Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2DUT
DownloadVisualize
BU of 2dut by Molmil
Crystal structure of a M-loop deletion variant of MENT in the native conformation
Descriptor: Heterochromatin-associated protein MENT
Authors:Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
Deposit date:2006-07-26
Release date:2006-08-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Embo J., 25, 2006
2H4Q
DownloadVisualize
BU of 2h4q by Molmil
Crystal structure of a M-loop deletion variant of MENT in the cleaved conformation
Descriptor: Heterochromatin-associated protein MENT
Authors:Whisstock, J.C, Buckle, A.M, McGowan, S, Irving, J.A.
Deposit date:2006-05-25
Release date:2006-07-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
5HN1
DownloadVisualize
BU of 5hn1 by Molmil
Crystal structure of Interleukin-37
Descriptor: Interleukin-37, SULFATE ION
Authors:Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C.
Deposit date:2016-01-17
Release date:2017-02-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
4V3N
DownloadVisualize
BU of 4v3n by Molmil
Membrane bound pleurotolysin prepore (TMH2 strand lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
2VH4
DownloadVisualize
BU of 2vh4 by Molmil
Structure of a loop C-sheet serpin polymer
Descriptor: TENGPIN
Authors:Zhang, Q, Law, R.H.P, Bottomley, S.P, Whisstock, J.C, Buckle, A.M.
Deposit date:2007-11-19
Release date:2008-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A Structural Basis for Loop C-Sheet Polymerization in Serpins.
J.Mol.Biol., 376, 2008
4V2T
DownloadVisualize
BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
7UAC
DownloadVisualize
BU of 7uac by Molmil
Human pro-meprin alpha (zymogen state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Meprin A subunit alpha, ...
Authors:Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
Deposit date:2022-03-12
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAF
DownloadVisualize
BU of 7uaf by Molmil
Human meprin alpha inhibitory complex with compound 10d (N~3~,N~3~-bis[(2H-1,3-benzodioxol-5-yl)methyl]-N-hydroxy-beta-alaninamide)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
Deposit date:2022-03-12
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAE
DownloadVisualize
BU of 7uae by Molmil
Human meprin alpha (active state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
Deposit date:2022-03-12
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAB
DownloadVisualize
BU of 7uab by Molmil
Human pro-meprin alpha (zymogen state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
Deposit date:2022-03-12
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
7UAI
DownloadVisualize
BU of 7uai by Molmil
Meprin alpha helix in complex with fetuin-B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Bayly-Jones, C, Lupton, C.J, Fritz, C, Schlenzig, D, Whisstock, J.C.
Deposit date:2022-03-13
Release date:2022-11-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Helical ultrastructure of the metalloprotease meprin alpha in complex with a small molecule inhibitor.
Nat Commun, 13, 2022
1MTP
DownloadVisualize
BU of 1mtp by Molmil
The X-ray crystal structure of a serpin from a thermophilic prokaryote
Descriptor: Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B
Authors:Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C.
Deposit date:2002-09-21
Release date:2003-04-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment
Structure, 11, 2003
1D5S
DownloadVisualize
BU of 1d5s by Molmil
CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
Descriptor: P1-ARG ANTITRYPSIN
Authors:Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P.
Deposit date:1999-10-11
Release date:2000-04-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
4V3A
DownloadVisualize
BU of 4v3a by Molmil
Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
DownloadVisualize
BU of 4v3m by Molmil
Membrane bound pleurotolysin prepore (TMH2 helix lock) trapped with engineered disulphide cross-link
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
1MI5
DownloadVisualize
BU of 1mi5 by Molmil
The crystal structure of LC13 TcR in complex with HLAB8-EBV peptide complex
Descriptor: Epstein Barr Virus peptide, MHC heavy chain, TcR alpha chain, ...
Authors:Kjer-Nielsen, L, Clements, C.S, Purcell, A.W, Brooks, A.G, Whisstock, J.C, Burrows, S.R, McCluskey, J, Rossjohn, J.
Deposit date:2002-08-21
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Structural Basis for the Selection of Dominant alphabeta T Cell Receptors in Antiviral Immunity
IMMUNITY, 18, 2003
2IY9
DownloadVisualize
BU of 2iy9 by Molmil
Crystal structure of the A-subunit of the AB5 toxin from E. coli
Descriptor: SUBA
Authors:Paton, A.W, Beddoe, T, Thorpe, C.M, Whisstock, J.C, Wilce, M.C.J, Rossjohn, J, Talbot, U.M, Paton, J.C.
Deposit date:2006-07-13
Release date:2006-10-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ab5 Subtilase Cytotoxin Inactivates the Endoplasmic Reticulum Chaperone Bip
Nature, 443, 2006
1SNG
DownloadVisualize
BU of 1sng by Molmil
Structure of a Thermophilic Serpin in the Native State
Descriptor: COG4826: Serine protease inhibitor, SULFATE ION
Authors:Fulton, K.F, Buckle, A.M, Cabrita, L.D, Irving, J.A, Butcher, R.E, Smith, I, Reeve, S, Lesk, A.M, Bottomley, S.P, Rossjohn, J, Whisstock, J.C.
Deposit date:2004-03-10
Release date:2004-12-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
J.Biol.Chem., 280, 2005
1WZ9
DownloadVisualize
BU of 1wz9 by Molmil
The 2.1 A structure of a tumour suppressing serpin
Descriptor: Maspin precursor, SULFATE ION
Authors:Law, R.H, Irving, J.A, Buckle, A.M, Ruzyla, K, Buzza, M, Bashtannyk-Puhalovich, T.A, Beddoe, T.C, Kim, N, Worrall, D.M, Bottomley, S.P, Bird, P.I, Rossjohn, J, Whisstock, J.C.
Deposit date:2005-03-03
Release date:2005-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
J.Biol.Chem., 280, 2005
1XU8
DownloadVisualize
BU of 1xu8 by Molmil
The 2.8 A structure of a tumour suppressing serpin
Descriptor: Maspin, SULFATE ION
Authors:Irving, J.A, Law, R.H, Ruzyla, K, Bashtannyk-Puhalovich, T.A, Kim, N, Worrall, D.M, Rossjohn, J, Whisstock, J.C.
Deposit date:2004-10-25
Release date:2005-03-15
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
J.Biol.Chem., 280, 2005
4WVM
DownloadVisualize
BU of 4wvm by Molmil
Stonustoxin structure
Descriptor: Stonustoxin subunit alpha, Stonustoxin subunit beta
Authors:Ellisdon, A.M, Panjikar, S, Whisstock, J.C, McGowan, S.
Deposit date:2014-11-06
Release date:2015-12-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Stonefish toxin defines an ancient branch of the perforin-like superfamily.
Proc.Natl.Acad.Sci.USA, 112, 2015
1YXA
DownloadVisualize
BU of 1yxa by Molmil
Serpina3n, a murine orthologue of human antichymotrypsin
Descriptor: serine (or cysteine) proteinase inhibitor, clade A, member 3N
Authors:Horvath, A.J, Irving, J.A, Law, R.H, Rossjohn, J, Bottomley, S.P, Quinsey, N.S, Pike, R.N, Coughlin, P.B, Whisstock, J.C.
Deposit date:2005-02-20
Release date:2005-09-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins.
J.Biol.Chem., 280, 2005
4Y1S
DownloadVisualize
BU of 4y1s by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.611 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
4Y1T
DownloadVisualize
BU of 4y1t by Molmil
Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
Descriptor: CALCIUM ION, Perforin-1
Authors:Conroy, P.J, Yagi, H, Whisstock, J.C, Norton, R.S.
Deposit date:2015-02-09
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.666 Å)
Cite:Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes.
J.Biol.Chem., 290, 2015
4YON
DownloadVisualize
BU of 4yon by Molmil
P-Rex1:Rac1 complex
Descriptor: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Lucato, C.M, Whisstock, J.C, Ellisdon, A.M.
Deposit date:2015-03-11
Release date:2015-07-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J.Biol.Chem., 290, 2015

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon