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2W82
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THE STRUCTURE OF ARDA
Descriptor:ORF18
Authors:McMahon, S.A., Roberts, G.A., Carter, L.G., Cooper, L.P., Liu, H., White, J.H., Johnson, K.A., Sanghvi, B., Oke, M., Walkinshaw, M.D., Blakely, G., Naismith, J.H., Dryden, D.T.F.
Deposit date:2009-01-08
Release date:2009-01-27
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Extensive DNA Mimicry by the Arda Anti-Restriction Protein and its Role in the Spread of Antibiotic Resistance.
Nucleic Acids Res., 37, 2009
1SRZ
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SOLUTION STRUCTURE OF THE SECOND COMPLEMENT CONTROL PROTEIN (CCP) MODULE OF THE GABA(B)R1A RECEPTOR, PRO-119 TRANS CONFORMER
Descriptor:Gamma-aminobutyric acid type B receptor, subunit 1
Authors:Blein, S., Uhrin, D., Smith, B.O., White, J.H., Barlow, P.N.
Deposit date:2004-03-23
Release date:2004-10-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Analysis of the Complement Control Protein (CCP) Modules of GABAB Receptor 1a: ONLY ONE OF THE TWO CCP MODULES IS COMPACTLY FOLDED
J.Biol.Chem., 279, 2004
1SS2
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SOLUTION STRUCTURE OF THE SECOND COMPLEMENT CONTROL PROTEIN (CCP) MODULE OF THE GABA(B)R1A RECEPTOR, PRO-119 CIS CONFORMER
Descriptor:Gamma-aminobutyric acid type B receptor, subunit 1
Authors:Blein, S., Uhrin, D., Smith, B.O., White, J.H., Barlow, P.N.
Deposit date:2004-03-23
Release date:2004-10-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded.
J.Biol.Chem., 279, 2004
2KMG
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THE STRUCTURE OF THE KLCA AND ARDB PROTEINS SHOW A NOVEL FOLD AND ANTIRESTRICTION ACTIVITY AGAINST TYPE I DNA RESTRICTION SYSTEMS IN VIVO BUT NOT IN VITRO
Descriptor:KlcA
Authors:Serfiotis-Mitsa, D., Herbert, A.P., Roberts, G.A., Soares, D.C., White, J.H., Blakely, G.W., Uhrin, D., Dryden, D.T.F.
Deposit date:2009-07-28
Release date:2009-12-29
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against Type I DNA restriction systems in vivo but not in vitro
Nucleic Acids Res., 38, 2010
2Y7C
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ATOMIC MODEL OF THE OCR-BOUND METHYLASE COMPLEX FROM THE TYPE I RESTRICTION-MODIFICATION ENZYME ECOKI (M2S1). BASED ON FITTING INTO EM MAP 1534.
Descriptor:TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN, TYPE I RESTRICTION ENZYME ECOKI M PROTEIN, GENE 0.3 PROTEIN
Authors:Kennaway, C.K., Obarska-Kosinska, A., White, J.H., Tuszynska, I., Cooper, L.P., Bujnicki, J.M., Trinick, J., Dryden, D.T.F.
Deposit date:2011-01-31
Release date:2011-02-09
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (18 Å)
Cite:The Structure of M.Ecoki Type I DNA Methyltransferase with a DNA Mimic Antirestriction Protein.
Nucleic Acids Res., 37, 2009
2Y7H
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ATOMIC MODEL OF THE DNA-BOUND METHYLASE COMPLEX FROM THE TYPE I RESTRICTION-MODIFICATION ENZYME ECOKI (M2S1). BASED ON FITTING INTO EM MAP 1534.
Descriptor:TYPE-1 RESTRICTION ENZYME ECOKI SPECIFICITY PROTEIN, TYPE I RESTRICTION ENZYME ECOKI M PROTEIN, 5'-D(*GP*TP*TP*CP*AP*AP*CP*GP*TP*CP*GP*AP*CP*GP *TP*GP*CP*AP*AP*C)-3', ...
Authors:Kennaway, C.K., Obarska-Kosinska, A., White, J.H., Tuszynska, I., Cooper, L.P., Bujnicki, J.M., Trinick, J., Dryden, D.T.F.
Deposit date:2011-01-31
Release date:2011-02-09
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (18 Å)
Cite:The Structure of M.Ecoki Type I DNA Methyltransferase with a DNA Mimic Antirestriction Protein.
Nucleic Acids Res., 37, 2009
4FHH
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DEVELOPMENT OF SYNTHETICALLY ACCESSIBLE NON-SECOSTEROIDAL HYBRID MOLECULES COMBINING VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITION
Descriptor:Vitamin D3 receptor A, Nuclear receptor coactivator 2, N-hydroxy-2-{4-[3-(4-{[(2S)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide
Authors:Fischer, J., Wang, T.T., Kaldre, D., Rochel, N., Moras, D., White, J.H., Gleason, J.L.
Deposit date:2012-06-06
Release date:2012-09-19
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.
Chem.Biol., 19, 2012
4FHI
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DEVELOPMENT OF SYNTHETICALLY ACCESSIBLE NON-SECOSTEROIDAL HYBRID MOLECULES COMBINING VITAMIN D RECEPTOR AGONISM AND HISTONE DEACETYLASE INHIBITION
Descriptor:Vitamin Nuclear Receptor, SRC-1, N-hydroxy-2-{4-[3-(4-{[(2R)-2-hydroxy-3,3-dimethylbutyl]oxy}-3-methylphenyl)pentan-3-yl]-2-methylphenoxy}acetamide
Authors:Fischer, J., Wang, T.T., Kaldre, D., Rochel, N., Moras, D., White, J.H., Gleason, J.L.
Deposit date:2012-06-06
Release date:2012-09-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthetically accessible non-secosteroidal hybrid molecules combining vitamin d receptor agonism and histone deacetylase inhibition.
Chem.Biol., 19, 2012
2WJ9
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ARDB
Descriptor:INTERGENIC-REGION PROTEIN, BETA-MERCAPTOETHANOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Weikart, N.D., Roberts, G., Johnson, K.A., Oke, M., Cooper, L.P., McMahon, S.A., White, J.H., Liu, H., Carter, L.G., Walkinshaw, M.D., Blakely, G.W., Naismith, J.H., Dryden, D.T.F.
Deposit date:2009-05-25
Release date:2010-08-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
2YDW
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD2 WITH THE INHIBITOR GW841819X
Descriptor:BROMODOMAIN-CONTAINING PROTEIN 2, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE, SULFATE ION
Authors:Chung, C., Delves, C., Woodward, R., Mirguet, O., Nicodeme, E.
Deposit date:2011-03-24
Release date:2011-06-15
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
J.Med.Chem., 54, 2011
2YEK
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD2 WITH THE INHIBITOR GSK525762 (IBET)
Descriptor:BROMODOMAIN-CONTAINING PROTEIN 2, 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide, SULFATE ION
Authors:Chung, C.W.
Deposit date:2011-03-25
Release date:2011-06-15
Last modified:2012-11-21
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
J.Med.Chem., 54, 2011
2YEL
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X
Descriptor:HUMAN BRD4, 1,2-ETHANEDIOL, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE
Authors:Chung, C.W.
Deposit date:2011-03-25
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
J.Med.Chem., 54, 2011
2YEM
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CRYSTAL STRUCTURE OF THE SECOND BROMODOMAIN OF HUMAN BRD4 WITH THE INHIBITOR GW841819X
Descriptor:BROMODOMAIN-CONTAINING PROTEIN 4, BENZYL [(4R)-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPIN-4-YL]CARBAMATE
Authors:Chung, C.W.
Deposit date:2011-03-25
Release date:2011-06-15
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.
J.Med.Chem., 54, 2011