNOSIDASE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD1
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS
Descriptor:GLYCOSYL HYDROLASE FAMILY 71
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD2
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-ISOFAGOMINE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, ALPHA-D-GLUCOSE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD3
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-DEOXYMANNOJIRIMYCIN
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, ALPHA-D-GLUCOSE, 1-DEOXYMANNOJIRIMYCIN
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD4
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-ISOFAGOMINE AND ALPHA-1,2- MANNOBIOSE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, ALPHA-D-GLUCOSE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, ...
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4AD5
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STRUCTURE OF THE GH99 ENDO-ALPHA-MANNOSIDASE FROM BACTEROIDES XYLANISOLVENS IN COMPLEX WITH GLUCOSE-1,3-DEOXYMANNOJIRIMYCIN AND ALPHA-1,2-MANNOBIOSE
Descriptor:GLYCOSYL HYDROLASE FAMILY 71, ALPHA-D-GLUCOSE, 1-DEOXYMANNOJIRIMYCIN, ...
Authors:Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stuetz, A.E., Butters, T.D., Williams, S.J., Davies, G.J.
Deposit date:2011-12-21
Release date:2012-02-01
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Mechanistic Insight Into N-Glycan Processing by Endo-Alpha-Mannosidase.
Proc.Natl.Acad.Sci.USA, 109, 2012
4CD4
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THE STRUCTURE OF GH26 BETA-MANNANASE CJMAN26C FROM CELLVIBRIO JAPONICUS IN COMPLEX WITH MANIFG
Descriptor:ENDO-1,4-BETA MANNANASE, PUTATIVE, MAN26C, ...
Authors:Williams, R.J., Iglesias-Fernandez, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J.
Deposit date:2013-10-30
Release date:2014-04-02
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
Angew.Chem.Int.Ed.Engl., 53, 2014
4CD5
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THE STRUCTURE OF GH26 BETA-MANNANASE CJMAN26C FROM CELLVIBRIO JAPONICUS IN COMPLEX WITH MANMIM
Descriptor:ENDO-1,4-BETA MANNANASE, PUTATIVE, MAN26C, ...
Authors:Williams, R.J., Iglesias-Fernandez, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J.
Deposit date:2013-10-30
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
Angew.Chem.Int.Ed.Engl., 53, 2014
4CD6
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THE STRUCTURE OF GH113 BETA-MANNANASE AAMANA FROM ALICYCLOBACILLUS ACIDOCALDARIUS IN COMPLEX WITH MANIFG
Descriptor:ENDO-BETA-1,4-MANNANASE, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, BETA-D-MANNOSE
Authors:Williams, R.J., Iglesias-Fernandez, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J.
Deposit date:2013-10-30
Release date:2014-04-02
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
Angew.Chem.Int.Ed.Engl., 53, 2014
4CD7
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THE STRUCTURE OF GH113 BETA-MANNANASE AAMANA FROM ALICYCLOBACILLUS ACIDOCALDARIUS IN COMPLEX WITH MANIFG AND BETA-1,4-MANNOBIOSE
Descriptor:ENDO-BETA-1,4-MANNANASE, ALPHA-D-MANNOSE, BETA-D-MANNOSE, ...
Authors:Williams, R.J., Iglesias-Fernandez, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J.
Deposit date:2013-10-30
Release date:2014-04-02
Last modified:2015-07-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
Angew.Chem.Int.Ed.Engl., 53, 2014
4CD8
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THE STRUCTURE OF GH113 BETA-MANNANASE AAMANA FROM ALICYCLOBACILLUS ACIDOCALDARIUS IN COMPLEX WITH MANMIM
Descriptor:ENDO-BETA-1,4-MANNANASE, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, BETA-D-MANNOSE
Authors:Williams, R.J., Iglesias-Fernandez, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J.
Deposit date:2013-10-30
Release date:2014-04-02
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
Angew.Chem.Int.Ed.Engl., 53, 2014
4RE2
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DIFFERENT TRANSITION STATE CONFORMATIONS FOR THE HYDROLYSIS OF BETA-MANNOSIDES AND BETA-GLUCOSIDES IN THE RICE OS7BGLU26 FAMILY GH1 BETA-MANNOSIDASE/BETA-GLUCOSIDASE
Descriptor:Beta-mannosidase/beta-glucosidase, (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Tankrathok, A., Iglesias-Fernandez, J., Williams, R.J., Hakki, Z., Robinson, R.C., Hrmova, M., Rovira, C., Williams, S.J., Ketudat Cairns, J.R.
Deposit date:2014-09-21
Release date:2015-09-16
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015
4RE3
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DIFFERENT TRANSITION STATE CONFORMATIONS FOR THE HYDROLYSIS OF BETA-MANNOSIDES AND BETA-GLUCOSIDES IN THE RICE OS7BGLU26 FAMILY GH1 BETA-MANNOSIDASE/BETA-GLUCOSIDASE
Descriptor:Beta-mannosidase/beta-glucosidase, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Tankrathok, A., Iglesias-Fernandez, J., Williams, R.J., Hakki, Z., Robinson, R.C., Hrmova, M., Rovira, C., Williams, S.J., Ketudat Cairns, J.R.
Deposit date:2014-09-21
Release date:2015-09-16
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015
4RE4
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DIFFERENT TRANSITION STATE CONFORMATIONS FOR THE HYDROLYSIS OF BETA-MANNOSIDES AND BETA-GLUCOSIDES IN THE RICE OS7BGLU26 FAMILY GH1 BETA-MANNOSIDASE/BETA-GLUCOSIDASE
Descriptor:Beta-mannosidase/beta-glucosidase, 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, GLYCEROL, ...
Authors:Tankrathok, A., Iglesias-Fernandez, J., Williams, R.J., Hakki, Z., Robinson, R.C., Hrmova, M., Rovira, C., Williams, S.J., Ketudat Cairns, J.R.
Deposit date:2014-09-21
Release date:2015-09-16
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015
4BJM
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CRYSTAL STRUCTURE OF THE FLAX-RUST EFFECTOR AVRM
Descriptor:AVRM, CHLORIDE ION
Authors:Ve, T., Williams, S.J., Kobe, B.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2013-11-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structures of the Flax-Rust Effector Avrm Reveal Insights Into the Molecular Basis of Plant-Cell Entry and Effector-Triggered Immunity
Proc.Natl.Acad.Sci.USA, 110, 2013