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2X2R
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BU of 2x2r by Molmil
Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((4-chlorophenyl)diphenylmethylthio)propanoic acid
Descriptor: (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, KINESIN-LIKE PROTEIN KIF11, ...
Authors:Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F.
Deposit date:2010-01-15
Release date:2011-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2XAE
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BU of 2xae by Molmil
Crystal structure of human kinesin Eg5 in complex with (R)-2-amino-3-((S)-2-methyl-1,1-diphenylbutylthio)propanoic acid
Descriptor: (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
Authors:Kaan, H.Y.K, Weiss, J, Menger, D, Ulaganathan, V, Tkocz, K, Laggner, C, Popowycz, F, Joseph, B, Kozielski, F.
Deposit date:2010-03-31
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
8OSK
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BU of 8osk by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL+5.8 (composite map)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Stoos, L, Michael, A.K, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OTT
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BU of 8ott by Molmil
MYC-MAX bound to a nucleosome at SHL+5.8
Descriptor: DNA (144-MER), Histone H2A type 1-B/E, Histone H2A type 1-K, ...
Authors:Stoos, L, Michael, A.K, Kempf, G, Kater, L, Cavadini, S, Thoma, N.
Deposit date:2023-04-21
Release date:2023-05-24
Last modified:2023-09-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OSL
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BU of 8osl by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to the native Por enhancer nucleosome (map 2, additional 3D classification and flexible refinement)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (147-MER), ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OSJ
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BU of 8osj by Molmil
Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)
Descriptor: Basic helix-loop-helix ARNT-like protein 1, Circadian locomoter output cycles protein kaput, DNA (124-MER), ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.H.
Deposit date:2023-04-19
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
8OTS
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BU of 8ots by Molmil
OCT4 and MYC-MAX co-bound to a nucleosome
Descriptor: DNA (127-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Stoos, L, Kempf, G, Cavadini, S, Thoma, N.
Deposit date:2023-04-21
Release date:2023-05-24
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cooperation between bHLH transcription factors and histones for DNA access.
Nature, 619, 2023
6Y5E
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BU of 6y5e by Molmil
Structure of human cGAS (K394E) bound to the nucleosome (focused refinement of cGAS-NCP subcomplex)
Descriptor: Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-C, ...
Authors:Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H.
Deposit date:2020-02-25
Release date:2020-09-23
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural mechanism of cGAS inhibition by the nucleosome.
Nature, 587, 2020
6YOV
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BU of 6yov by Molmil
OCT4-SOX2-bound nucleosome - SHL+6
Descriptor: DNA (142-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2020-04-15
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.42 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
6Y5D
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BU of 6y5d by Molmil
Structure of human cGAS (K394E) bound to the nucleosome
Descriptor: Cyclic GMP-AMP synthase, DNA (153-MER), Histone H2A type 2-A, ...
Authors:Pathare, G.R, Cavadini, S, Kempf, G, Thoma, N.H.
Deposit date:2020-02-25
Release date:2020-09-23
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural mechanism of cGAS inhibition by the nucleosome.
Nature, 587, 2020
6T90
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BU of 6t90 by Molmil
OCT4-SOX2-bound nucleosome - SHL-6
Descriptor: DNA (146-MER), Green fluorescent protein,POU domain, class 5, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2019-10-25
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
6T93
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BU of 6t93 by Molmil
Nucleosome with OCT4-SOX2 motif at SHL-6
Descriptor: DNA (153-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
Authors:Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H.
Deposit date:2019-10-25
Release date:2020-05-06
Last modified:2020-07-08
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Mechanisms of OCT4-SOX2 motif readout on nucleosomes.
Science, 368, 2020
1BP1
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BU of 1bp1 by Molmil
CRYSTAL STRUCTURE OF BPI, THE HUMAN BACTERICIDAL PERMEABILITY-INCREASING PROTEIN
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN
Authors:Beamer, L.J, Carroll, S.F, Eisenberg, D.
Deposit date:1997-04-08
Release date:1997-09-04
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution.
Science, 276, 1997

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