6CM2
 
 | | SAMHD1 HD domain bound to decitabine triphosphate | | Descriptor: | 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Oellerich, T, Schneider, C, Thomas, D, Knecht, K.M, Buzovetsky, O, Kaderali, L, Schliemann, C, Bohnenberger, H, Angenendt, L, Hartmann, W, Wardelmann, E, Rothenburger, T, Mohr, S, Scheich, S, Comoglio, F, Wilke, A, Strobel, P, Serve, H, Michaelis, M, Ferreiros, N, Geisslinger, G, Xiong, Y, Keppler, O.T, Cinatl, J. | | Deposit date: | 2018-03-02 | | Release date: | 2019-06-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Nat Commun, 10, 2019
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1SK7
 | | Structural Basis for Novel Delta-Regioselective Heme Oxygenation in the Opportunistic Pathogen Pseudomonas aeruginosa | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, hypothetical protein pa-HO | | Authors: | Friedman, J, Lad, L, Li, H, Wilks, A, Poulos, T.L. | | Deposit date: | 2004-03-04 | | Release date: | 2004-06-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural basis for novel delta-regioselective heme oxygenation in the opportunistic pathogen Pseudomonas aeruginosa
Biochemistry, 43, 2004
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6U87
 | | Pseudomonas aeruginosa HasA mutant - Y75H | | Descriptor: | HasAp, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Brimberry, M, Lanzilotta, W, Wilks, A, Dent, A. | | Deposit date: | 2019-09-04 | | Release date: | 2020-09-09 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa .
Biochemistry, 60, 2021
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1J77
 | | Crystal Structure of Gram-negative Bacterial Heme Oxygenase Complexed with Heme | | Descriptor: | HemO, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Schuller, D.J, Zhu, W, Stojiljkovic, I, Wilks, A, Poulos, T.L. | | Deposit date: | 2001-05-15 | | Release date: | 2001-05-30 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of heme oxygenase from the gram-negative pathogen Neisseria meningitidis and a comparison with mammalian heme oxygenase-1.
Biochemistry, 40, 2001
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1P3T
 | | Crystal Structures of the NO-and CO-Bound Heme Oxygenase From Neisseria Meningitidis: Implications for Oxygen Activation | | Descriptor: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Friedman, J, Lad, L, Deshmukh, R, Li, H, Wilks, A, Poulos, T.L. | | Deposit date: | 2003-04-18 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation
J.Biol.Chem., 278, 2003
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1P3V
 | | Crystal Structures of the NO-and CO-Bound Heme Oxygenase From Neisseria Meningitidis: Implications for Oxygen Activation | | Descriptor: | CARBON MONOXIDE, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Friedman, J, Lad, L, Deshmukh, R, Li, H, Wilks, A, Poulos, T.L. | | Deposit date: | 2003-04-18 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation
J.Biol.Chem., 278, 2003
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1P3U
 | | Crystal Structures of the NO-and CO-Bound Heme Oxygenase From Neisseria Meningitidis: Implications for Oxygen Activation | | Descriptor: | Heme oxygenase 1, NITRIC OXIDE, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Friedman, J, Lad, L, Deshmukh, R, Li, H, Wilks, A, Poulos, T.L. | | Deposit date: | 2003-04-18 | | Release date: | 2003-12-09 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structures of the NO- and CO-bound heme oxygenase from Neisseriae meningitidis. Implications for O2 activation
J.Biol.Chem., 278, 2003
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6TGW
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1N45
 | | X-RAY CRYSTAL STRUCTURE OF HUMAN HEME OXYGENASE-1 (HO-1) IN COMPLEX WITH ITS SUBSTRATE HEME | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, heme oxygenase 1 | | Authors: | Schuller, D.J, Wilks, A, Ortiz de Montellano, P.R, Poulos, T.L. | | Deposit date: | 2002-10-30 | | Release date: | 2002-11-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1.
J. Biol. Chem., 278, 2003
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1N3U
 | | Crystal structure of human heme oxygenase 1 (HO-1) in complex with its substrate heme, crystal form B | | Descriptor: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, heme oxygenase 1 | | Authors: | Lad, L, Schuller, D.J, Friedman, J.P, Li, H, Ortiz de Montellano, P.R, Poulos, T.L. | | Deposit date: | 2002-10-29 | | Release date: | 2002-11-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1
J.Biol.Chem., 278, 2003
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2R7A
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2R79
 | | Crystal Structure of a Periplasmic Heme Binding Protein from Pseudomonas aeruginosa | | Descriptor: | GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, Periplasmic binding protein, ... | | Authors: | Ho, W.W, Li, H, Poulos, T.L. | | Deposit date: | 2007-09-07 | | Release date: | 2007-10-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Holo- and apo-bound structures of bacterial periplasmic heme-binding proteins.
J.Biol.Chem., 282, 2007
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2RG7
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4IMH
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6URB
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