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7LEW
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BU of 7lew by Molmil
Crystal structure of UBE2G2 in complex with the UBE2G2-binding region of AUP1
Descriptor: Lipid droplet-regulating VLDL assembly factor AUP1, Ubiquitin-conjugating enzyme E2 G2
Authors:Liang, Y.-H, Smith, C.E, Tsai, Y.C, Weissman, A.M, Ji, X.
Deposit date:2021-01-15
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.736 Å)
Cite:A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.
Plos Biol., 19, 2021
4JQU
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BU of 4jqu by Molmil
Crystal structure of Ubc7p in complex with the U7BR of Cue1p
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Coupling of ubiquitin conjugation to ER degradation protein 1, DI(HYDROXYETHYL)ETHER, ...
Authors:Liang, Y.-H, Metzger, M.B, Weissman, A.M, Ji, X.
Deposit date:2013-03-20
Release date:2013-05-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms.
Mol.Cell, 50, 2013
5D1L
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BU of 5d1l by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A)
Descriptor: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ...
Authors:Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
Deposit date:2015-08-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.618 Å)
Cite:Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
5D1K
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BU of 5d1k by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
Authors:Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
Deposit date:2015-08-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
5D1M
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BU of 5d1m by Molmil
Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A)
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ...
Authors:Liang, Y.-H, Li, S, Weissman, A.M, Ji, X.
Deposit date:2015-08-04
Release date:2015-10-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.581 Å)
Cite:Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
J.Biol.Chem., 290, 2015
2LVP
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BU of 2lvp by Molmil
gp78CUE domain bound to the distal ubiquitin of K48-linked diubiquitin
Descriptor: E3 ubiquitin-protein ligase AMFR, Ubiquitin
Authors:Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R.
Deposit date:2012-07-09
Release date:2012-11-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
2LVN
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BU of 2lvn by Molmil
Structure of the gp78 CUE domain
Descriptor: E3 ubiquitin-protein ligase AMFR
Authors:Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R.
Deposit date:2012-07-09
Release date:2012-11-21
Last modified:2012-12-26
Method:SOLUTION NMR
Cite:Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
2LVQ
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BU of 2lvq by Molmil
gp78CUE domain bound to the proximal ubiquitin of K48-linked diubiquitin
Descriptor: E3 ubiquitin-protein ligase AMFR, Ubiquitin
Authors:Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R.
Deposit date:2012-07-09
Release date:2012-11-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
2LVO
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BU of 2lvo by Molmil
Structure of the gp78CUE domain bound to monubiquitin
Descriptor: E3 ubiquitin-protein ligase AMFR, Ubiquitin
Authors:Liu, S, Chen, Y, Huang, T, Tarasov, S.G, King, A, Li, J, Weissman, A.M, Byrd, R.A, Das, R.
Deposit date:2012-07-09
Release date:2012-11-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Promiscuous Interactions of gp78 E3 Ligase CUE Domain with Polyubiquitin Chains.
Structure, 20, 2012
6OP8
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BU of 6op8 by Molmil
S. pombe Ubc7/U7BR complex
Descriptor: 1,2-ETHANEDIOL, CUE domain-containing protein 4, mitochondrial, ...
Authors:Hann, Z.S, Lima, C.D.
Deposit date:2019-04-24
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.703 Å)
Cite:Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7.
Acta Crystallogr.,Sect.F, 75, 2019
3H8K
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BU of 3h8k by Molmil
Crystal structure of Ube2g2 complxed with the G2BR domain of gp78 at 1.8-A resolution
Descriptor: Autocrine motility factor receptor, isoform 2, Ubiquitin-conjugating enzyme E2 G2
Authors:Kalathur, R.C, Das, R, Li, J, Byrd, R.A, Ji, X.
Deposit date:2009-04-29
Release date:2009-07-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Mol.Cell, 34, 2009
4LAD
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BU of 4lad by Molmil
Crystal Structure of the Ube2g2:RING-G2BR complex
Descriptor: E3 ubiquitin-protein ligase AMFR, OXALATE ION, Ubiquitin-conjugating enzyme E2 G2, ...
Authors:Liang, Y.-H, Li, J, Das, R, Byrd, R.A, Ji, X.
Deposit date:2013-06-19
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
Embo J., 32, 2013
2LXP
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BU of 2lxp by Molmil
NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g
Descriptor: E3 ubiquitin-protein ligase AMFR, Ubiquitin-conjugating enzyme E2 G2, ZINC ION
Authors:Das, R, Linag, Y, Mariano, J, Li, J, Huang, T, King, A, Weissman, A, Ji, X, Byrd, R.
Deposit date:2012-08-30
Release date:2013-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
Embo J., 32, 2013
2LXH
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BU of 2lxh by Molmil
NMR structure of the RING domain in ubiquitin ligase gp78
Descriptor: E3 ubiquitin-protein ligase AMFR, ZINC ION
Authors:Das, R, Linag, Y, Mariano, J, Li, J, Huang, T, King, A, Weissman, A, Ji, X, Byrd, R.
Deposit date:2012-08-27
Release date:2013-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine.
Embo J., 32, 2013
2FID
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BU of 2fid by Molmil
Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
Descriptor: Rab5 GDP/GTP exchange factor, Ubiquitin, ZINC ION
Authors:Lee, S, Hurley, J.H.
Deposit date:2005-12-29
Release date:2006-02-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5
Nat.Struct.Mol.Biol., 13, 2006
2FIF
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BU of 2fif by Molmil
Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
Descriptor: Rab5 GDP/GTP exchange factor, SULFATE ION, Ubiquitin, ...
Authors:Lee, S, Hurley, J.H.
Deposit date:2005-12-29
Release date:2006-02-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5
Nat.Struct.Mol.Biol., 13, 2006
6SQO
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BU of 6sqo by Molmil
Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
6SQS
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BU of 6sqs by Molmil
Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub
Descriptor: E3 ubiquitin-protein ligase Mdm2, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
6SQP
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BU of 6sqp by Molmil
Crystal structure of Cat MDM2-S429E RING domain homodimer
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
6SQR
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BU of 6sqr by Molmil
Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
2F4W
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BU of 2f4w by Molmil
Human ubiquitin-conjugating enzyme E2 J2
Descriptor: ubiquitin-conjugating enzyme E2, J2
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Finerty Jr, P.J, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2005-11-24
Release date:2005-12-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012

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