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2WMF
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE TIGR4 (SP4GH98) IN ITS NATIVE FORM.
Descriptor:FUCOLECTIN-RELATED PROTEIN
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2WMG
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE TIGR4 (SP4GH98) IN COMPLEX WITH THE LEWISY PENTASACCHARIDE BLOOD GROUP ANTIGEN.
Descriptor:FUCOLECTIN-RELATED PROTEIN, ALPHA-L-FUCOSE, BETA-D-GALACTOSE, ...
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2WMH
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE TIGR4 IN COMPLEX WITH THE H- DISACCHARIDE BLOOD GROUP ANTIGEN.
Descriptor:FUCOLECTIN-RELATED PROTEIN, BETA-D-GALACTOSE, ALPHA-L-FUCOSE
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2WMI
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE SP3-BS71 IN COMPLEX WITH THE A-TRISACCHARIDE BLOOD GROUP ANTIGEN.
Descriptor:FUCOLECTIN-RELATED PROTEIN, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2WMJ
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE SP3-BS71 (SP3GH98) IN COMPLEX WITH THE B-TRISACCHARIDE BLOOD GROUP ANTIGEN.
Descriptor:FUCOLECTIN-RELATED PROTEIN, ALPHA D-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
2WMK
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CRYSTAL STRUCTURE OF THE CATALYTIC MODULE OF A FAMILY 98 GLYCOSIDE HYDROLASE FROM STREPTOCOCCUS PNEUMONIAE SP3-BS71 (SP3GH98) IN COMPLEX WITH THE A-LEWISY PENTASACCHARIDE BLOOD GROUP ANTIGEN.
Descriptor:FUCOLECTIN-RELATED PROTEIN, ALPHA-L-FUCOSE, BETA-D-GALACTOSE, ...
Authors:Higgins, M.A., Whitworth, G.E., El Warry, N., Randriantsoa, M., Samain, E., Burke, R.D., Vocadlo, D.J., Boraston, A.B.
Deposit date:2009-06-30
Release date:2009-07-14
Last modified:2012-11-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Differential Recognition and Hydrolysis of Host Carbohydrate-Antigens by Streptococcus Pneumoniae Family 98 Glycoside Hydrolases.
J.Biol.Chem., 284, 2009
3QPF
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA-MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 APO-STRUCTURE
Descriptor:Putative uncharacterized protein, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J.
Deposit date:2011-02-12
Release date:2011-03-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QRY
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 1-DEOXYMANNOJIRIMYCIN COMPLEX
Descriptor:Putative uncharacterized protein, 1-DEOXYMANNOJIRIMYCIN, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-18
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QSP
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, STREPTOCOCCUS PNEUMONIAE SP_2144 NON-PRODUCTIVE SUBSTRATE COMPLEX WITH ALPHA-1,6-MANNOBIOSE
Descriptor:Putative uncharacterized protein, BETA-D-MANNOSE, ALPHA-D-MANNOSE, ...
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-21
Release date:2011-03-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QT3
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA-MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, CLOSTRIDIUM PERFRINGENS CPE0426 APO-STRUCTURE
Descriptor:Putative uncharacterized protein CPE0426, 1,2-ETHANEDIOL
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-22
Release date:2011-03-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
3QT9
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ANALYSIS OF A NEW FAMILY OF WIDELY DISTRIBUTED METAL-INDEPENDENT ALPHA MANNOSIDASES PROVIDES UNIQUE INSIGHT INTO THE PROCESSING OF N-LINKED GLYCANS, CLOSTRIDIUM PERFRINGENS CPE0426 COMPLEXED WITH ALPHA-1,6-LINKED 1-THIO-ALPHA-MANNOBIOSE
Descriptor:Putative uncharacterized protein CPE0426, 1,2-ETHANEDIOL, 6-S-alpha-D-mannopyranosyl-6-thio-alpha-D-mannopyranose
Authors:Gregg, K.J., Zandberg, W.F., Hehemann, J.-H., Whitworth, G.E., Deng, L.E., Vocadlo, D.J., Boraston, A.B.
Deposit date:2011-02-22
Release date:2011-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Analysis of a New Family of Widely Distributed Metal-independent {alpha}-Mannosidases Provides Unique Insight into the Processing of N-Linked Glycans.
J.Biol.Chem., 286, 2011
2J4G
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BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH N-BUTYL- THIAZOLINE INHIBITOR
Descriptor:HYALURONOGLUCOSAMINIDASE, (3AR,5R,6S,7R,7AR)-5-(HYDROXYMETHYL)-2-PROPYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL, ACETATE ION, ...
Authors:Dennis, R.J., Davies, G.J.
Deposit date:2006-08-31
Release date:2007-01-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Analysis of Pugnac and Nag-Thiazoline as Transition State Analogues for Human O-Glcnacase: Mechanistic and Structural Insights Into Inhibitor Selectivity and Transition State Poise.
J.Am.Chem.Soc., 129, 2007
4HZM
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) BOUND TO N-[(3S,4R,5R,6R)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)PIPERIDIN-3-YL]BUTANAMIDE
Descriptor:Beta-hexosaminidase, N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-11-15
Release date:2013-06-19
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to beta-Lactams.
Chembiochem, 14, 2013
2VVN
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BTGH84 IN COMPLEX WITH NH-BUTYLTHIAZOLINE
Descriptor:O-GLCNACASE BT_4395, GLYCEROL, AMMONIUM ION, ...
Authors:He, Y., Davies, G.J.
Deposit date:2008-06-10
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Potent Mechanism-Inspired O-Glcnacase Inhibitor that Blocks Phosphorylation of Tau in Vivo.
Nat.Chem.Biol., 4, 2008
3QBW
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID KINASE (ANMK) BOUND TO ADENOSINE DIPHOSPHATE
Descriptor:Anhydro-N-acetylmuramic acid kinase, ADENOSINE-5'-DIPHOSPHATE, SULFATE ION
Authors:Bacik, J.P., Martin, D.R., Mark, B.L.
Deposit date:2011-01-14
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase.
J.Biol.Chem., 286, 2011
3QBX
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CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID KINASE (ANMK) BOUND TO 1,6-ANHYDRO-N-ACTETYLMURAMIC ACID
Descriptor:Anhydro-N-acetylmuramic acid kinase, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, SULFATE ION
Authors:Bacik, J.P., Martin, D.R., Mark, B.L.
Deposit date:2011-01-14
Release date:2011-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase.
J.Biol.Chem., 286, 2011
4AIS
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, GLYCOLIC ACID, GLYCEROL
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
4AIU
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A COMPLEX STRUCTURE OF BTGH84
Descriptor:O-GLCNACASE BT_4395, (3AR,5R,6S,7R,7AR)-2,5-BIS(HYDROXYMETHYL)-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D][1,3]OXAZOLE-6,7-DIOL, CALCIUM ION
Authors:He, Y., Davies, G.J.
Deposit date:2012-02-13
Release date:2012-06-20
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: Intracellular Beta-O-Linked N-Glycolylglucosamine (Glcngc), Udp-Glcngc, and the Biochemical and Structural Rationale for the Substrate Tolerance of Beta-O-Linked Beta-N-Acetylglucosaminidase.
J.Biol.Chem., 287, 2012
4GVF
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) BOUND TO GLCNAC
Descriptor:Beta-hexosaminidase, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GVG
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ)
Descriptor:Beta-hexosaminidase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GVH
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CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) COVALENTLY BOUND TO 5-FLUORO-GLCNAC.
Descriptor:Beta-hexosaminidase, N-[(2S,3R,4R,5S,6S)-6-fluoro-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]acetamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GVI
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CRYSTAL STRUCTURE OF MUTANT (D248N) SALMONELLA TYPHIMURIUM FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) IN COMPLEX WITH GLCNAC-1,6-ANHMURNAC
Descriptor:Beta-hexosaminidase, N-ACETYL-D-GLUCOSAMINE, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, ...
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-08-30
Release date:2012-12-12
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GYJ
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CRYSTAL STRUCTURE OF MUTANT (D318N) BACILLUS SUBTILIS FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) IN COMPLEX WITH GLCNAC-MURNAC (SPACE GROUP P1)
Descriptor:Uncharacterized lipoprotein ybbD, N-ACETYL-D-GLUCOSAMINE, N-ACETYLMURAMIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-09-05
Release date:2012-12-12
Last modified:2015-01-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GYK
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CRYSTAL STRUCTURE OF MUTANT (D318N) BACILLUS SUBTILIS FAMILY 3 GLYCOSIDE HYDROLASE (NAGZ) IN COMPLEX WITH GLCNAC-MURNAC (SPACE GROUP P1211)
Descriptor:Glycoside Hydrolase NagZ, N-ACETYL-D-GLUCOSAMINE, N-ACETYLMURAMIC ACID
Authors:Bacik, J.P., Mark, B.L.
Deposit date:2012-09-05
Release date:2012-12-12
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion.
Chem.Biol., 19, 2012
4GYW
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CRYSTAL STRUCTURE OF HUMAN O-GLCNAC TRANSFERASE IN COMPLEX WITH UDP AND A GLYCOPEPTIDE
Descriptor:UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ...
Authors:Lazarus, M.B., Jiang, J., Gloster, T.M., Zandberg, W.F., Vocadlo, D.J., Walker, S.
Deposit date:2012-09-05
Release date:2012-10-31
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Nat.Chem.Biol., 8, 2012
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