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3GOD
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BU of 3god by Molmil
Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated antiviral defense
Descriptor: CALCIUM ION, Cas1, MANGANESE (II) ION, ...
Authors:Wiedenheft, B.
Deposit date:2009-03-18
Release date:2009-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense.
Structure, 17, 2009
8FLJ
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BU of 8flj by Molmil
Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA
Descriptor: CRISPR leader and repeat, anti-sense strand of DNA, CRISPR leader, ...
Authors:Santiago-Frangos, A, Henriques, W.S, Wiegand, T, Gauvin, C, Buyukyoruk, M, Neselu, K, Eng, E.T, Lander, G.C, Wiedenheft, B.
Deposit date:2022-12-21
Release date:2023-09-06
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays.
Nat.Struct.Mol.Biol., 30, 2023
4TVX
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BU of 4tvx by Molmil
Crystal structure of the E. coli CRISPR RNA-guided surveillance complex, Cascade
Descriptor: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ...
Authors:Jackson, R.N, Golden, S.M, Carter, J, Wiedenheft, B.
Deposit date:2014-06-28
Release date:2014-08-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.
Science, 345, 2014
6NE0
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BU of 6ne0 by Molmil
Structure of double-stranded target DNA engaged Csy complex from Pseudomonas aeruginosa (PA-14)
Descriptor: CRISPR RNA (60-MER), CRISPR target DNA (44-MER), CRISPR-associated endonuclease Cas6/Csy4, ...
Authors:Chowdhury, S, Rollins, M.F, Carter, J, Golden, S.M, Miettinen, H.M, Santiago-Frangos, A, Faith, D, Lawrence, M.C, Wiedenheft, B, Lander, G.C.
Deposit date:2018-12-15
Release date:2018-12-26
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry.
Mol. Cell, 74, 2019
2CLB
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BU of 2clb by Molmil
The structure of the DPS-like protein from Sulfolobus solfataricus reveals a bacterioferritin-like di-metal binding site within a Dps- like dodecameric assembly
Descriptor: DPS-LIKE PROTEIN, FE (III) ION, ZINC ION
Authors:Gauss, G.H, Benas, P, Wiedenheft, B, Young, M, Douglas, T, Lawrence, C.M.
Deposit date:2006-04-26
Release date:2006-07-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Dps-Like Protein from Sulfolobus Solfataricus Reveals a Bacterioferritin-Like Dimetal Binding Site within a Dps-Like Dodecameric Assembly.
Biochemistry, 45, 2006
5CD4
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BU of 5cd4 by Molmil
The Type IE CRISPR Cascade complex from E. coli, with two assemblies in the asymmetric unit arranged back-to-back
Descriptor: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ...
Authors:Jackson, R.N, Golden, S.M, Carter, J, Wiedenheft, B.
Deposit date:2015-07-03
Release date:2015-08-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.
Nucleic Acids Res., 43, 2015
5UZ9
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BU of 5uz9 by Molmil
Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex
Descriptor: Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ...
Authors:Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B.
Deposit date:2017-02-25
Release date:2017-04-26
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.
Cell, 169, 2017
1SKV
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BU of 1skv by Molmil
Crystal Structure of D-63 from Sulfolobus Spindle Virus 1
Descriptor: Hypothetical 7.5 kDa protein
Authors:Kraft, P, Kummel, D, Oeckinghaus, A, Gauss, G.H, Wiedenheft, B, Young, M, Lawrence, C.M.
Deposit date:2004-03-05
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of d-63 from sulfolobus spindle-shaped virus 1: surface properties of the dimeric four-helix bundle suggest an adaptor protein function
J.Virol., 78, 2004
4AN8
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BU of 4an8 by Molmil
Structure of Thermus thermophilus CasA (Cse1)
Descriptor: ACETATE ION, CSE1
Authors:Sashital, D.G, Wiedenheft, B, Doudna, J.A.
Deposit date:2012-03-16
Release date:2012-05-02
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System.
Mol.Cell, 46, 2012
1TBX
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BU of 1tbx by Molmil
Crystal structure of SSV1 F-93
Descriptor: Hypothetical 11.0 kDa protein
Authors:Kraft, P, Oeckinghaus, A, Kummel, D, Gauss, G.H, Wiedenheft, B, Young, M, Lawrence, C.M.
Deposit date:2004-05-20
Release date:2004-07-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein.
J.Virol., 78, 2004
6W1X
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BU of 6w1x by Molmil
Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex
Descriptor: CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ...
Authors:Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G.
Deposit date:2020-03-04
Release date:2020-05-13
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.
Nat Commun, 11, 2020
6WHI
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BU of 6whi by Molmil
Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9
Descriptor: CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ...
Authors:Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G.
Deposit date:2020-04-08
Release date:2020-05-13
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex.
Nat Commun, 11, 2020
5H9E
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BU of 5h9e by Molmil
Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target (32-nt spacer) at 3.20 angstrom resolution.
Descriptor: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ...
Authors:Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A.
Deposit date:2015-12-28
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Nature, 530, 2016
5H9F
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BU of 5h9f by Molmil
Crystal structure of E. coli Cascade bound to a PAM-containing dsDNA target at 2.45 angstrom resolution.
Descriptor: CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasC, ...
Authors:Hayes, R.P, Xiao, Y, Ding, F, van Erp, P.B.G, Rajashankar, K, Bailey, S, Wiedenheft, B, Ke, A.
Deposit date:2015-12-28
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.
Nature, 530, 2016
2XLI
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BU of 2xli by Molmil
Crystal structure of the Csy4-crRNA complex, monoclinic form
Descriptor: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE
Authors:Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A.
Deposit date:2010-07-20
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLJ
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BU of 2xlj by Molmil
Crystal structure of the Csy4-crRNA complex, hexagonal form
Descriptor: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE
Authors:Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A.
Deposit date:2010-07-20
Release date:2010-09-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLK
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BU of 2xlk by Molmil
Crystal structure of the Csy4-crRNA complex, orthorhombic form
Descriptor: 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3', CSY4 ENDORIBONUCLEASE
Authors:Haurwitz, R.E, Jinek, M, Wiedenheft, B, Zhou, K, Doudna, J.A.
Deposit date:2010-07-21
Release date:2010-09-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
7STW
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BU of 7stw by Molmil
Structure of DPSL (DNA Protection in Starved Cells - Like) from Pyrococcus furiosus
Descriptor: DNA protection during starvation protein, FE (III) ION, ZINC ION
Authors:Gauvin, C.C, Waghwani, H.K, Douglas, T, Lawrence, C.M.
Deposit date:2021-11-15
Release date:2021-12-01
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:Structure of DPSL (DNA Protection in Starved Cells - Like) from Pyrococcus furiosus
To be published
2VQC
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BU of 2vqc by Molmil
Structure of a DNA binding winged-helix protein, F-112, from Sulfolobus Spindle-shaped Virus 1.
Descriptor: HYPOTHETICAL 13.2 KDA PROTEIN
Authors:Menon, S.K, Kraft, P, Corn, G.J, Wiedenheft, B, Young, M.J, Lawrence, C.M.
Deposit date:2008-03-12
Release date:2008-05-06
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cysteine Usage in Sulfolobus Spindle-Shaped Virus 1 and Extension to Hyperthermophilic Viruses in General.
Virology, 376, 2008

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