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3FQ9
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DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
Descriptor:Insulin, ZINC ION
Authors:Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
4P65
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CRYSTAL STRUCTURE OF AN CYCLOHEXYLALANINE SUBSTITUTED INSULIN ANALOG.
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2014-03-21
Release date:2014-10-22
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014