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6FPN
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BU of 6fpn by Molmil
Lytic transglycosylase in action
Descriptor: Putative soluble lytic murein transglycosylase, SULFATE ION
Authors:Williams, A.H, Hoauz, A, Boneca, I.G.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
6H5F
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BU of 6h5f by Molmil
LtgA disordered Helix
Descriptor: Putative soluble lytic murein transglycosylase
Authors:Williams, A.H.
Deposit date:2018-07-24
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation inNeisseria meningitidis.
Elife, 9, 2020
5MPQ
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BU of 5mpq by Molmil
Bulgecin A: The key to a broad-spectrum inhibitor that targets lytic transglycosylases
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-O-(4-O-SULFONYL-N-ACETYLGLUCOSAMININYL)-5-METHYLHYDROXY-L-PROLINE-TAURINE, MAGNESIUM ION, ...
Authors:Williams, A.H.
Deposit date:2016-12-17
Release date:2017-03-29
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Antibiotics, 6, 2017
4K7J
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BU of 4k7j by Molmil
Peptidoglycan O-acetylesterase in action, 5 min
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H, Gomperts Boneca, I.
Deposit date:2013-04-17
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
5O2N
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BU of 5o2n by Molmil
Lytic transglycosylase in action
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CITRATE ANION, ...
Authors:Williams, A.H, Hoauz, A, Boneca, I.G.
Deposit date:2017-05-22
Release date:2018-03-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.513 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O29
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BU of 5o29 by Molmil
Lytic transglycosylase in action
Descriptor: Transglycosylase
Authors:Williams, A.H, Hoauz, A, Boneca, I.G.
Deposit date:2017-05-19
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.3785 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O1J
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BU of 5o1j by Molmil
Lytic transglycosylase in action
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-1,6-anhydro-N-acetyl-beta-D-glucopyranosamine, Putative soluble lytic murein transglycosylase, ZINC ION
Authors:Williams, A.H, Rateau, L, Hoauz, A, Boneca, I.G.
Deposit date:2017-05-18
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O2O
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BU of 5o2o by Molmil
Lytic transglycosylase in action
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transglycosylase
Authors:Williams, A.H, Hoauz, A, Boneca, I.G.
Deposit date:2017-05-22
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Lytic transglycosylase in action
To Be Published
5O24
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BU of 5o24 by Molmil
Lytic transglycosylase in action
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Transglycosylase
Authors:Williams, A.H, Hoauz, A, Boneca, I.G.
Deposit date:2017-05-19
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.429 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
6QCM
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BU of 6qcm by Molmil
Cryo em structure of the Listeria stressosome
Descriptor: RsbR protein, RsbR protein,RsbR protein, RsbS protein
Authors:Williams, A.H, Redzej, A, Waksman, G, Cossart, P.
Deposit date:2018-12-28
Release date:2019-08-21
Method:ELECTRON MICROSCOPY (4.21 Å)
Cite:The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.
Nat Commun, 10, 2019
4K9S
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BU of 4k9s by Molmil
Peptidoglycan O-acetylesterase in action, setmet
Descriptor: GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H, Gompert Boneca, I.
Deposit date:2013-04-21
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.334 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
4K40
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BU of 4k40 by Molmil
Peptidoglycan O-acetylesterase in action, 0 min
Descriptor: GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H, Gompert Boneca, I.
Deposit date:2013-04-11
Release date:2014-09-03
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.634 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
4K3U
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BU of 4k3u by Molmil
Peptidoglycan O-acetylesterase in action, 30 min
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H, Gomperts Boneca, I.
Deposit date:2013-04-11
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.158 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
2AQ9
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BU of 2aq9 by Molmil
Structure of E. coli LpxA with a bound peptide that is competitive with acyl-ACP
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, DIMETHYL SULFOXIDE, PHOSPHATE ION, ...
Authors:Williams, A.H, Immormino, R.M, Gewirth, D.T, Raetz, C.R.
Deposit date:2005-08-17
Release date:2006-06-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2QIV
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BU of 2qiv by Molmil
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Descriptor: UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H, Raetz, C.R.H.
Deposit date:2007-07-05
Release date:2007-10-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QIA
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BU of 2qia by Molmil
Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine Acyltransferase
Descriptor: UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H, Raetz, C.R.H.
Deposit date:2007-07-03
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
6HY2
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BU of 6hy2 by Molmil
Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, TRP-MET-LEU-ASP-PRO-ILE-ALA-GLY-LYS-TRP-SER-ARG
Authors:Williams, A.H, Dangkulwanich, M.
Deposit date:2018-10-19
Release date:2019-01-23
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase.
Sci Rep, 9, 2019
3I3X
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BU of 3i3x by Molmil
Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, uridine-5'-diphosphate-3-N-(R-3-hydroxylauroyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H.
Deposit date:2009-07-01
Release date:2009-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
3I3A
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BU of 3i3a by Molmil
Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate
Authors:Williams, A.H.
Deposit date:2009-06-30
Release date:2009-09-01
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
3T7E
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BU of 3t7e by Molmil
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway
Descriptor: Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION
Authors:Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7H
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BU of 3t7h by Molmil
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway
Descriptor: Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7G
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BU of 3t7g by Molmil
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway
Descriptor: Autophagy-related protein 3, Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7F
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BU of 3t7f by Molmil
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway
Descriptor: Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M, Tait, S.W, Kaiser, S.E, Williams, A.H, Deng, A, Nourse, A, Hammel, M, Kurinov, I, Rock, C.O, Green, D.R, Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3HSQ
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BU of 3hsq by Molmil
Structural Basis for the Sugar Nucleotide and Acyl Chain Selectivity of Leptospira interrogans LpxA
Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Authors:Robins, L.I, Williams, A.H, Raetz, C.R.
Deposit date:2009-06-10
Release date:2009-09-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
7PCR
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BU of 7pcr by Molmil
Helicobacter pylori RNase J
Descriptor: Ribonuclease J
Authors:Luisi, B.F, Pei, X.Y.
Deposit date:2021-08-03
Release date:2022-05-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Acetylation regulates the oligomerization state and activity of RNase J, the Helicobacter pylori major ribonuclease.
Nat Commun, 14, 2023

 

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