Author results

2DUT
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CRYSTAL STRUCTURE OF A M-LOOP DELETION VARIANT OF MENT IN THE NATIVE CONFORMATION
Descriptor:Heterochromatin-associated protein MENT
Authors:Whisstock, J.C., Buckle, A.M., McGowan, S., Irving, J.A.
Deposit date:2006-07-26
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
Embo J., 25, 2006
2H4Q
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CRYSTAL STRUCTURE OF A M-LOOP DELETION VARIANT OF MENT IN THE CLEAVED CONFORMATION
Descriptor:Heterochromatin-associated protein MENT
Authors:Whisstock, J.C., Buckle, A.M., McGowan, S., Irving, J.A.
Deposit date:2006-05-25
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
2IY9
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CRYSTAL STRUCTURE OF THE A-SUBUNIT OF THE AB5 TOXIN FROM E. COLI
Descriptor:SUBA
Authors:Paton, A.W., Beddoe, T., Thorpe, C.M., Whisstock, J.C., Wilce, M.C.J., Rossjohn, J., Talbot, U.M., Paton, J.C.
Deposit date:2006-07-13
Release date:2006-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ab5 Subtilase Cytotoxin Inactivates the Endoplasmic Reticulum Chaperone Bip
Nature, 443, 2006
5HN1
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CRYSTAL STRUCTURE OF INTERLEUKIN-37
Descriptor:Interleukin-37, SULFATE ION
Authors:Ellisdon, A.M., Nold-Petry, C.A., Nold, M.F., Whisstock, J.C.
Deposit date:2016-01-17
Release date:2017-02-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Homodimerization attenuates the anti-inflammatory activity of interleukin-37.
Sci Immunol, 2, 2017
1D5S
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CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER
Descriptor:P1-ARG ANTITRYPSIN
Authors:Dunstone, M.A., Dai, W., Whisstock, J.C., Rossjohn, J., Pike, R.N., Feil, S.C., Le Bonneic, B.F., Parker, M.W., Bottomley, S.P.
Deposit date:1999-10-11
Release date:2000-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Cleaved antitrypsin polymers at atomic resolution.
Protein Sci., 9, 2000
1MI5
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THE CRYSTAL STRUCTURE OF LC13 TCR IN COMPLEX WITH HLAB8-EBV PEPTIDE COMPLEX
Descriptor:MHC heavy chain, beta 2 microglobulin, Epstein Barr Virus peptide, ...
Authors:Kjer-Nielsen, L., Clements, C.S., Purcell, A.W., Brooks, A.G., Whisstock, J.C., Burrows, S.R., McCluskey, J., Rossjohn, J.
Deposit date:2002-08-21
Release date:2003-02-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Structural Basis for the Selection of Dominant alphabeta T Cell Receptors in Antiviral Immunity
IMMUNITY, 18, 2003
1MTP
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THE X-RAY CRYSTAL STRUCTURE OF A SERPIN FROM A THERMOPHILIC PROKARYOTE
Descriptor:Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B
Authors:Irving, J.A., Cabrita, L.D., Rossjohn, J., Pike, R.N., Bottomley, S.P., Whisstock, J.C.
Deposit date:2002-09-21
Release date:2003-04-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment
Structure, 11, 2003
1SNG
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STRUCTURE OF A THERMOPHILIC SERPIN IN THE NATIVE STATE
Descriptor:COG4826: Serine protease inhibitor, SULFATE ION
Authors:Fulton, K.F., Buckle, A.M., Cabrita, L.D., Irving, J.A., Butcher, R.E., Smith, I., Reeve, S., Lesk, A.M., Bottomley, S.P., Rossjohn, J., Whisstock, J.C.
Deposit date:2004-03-10
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
J.Biol.Chem., 280, 2005
1WZ9
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THE 2.1 A STRUCTURE OF A TUMOUR SUPPRESSING SERPIN
Descriptor:Maspin precursor, SULFATE ION
Authors:Law, R.H., Irving, J.A., Buckle, A.M., Ruzyla, K., Buzza, M., Bashtannyk-Puhalovich, T.A., Beddoe, T.C., Kim, N., Worrall, D.M., Bottomley, S.P., Bird, P.I., Rossjohn, J., Whisstock, J.C.
Deposit date:2005-03-03
Release date:2005-03-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
J.Biol.Chem., 280, 2005
1XU8
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THE 2.8 A STRUCTURE OF A TUMOUR SUPPRESSING SERPIN
Descriptor:Maspin, SULFATE ION
Authors:Irving, J.A., Law, R.H., Ruzyla, K., Bashtannyk-Puhalovich, T.A., Kim, N., Worrall, D.M., Rossjohn, J., Whisstock, J.C.
Deposit date:2004-10-25
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix.
J.Biol.Chem., 280, 2005
1YXA
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SERPINA3N, A MURINE ORTHOLOGUE OF HUMAN ANTICHYMOTRYPSIN
Descriptor:serine (or cysteine) proteinase inhibitor, clade A, member 3N
Authors:Horvath, A.J., Irving, J.A., Law, R.H., Rossjohn, J., Bottomley, S.P., Quinsey, N.S., Pike, R.N., Coughlin, P.B., Whisstock, J.C.
Deposit date:2005-02-20
Release date:2005-09-06
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of the murine homologue of human antichymotrypsin
To be Published
2AK4
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CRYSTAL STRUCTURE OF SB27 TCR IN COMPLEX WITH HLA-B*3508-13MER PEPTIDE
Descriptor:HLA-B35 variant, Beta-2-microglobulin, EBV peptide LPEPLPQGQLTAY, ...
Authors:Tynan, F.E., Burrows, S.R., Buckle, A.M., Clements, C.S., Borg, N.A., Miles, J.J., Beddoe, T., Whisstock, J.C., Wilce, M.C., Silins, S.L., Burrows, J.M., Kjer-Nielsen, L., Konstenko, L., Purcell, A.W., McCluskey, J., Rossjohn, J.
Deposit date:2005-08-03
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
Nat.Immunol., 6, 2005
2ANT
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THE 2.6 A STRUCTURE OF ANTITHROMBIN INDICATES A CONFORMATIONAL CHANGE AT THE HEPARIN BINDING SITE
Descriptor:ANTITHROMBIN, N-ACETYL-D-ALLOSAMINE
Authors:Skinner, R., Abrahams, J.-P., Whisstock, J.C., Lesk, A.M., Carrell, R.W., Wardell, M.R.
Deposit date:1997-01-28
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The 2.6 A structure of antithrombin indicates a conformational change at the heparin binding site.
J.Mol.Biol., 266, 1997
2GPZ
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TRANSTHYRETIN-LIKE PROTEIN FROM SALMONELLA DUBLIN
Descriptor:transthyretin-like protein, SULFATE ION
Authors:Buckle, A.M., Law, R.H., Whisstock, J.C.
Deposit date:2006-04-19
Release date:2006-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Crystal Structure of the Transthyretin-like Protein from Salmonella dublin, a Prokaryote 5-Hydroxyisourate Hydrolase.
J.Mol.Biol., 359, 2006
2H4P
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CRYSTAL STRUCTURE OF WILDTYPE MENT IN THE CLEAVED CONFORMATION
Descriptor:Heterochromatin-associated protein MENT
Authors:Buckle, A.M., McGowan, S., Irving, J.A., Whisstock, J.C.
Deposit date:2006-05-24
Release date:2006-07-18
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
2H4R
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CRYSTAL STRUCTURE OF WILDTYPE MENT IN THE NATIVE CONFORMATION
Descriptor:Heterochromatin-associated protein MENT
Authors:Irving, J.A., Whisstock, J.C., Buckle, A.M., McGowan, S.
Deposit date:2006-05-25
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.
Embo J., 25, 2006
2NW0
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CRYSTAL STRUCTURE OF A LYSIN
Descriptor:PlyB, ACETATE ION
Authors:Porter, C.J., Buckle, A.M., Whisstock, J.C.
Deposit date:2006-11-14
Release date:2006-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The 1.6 A Crystal Structure of the Catalytic Domain of PlyB, a Bacteriophage Lysin Active Against Bacillus anthracis.
J.Mol.Biol., 366, 2007
2OKJ
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THE X-RAY CRYSTAL STRUCTURE OF THE 67KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD67)
Descriptor:Glutamate decarboxylase 1, GAMMA-AMINO-BUTANOIC ACID, 4-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]BUTANOIC ACID
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
2OKK
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THE X-RAY CRYSTAL STRUCTURE OF THE 65KDA ISOFORM OF GLUTAMIC ACID DECARBOXYLASE (GAD65)
Descriptor:Glutamate decarboxylase 2, GAMMA-AMINO-BUTANOIC ACID, GLYCEROL
Authors:Buckle, A.M., Fenalti, G., Law, R.H.P., Whisstock, J.C.
Deposit date:2007-01-17
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop.
Nat.Struct.Mol.Biol., 14, 2007
2PEE
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CRYSTAL STRUCTURE OF A THERMOPHILIC SERPIN, TENGPIN, IN THE NATIVE STATE
Descriptor:Serine protease inhibitor, SULFATE ION, GLYCEROL
Authors:Zhang, Q.W., Buckle, A.M., Whisstock, J.C.
Deposit date:2007-04-02
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The N terminus of the serpin, tengpin, functions to trap the metastable native state.
Embo Rep., 8, 2007
2PEF
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CRYSTAL STRUCTURE OF A THERMOPHILIC SERPIN, TENGPIN, IN THE LATENT STATE
Descriptor:Serine protease inhibitor
Authors:Zhang, Q.W., Buckle, A.M., Whisstock, J.C.
Deposit date:2007-04-03
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The N terminus of the serpin, tengpin, functions to trap the metastable native state.
Embo Rep., 8, 2007
2QP2
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STRUCTURE OF A MACPF/PERFORIN-LIKE PROTEIN
Descriptor:Unknown protein, CALCIUM ION
Authors:Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W.T., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J.C.
Deposit date:2007-07-22
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:A common fold mediates vertebrate defense and bacterial attack
Science, 317, 2007
2R9Y
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STRUCTURE OF ANTIPLASMIN
Descriptor:Alpha-2-antiplasmin
Authors:Law, R.H.P., Sofian, T., Kan, W.T., Horvath, A.J., Hitchen, C.R., Langendorf, C.G., Buckle, A.M., Whisstock, J.C., Coughlin, P.B.
Deposit date:2007-09-14
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin
Blood, 111, 2008
2VH4
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STRUCTURE OF A LOOP C-SHEET SERPIN POLYMER
Descriptor:TENGPIN
Authors:Zhang, Q., Law, R.H.P., Bottomley, S.P., Whisstock, J.C., Buckle, A.M.
Deposit date:2007-11-19
Release date:2008-01-08
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A Structural Basis for Loop C-Sheet Polymerization in Serpins.
J.Mol.Biol., 376, 2008
3EBG
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STRUCTURE OF THE M1 ALANYLAMINOPEPTIDASE FROM MALARIA
Descriptor:M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ...
Authors:McGowan, S., Porter, C.J., Buckle, A.M., Whisstock, J.C.
Deposit date:2008-08-27
Release date:2009-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Proc.Natl.Acad.Sci.USA, 106, 2009
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