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1YB5
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CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN WITH BOUND NADP
Descriptor:Quinone oxidoreductase, ACETATE ION, CHLORIDE ION, ...
Authors:Debreczeni, J., Berridge, G., Kavanagh, K., Colbrook, S., Bray, J., Williams, L., Oppermann, U., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., von Delft, F., Structural Genomics Consortium (SGC)
Deposit date:2004-12-20
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of human Zeta-Crystallin at 1.85A
To be Published
1ZSX
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CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNIT (KCNAB2)
Descriptor:Voltage-gated potassium channel beta-2 subunit, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wennerstrand, P., Johannsson, I., Ugochukwu, E., Kavanagh, K., Edwards, A., Arrowsmith, C., Williams, L., Sundstrom, M., Guo, K., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-05-25
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)
To be Published
1BJU
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BETA-TRYPSIN COMPLEXED WITH ACPU
Descriptor:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Presnell, S., Patil, G., Mura, C., Jude, K., Conley, J., Kam, C., Bertrand, J., Powers, J., Williams, L.
Deposit date:1998-06-29
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
1BJV
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BETA-TRYPSIN COMPLEXED WITH APPU
Descriptor:BETA-TRYPSIN, CALCIUM ION, SULFATE ION, ...
Authors:Presnell, S., Patil, G., Mura, C., Jude, K., Conley, J., Kam, C., Bertrand, J., Powers, J., Williams, L.
Deposit date:1998-06-29
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
1MAX
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BETA-TRYPSIN PHOSPHONATE INHIBITED
Descriptor:BETA-TRYPSIN, CALCIUM ION, [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Authors:Bertrand, J., Oleksyszyn, J., Kam, C., Boduszek, B., Presnell, S., Plaskon, R., Suddath, F., Powers, J., Williams, L.
Deposit date:1996-02-06
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Biochemistry, 35, 1996
1MAY
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BETA-TRYPSIN PHOSPHONATE INHIBITED
Descriptor:BETA-TRYPSIN, CALCIUM ION, [N-(BENZYLOXYCARBONYL)AMINO](4-AMIDINOPHENYL)METHANE-PHOSPHONATE
Authors:Bertrand, J., Oleksyszyn, J., Kam, C., Boduszek, B., Presnell, S., Plaskon, R., Suddath, F., Powers, J., Williams, L.
Deposit date:1996-02-06
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
Biochemistry, 35, 1996
4MLE
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HUMAN GLUCOKINASE IN COMPLEX WITH NOVEL AMINO THIAZOLE ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
4MLH
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HUMAN GLUCOKINASE IN COMPLEX WITH A NOVEL AMINO THIAZOLE ALLOSTERIC ACTIVATOR
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine
Authors:Voegtli, W.C.
Deposit date:2013-09-06
Release date:2013-09-25
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56, 2013
3HK5
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CRYSTAL STRUCTURE OF URONATE ISOMERASE FROM BACILLUS HALODURANS COMPLEXED WITH ZINC AND D-ARABINARATE
Descriptor:Uronate isomerase, D-arabinaric acid, CARBONATE ION, ...
Authors:Fedorov, A.A., Fedorov, E.V., Nguyen, T.T., Raushel, F.M., Almo, S.C.
Deposit date:2009-05-22
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry, 48, 2009
3HK7
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CRYSTAL STRUCTURE OF URONATE ISOMERASE FROM BACILLUS HALODURANS COMPLEXED WITH ZINC AND D-ARABINARATE, MONOCLINIC CRYSTAL FORM
Descriptor:Uronate isomerase, D-arabinaric acid, CARBONATE ION, ...
Authors:Fedorov, A.A., Fedorov, E.V., Nguyen, T.T., Raushel, F.M., Almo, S.C.
Deposit date:2009-05-22
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry, 48, 2009
3HK8
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CRYSTAL STRUCTURE OF URONATE ISOMERASE FROM BACILLUS HALODURANS COMPLEXED WITH ZINC AND D-ARABINOHYDROXAMATE
Descriptor:Uronate isomerase, D-arabinohydroxamic acid, CARBONATE ION, ...
Authors:Fedorov, A.A., Fedorov, E.V., Nguyen, T.T., Raushel, F.M., Almo, S.C.
Deposit date:2009-05-22
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry, 48, 2009
3HK9
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CRYSTAL STRUCTURE OF URONATE ISOMERASE FROM BACILLUS HALODURANS COMPLEXED WITH ZINC AND D-GLUCURONATE
Descriptor:Uronate isomerase, D-glucuronic acid, CARBONATE ION, ...
Authors:Fedorov, A.A., Fedorov, E.V., Nguyen, T.T., Raushel, F.M., Almo, S.C.
Deposit date:2009-05-22
Release date:2009-08-25
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry, 48, 2009
3HKA
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CRYSTAL STRUCTURE OF URONATE ISOMERASE FROM BACILLUS HALODURANS COMPLEXED WITH ZINC AND D-FRUCTURONATE
Descriptor:Uronate isomerase, D-fructuronic acid, CARBONATE ION, ...
Authors:Fedorov, A.A., Fedorov, E.V., Nguyen, T.T., Raushel, F.M., Almo, S.C.
Deposit date:2009-05-22
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry, 48, 2009
4RCH
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DISCOVERY OF 2-PYRIDYL UREAS AS GLUCOKINASE ACTIVATORS
Descriptor:Glucokinase, ALPHA-D-GLUCOSE, 1-{3-[(2-ethylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}-3-methylurea
Authors:Voegtli, W., Vigers, G.P.A.
Deposit date:2014-09-16
Release date:2014-10-08
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of 2-pyridylureas as glucokinase activators.
J.Med.Chem., 57, 2014