Author results

2AQ9
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STRUCTURE OF E. COLI LPXA WITH A BOUND PEPTIDE THAT IS COMPETITIVE WITH ACYL-ACP
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, peptide inhibitor, PHOSPHATE ION, ...
Authors:Williams, A.H., Immormino, R.M., Gewirth, D.T., Raetz, C.R.
Deposit date:2005-08-17
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial pentadecapeptide.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2QIA
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STRUCTURAL BASIS FOR THE ACYL CHAIN SELECTIVITY AND MECHANISM OF UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H., Raetz, C.R.H.
Deposit date:2007-07-03
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
2QIV
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STRUCTURAL BASIS FOR THE ACYL CHAIN SELECTIVITY AND MECHANISM OF UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:UDP-N-acetylglucosamine acyltransferase, uridine-5'-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H., Raetz, C.R.H.
Deposit date:2007-07-05
Release date:2007-10-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase
Proc.Natl.Acad.Sci.Usa, 104, 2007
4K3U
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PEPTIDOGLYCAN O-ACETYLESTERASE IN ACTION, 30 MIN
Descriptor:GDSL-like Lipase/Acylhydrolase family protein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Williams, A.H., Gomperts Boneca, I.
Deposit date:2013-04-11
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.158 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
4K40
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PEPTIDOGLYCAN O-ACETYLESTERASE IN ACTION, 0 MIN
Descriptor:GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H., Gompert Boneca, I.
Deposit date:2013-04-11
Release date:2014-09-03
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.634 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
4K7J
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PEPTIDOGLYCAN O-ACETYLESTERASE IN ACTION, 5 MIN
Descriptor:GDSL-like Lipase/Acylhydrolase family protein, ACETATE ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Williams, A.H., Gomperts Boneca, I.
Deposit date:2013-04-17
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
4K9S
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PEPTIDOGLYCAN O-ACETYLESTERASE IN ACTION, SETMET
Descriptor:GDSL-like Lipase/Acylhydrolase family protein
Authors:Williams, A.H., Gompert Boneca, I.
Deposit date:2013-04-21
Release date:2014-09-03
Last modified:2014-10-22
Method:X-RAY DIFFRACTION (2.334 Å)
Cite:Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
5MPQ
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BULGECIN A: THE KEY TO A BROAD-SPECTRUM INHIBITOR THAT TARGETS LYTIC TRANSGLYCOSYLASES
Descriptor:Transglycosylase, 4-O-(4-O-SULFONYL-N-ACETYLGLUCOSAMININYL)-5-METHYLHYDROXY-L-PROLINE-TAURINE, MAGNESIUM ION, ...
Authors:Williams, A.H.
Deposit date:2016-12-17
Release date:2017-03-29
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.
Antibiotics, 6, 2017
5O1J
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Putative soluble lytic murein transglycosylase, N-ACETYL-D-GLUCOSAMINE, N-[(1R,2S,3R,4R,5R)-2,3-bis(oxidanyl)-6,8-dioxabicyclo[3.2.1]octan-4-yl]ethanamide, ...
Authors:Williams, A.H., Rateau, L., Hoauz, A., Boneca, I.G.
Deposit date:2017-05-18
Release date:2018-03-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O24
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Transglycosylase, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Williams, A.H., Hoauz, A., Boneca, I.G.
Deposit date:2017-05-19
Release date:2018-03-14
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.429 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O29
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Transglycosylase
Authors:Williams, A.H., Hoauz, A., Boneca, I.G.
Deposit date:2017-05-19
Release date:2018-03-14
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.3785 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O2N
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Transglycosylase, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Williams, A.H., Hoauz, A., Boneca, I.G.
Deposit date:2017-05-22
Release date:2018-03-14
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.513 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
5O2O
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Transglycosylase, N-ACETYL-D-GLUCOSAMINE, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID
Authors:Williams, A.H., Hoauz, A., Boneca, I.G.
Deposit date:2017-05-22
Release date:2018-06-13
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Lytic transglycosylase in action
To Be Published
6FPN
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LYTIC TRANSGLYCOSYLASE IN ACTION
Descriptor:Putative soluble lytic murein transglycosylase, SULFATE ION
Authors:Williams, A.H., Hoauz, A., Boneca, I.G.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
6H5F
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LTGA DISORDERED HELIX
Descriptor:Putative soluble lytic murein transglycosylase
Authors:Williams, A.H.
Deposit date:2018-07-24
Release date:2019-08-28
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:LtgA disordered Helix
To Be Published
6QCM
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CRYO EM STRUCTURE OF THE LISTERIA STRESSOSOME
Descriptor:RsbR protein, RsbS protein, RsbR protein,RsbR protein
Authors:Williams, A.H., Redzej, A., Waksman, G., Cossart, P.
Deposit date:2018-12-28
Release date:2019-08-21
Method:ELECTRON MICROSCOPY (4.21 Å)
Cite:The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.
Nat Commun, 10, 2019
3I3A
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STRUCTURAL BASIS FOR THE SUGAR NUCLEOTIDE AND ACYL CHAIN SELECTIVITY OF LEPTOSPIRA INTERROGANS LPXA
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate
Authors:Williams, A.H.
Deposit date:2009-06-30
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
3I3X
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STRUCTURAL BASIS FOR THE SUGAR NUCLEOTIDE AND ACYL CHAIN SELECTIVITY OF LEPTOSPIRA INTERROGANS LPXA
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, uridine-5'-diphosphate-3-N-(R-3-hydroxylauroyl)-N-acetyl-D-glucosamine
Authors:Williams, A.H.
Deposit date:2009-07-01
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
6HY2
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STRUCTURE GUIDED DESIGN OF AN ANTIBACTERIAL PEPTIDE THAT TARGETS UDP-N-ACETYLGLUCOSAMINE ACYLTRANSFERASE
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, TRP-MET-LEU-ASP-PRO-ILE-ALA-GLY-LYS-TRP-SER-ARG
Authors:Williams, A.H., Dangkulwanich, M.
Deposit date:2018-10-19
Release date:2019-01-23
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase.
Sci Rep, 9, 2019
3HSQ
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STRUCTURAL BASIS FOR THE SUGAR NUCLEOTIDE AND ACYL CHAIN SELECTIVITY OF LEPTOSPIRA INTERROGANS LPXA
Descriptor:Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Authors:Robins, L.I., Williams, A.H., Raetz, C.R.
Deposit date:2009-06-10
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA.
Biochemistry, 48, 2009
3T7E
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, ZINC ION
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7F
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7G
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7, Autophagy-related protein 3
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011
3T7H
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ATG8 TRANSFER FROM ATG7 TO ATG3: A DISTINCTIVE E1-E2 ARCHITECTURE AND MECHANISM IN THE AUTOPHAGY PATHWAY
Descriptor:Ubiquitin-like modifier-activating enzyme ATG7
Authors:Taherbhoy, A.M., Tait, S.W., Kaiser, S.E., Williams, A.H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C.O., Green, D.R., Schulman, B.A.
Deposit date:2011-07-30
Release date:2011-11-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.
Mol.Cell, 44, 2011