Author results

6TAA
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STRUCTURE AND MOLECULAR MODEL REFINEMENT OF ASPERGILLUS ORYZAE (TAKA) ALPHA-AMYLASE: AN APPLICATION OF THE SIMULATED-ANNEALING METHOD
Descriptor:ALPHA-AMYLASE, CALCIUM ION
Authors:Swift, H.J., Brady, L., Derewenda, Z.S., Dodson, E.J., Turkenburg, J.P., Wilkinson, A.J.
Deposit date:1992-08-21
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and molecular model refinement of Aspergillus oryzae (TAKA) alpha-amylase: an application of the simulated-annealing method.
Acta Crystallogr.,Sect.B, 47, 1991
5UCG
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STRUCTURE OF THE PP2C PHOSPHATASE DOMAIN AND A FRAGMENT OF THE REGULATORY DOMAIN OF THE CELL FATE DETERMINANT SPOIIE FROM BACILLUS SUBTILIS
Descriptor:Stage II sporulation protein E
Authors:Bradshaw, N., Levdikov, V., Zimanyi, C., Gaudet, R., Wilkinson, A., Losick, R.
Deposit date:2016-12-22
Release date:2017-05-31
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.906 Å)
Cite:A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.
Elife, 6, 2017
5OCP
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THE PERIPLASMIC BINDING PROTEIN COMPONENT OF THE ARABINOSE ABC TRANSPORTER FROM SHEWANELLA SP. ANA-3 BOUND TO ALPHA AND BETA-L-ARABINOFURANOSE
Descriptor:Periplasmic binding protein/LacI transcriptional regulator, GLYCEROL, ALPHA-L-ARABINOFURANOSE, ...
Authors:Herman, R.
Deposit date:2017-07-03
Release date:2018-08-01
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:CHARACTERISATION OF A FURANOSE SPECIFIC ABC TRANSPORTER ESSENTIAL FOR ARABINOSE UTILISATION FROM THE LIGNOCELLULOSE DEGRADING BACTERIUM SHEWANELLA SP. ANA-3
To Be Published
5O6J
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HUMAN NMT1 IN COMPLEX WITH MYRISTOYL-COA AND INHIBITOR IMP-1031
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, PHOSPHATE ION, ...
Authors:Brannigan, J.A., Wilkinson, A.J.
Deposit date:2017-06-06
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Nat Chem, 10, 2018
5O6H
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HUMAN NMT1 IN COMPLEX WITH MYRISTOYL-COA AND INHIBITOR IMP-917
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, PHOSPHATE ION, ...
Authors:Brannigan, J.A., Wilkinson, A.J.
Deposit date:2017-06-06
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Nat Chem, 10, 2018
5O4V
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P.VIVAX NMT WITH AMINOMETHYLINDAZOLE AND QUINOLINE INHIBITORS BOUND
Descriptor:Glycylpeptide N-tetradecanoyltransferase, 2-oxopentadecyl-CoA, 1-[5-(4-fluoranyl-2-methyl-phenyl)-1~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, ...
Authors:Brannigan, J.A., Wilkinson, A.J.
Deposit date:2017-05-31
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Nat Chem, 10, 2018
5O48
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P.VIVAX NMT WITH AN AMINOMETHYLINDAZOLE INHIBITOR BOUND
Descriptor:Glycylpeptide N-tetradecanoyltransferase, 2-oxopentadecyl-CoA, 1-[5-(4-fluoranyl-2-methyl-phenyl)-1~{H}-indazol-3-yl]-~{N},~{N}-dimethyl-methanamine, ...
Authors:Brannigan, J.A., Wilkinson, A.J.
Deposit date:2017-05-26
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Nat Chem, 10, 2018
5N0L
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THE STRUCTURE OF THE COFACTOR BINDING GAF DOMAIN OF THE NUTRIENT SENSOR CODY FROM CLOSTRIDIUM DIFFICILE
Descriptor:GTP-sensing transcriptional pleiotropic repressor CodY, ISOLEUCINE
Authors:Levdikov, V.M., Blagova, E.V., Wilkinson, A.J., Sonenshein, A.L.
Deposit date:2017-02-03
Release date:2018-02-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Impact of CodY protein on metabolism, sporulation and virulence in Clostridioides difficile ribotype 027
To Be Published
5MU6
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HUMAN N-MYRISTOYLTRANSFERASE (NMT1) WITH MYRISTOYL-COA AND IMP-1088 INHIBITOR BOUND
Descriptor:Glycylpeptide N-tetradecanoyltransferase 1, TETRADECANOYL-COA, MAGNESIUM ION, ...
Authors:Perez-Dorado, I., Bell, A.S., Tate, E.W.
Deposit date:2017-01-12
Release date:2018-02-14
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.
Nat Chem, 10, 2018
5MQH
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STRUCTURE OF THE PHOSPHATASE DOMAIN OF THE CELL FATE DETERMINANT SPOIIE FROM BACILLUS SUBTILIS IN A CRYSTAL FORM WITHOUT DOMAIN SWAPPING
Descriptor:Serine phosphatase
Authors:Levdikov, V.M., Wilkinson, A.J., Blagova, E.V.
Deposit date:2016-12-20
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.
Elife, 6, 2017
5LOO
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STRUCTURE OF FULL LENGTH UNLIGANDED CODY FROM BACILLUS SUBTILIS
Descriptor:GTP-sensing transcriptional pleiotropic repressor CodY
Authors:Wilkinson, A.J., Levdikov, V.M., Blagova, E.V.
Deposit date:2016-08-09
Release date:2017-01-11
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.
J. Biol. Chem., 292, 2017
5LOJ
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STRUCTURE OF FULL LENGTH UNLIGANDED CODY FROM BACILLUS SUBTILIS
Descriptor:GTP-sensing transcriptional pleiotropic repressor CodY
Authors:Wilkinson, A.J., Levdikov, V.M., Blagova, E.V.
Deposit date:2016-08-09
Release date:2017-01-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.
J. Biol. Chem., 292, 2017
5LOE
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STRUCTURE OF FULL LENGTH CODY FROM BACILLUS SUBTILIS IN COMPLEX WITH ILE
Descriptor:GTP-sensing transcriptional pleiotropic repressor CodY, ISOLEUCINE
Authors:Wilkinson, A.J., Levdikov, V.M., Blagova, E.V.
Deposit date:2016-08-09
Release date:2017-01-11
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.
J. Biol. Chem., 292, 2017
5LNH
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STRUCTURE OF FULL LENGTH UNLIGANDED CODY FROM BACILLUS SUBTILIS
Descriptor:GTP-sensing transcriptional pleiotropic repressor CodY, SULFATE ION
Authors:Wilkinson, A.J., Levdikov, V.M., Blagova, E.V.
Deposit date:2016-08-04
Release date:2017-01-11
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the Branched-chain Amino Acid and GTP-sensing Global Regulator, CodY, from Bacillus subtilis.
J. Biol. Chem., 292, 2017
5G22
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A QUINOLINE INHIBITOR (COMPOUND 26)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, ETHYL 4-[(2-CYANOETHYL)SULFANYL]-6-{[6-(PIPERAZIN-1-YL), ...
Authors:Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.
Deposit date:2016-04-06
Release date:2017-02-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017
5G21
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A QUINOLINE INHIBITOR (COMPOUND 26).
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, TETRADECANOYL-COA, ...
Authors:Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.
Deposit date:2016-04-06
Release date:2017-02-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017
5G20
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A QUINOLINE INHIBITOR (COMPOUND 19).
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, TETRADECANOYL-COA, ...
Authors:Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.
Deposit date:2016-04-06
Release date:2017-02-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017
5G1Z
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A QUINOLINE INHIBITOR (COMPOUND 1)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, ethyl 4-(2-cyanoethylsulfanyl)-6-methoxy-quinoline-3-carboxylate, ...
Authors:Goncalves, V., Brannigan, J.A., Laporte, A., Bell, A.S., Roberts, S.M., Wilkinson, A.J., Leatherbarrow, R.J., Tate, E.W.
Deposit date:2016-04-06
Release date:2017-02-15
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.
Medchemcomm, 8, 2017
5DOL
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CRYSTAL STRUCTURE OF YABA AMINO-TERMINAL DOMAIN FROM BACILLUS SUBTILIS
Descriptor:Initiation-control protein YabA
Authors:Cherrier, M.V., Bazin, A., Jameson, K.H., Wilkinson, A.J., Noirot-Gros, M.F., Terradot, L.
Deposit date:2015-09-11
Release date:2016-01-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners.
Nucleic Acids Res., 44, 2016
5AEO
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VIRULENCE-ASSOCIATED PROTEIN VAPG FROM THE INTRACELLULAR PATHOGEN RHODOCOCCUS EQUI
Descriptor:R. EQUI VAPG PROTEIN, POTASSIUM ION
Authors:Okoko, T., Blagova, E.V., Whittingham, J.L., Dover, L.G., Wilkinson, A.J.
Deposit date:2015-01-07
Release date:2015-03-25
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Characterisation of the Virulence-Associated Protein Vapg from the Horse Pathogen Rhodococcus Equi.
Vet.Microbiol., 179, 2015
5A28
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A CHLOROPHENYL 1,3,4-OXADIAZOLE INHIBITOR.
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 4-(4-chloro-2-{5-[(trimethyl-1H-pyrazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl}phenoxy)piperidine, ...
Authors:Rackham, M.D., Yu, Z., Brannigan, J.A., Heal, W.P., Paape, D., Barker, K.V., Wilkinson, A.J., Smith, D.F., Tate, E.W., Leatherbarrow, R.J.
Deposit date:2015-05-15
Release date:2016-03-23
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
5A27
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LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A CHLOROPHENYL 1,2,4-OXADIAZOLE INHIBITOR.
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA, 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
Authors:Rackham, M.D., Yu, Z., Brannigan, J.A., Heal, W.P., Paape, D., Barker, K.V., Wilkinson, A.J., Smith, D.F., Tate, E.W., Leatherbarrow, R.J.
Deposit date:2015-05-15
Release date:2016-03-23
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
4UFX
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 19)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-pyridine-3-carboxamide, 2-oxopentadecyl-CoA, ...
Authors:Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
Deposit date:2015-03-19
Release date:2016-02-03
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
4UFW
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 22)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, 4-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
Authors:Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
Deposit date:2015-03-19
Release date:2016-02-03
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015
4UFV
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PLASMODIUM VIVAX N-MYRISTOYLTRANSFERASE IN COMPLEX WITH A PYRIDYL INHIBITOR (COMPOUND 18)
Descriptor:GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2-oxopentadecyl-CoA, N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, ...
Authors:Yu, Z., Brannigan, J.A., Rangachari, K., Heal, W.P., Wilkinson, A.J., Holder, A.A., Tate, E.W., Leatherbarrow, R.J.
Deposit date:2015-03-19
Release date:2016-02-03
Last modified:2016-04-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of Pyridyl-Based Inhibitors of Plasmodium Falciparum N-Myristoyltransferase
Medchemcomm, 6, 2015