Author results

1W1I
  • Download 1w1i
  • View 1w1i
Molmil generated image of 1w1i
CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
分子名称:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, N-ACETYL-D-GLUCOSAMINE, ...
著者Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
登録日2004-06-22
公開日2004-09-02
最終更新日2018-07-25
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface.
J. Biol. Chem., 279, 2004
2BGN
  • Download 2bgn
  • View 2bgn
Molmil generated image of 2bgn
HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT(1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
分子名称:DIPEPTIDYL PEPTIDASE IV, ADENOSINE DEAMINASE, TAT PROTEIN, ...
著者Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
登録日2005-01-03
公開日2005-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26)
J.Biol.Chem., 280, 2005
2BGR
  • Download 2bgr
  • View 2bgr
Molmil generated image of 2bgr
CRYSTAL STRUCTURE OF HIV-1 TAT DERIVED NONAPEPTIDES TAT(1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)
分子名称:DIPEPTIDYL PEPTIDASE IV, HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE, N-ACETYL-D-GLUCOSAMINE, ...
著者Weihofen, W.A., Liu, J., Reutter, W., Saenger, W., Fan, H.
登録日2005-01-04
公開日2005-01-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structures of HIV-1 Tat-Derived Nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) Bound to the Active Site of Dipeptidyl-Peptidase Iv (Cd26)
J.Biol.Chem., 280, 2005
2BNW
  • Download 2bnw
  • View 2bnw
Molmil generated image of 2bnw
STRUCTURAL BASIS FOR COOPERATIVE BINDING OF RIBBON-HELIX-HELIX OMEGA REPRESSOR TO DIRECT DNA HEPTAD REPEATS
分子名称:ORF OMEGA, 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*AP *TP*CP*AP*CP*AP*AP*GP*C)-3', 5'-D(*CP*TP*TP*GP*TP*GP*AP*TP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3'
著者Weihofen, W.A., Cicek, A., Pratto, F., Alonso, J.C., Saenger, W.
登録日2005-04-05
公開日2006-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription.
Nucleic Acids Res., 34, 2006
2BNZ
  • Download 2bnz
  • View 2bnz
Molmil generated image of 2bnz
STRUCTURAL BASIS FOR COOPERATIVE BINDING OF RIBBON-HELIX-HELIX OMEGA REPRESSOR TO INVERTED DNA HEPTAD REPEATS
分子名称:ORF OMEGA, 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*GP *TP*GP*AP*TP*TP*AP*GP*C)-3', 5'-D(*CP*TP*AP*AP*TP*CP*AP*CP*TP*TP *GP*TP*GP*AP*TP*TP*CP*G)-3'
著者Weihofen, W.A., Cicek, A., Pratto, F., Alonso, J.C., Saenger, W.
登録日2005-04-06
公開日2006-03-15
最終更新日2015-10-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription.
Nucleic Acids Res., 34, 2006
2CAX
  • Download 2cax
  • View 2cax
Molmil generated image of 2cax
STRUCTURAL BASIS FOR COOPERATIVE BINDING OF RIBBON-HELIX-HELIX REPRESSOR OMEGA TO MUTATED DIRECT DNA HEPTAD REPEATS
分子名称:ORF OMEGA, 5'-D(*GP*AP*AP*TP*CP*AP*CP*AP*AP*AP *TP*CP*AP*CP*AP*AP*G)-3', 5'-D(*TP*TP*GP*TP*GP*AP*TP*TP*TP*GP *TP*GP*AP*TP*TP*CP*G)-3', ...
著者Weihofen, W.A., Cicek, A., Pratto, F., Alonso, J.C., Saenger, W.
登録日2005-12-23
公開日2006-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structures of Omega Repressors Bound to Direct and Inverted DNA Repeats Explain Modulation of Transcription.
Nucleic Acids Res., 34, 2006
2CH5
  • Download 2ch5
  • View 2ch5
Molmil generated image of 2ch5
CRYSTAL STRUCTURE OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN COMPLEX WITH N-ACETYLGLUCOSAMINE
分子名称:NAGK PROTEIN, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
著者Weihofen, W.A., Berger, M., Chen, H., Saenger, W., Hinderlich, S.
登録日2006-03-13
公開日2006-09-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation.
J.Mol.Biol., 364, 2006
2CH6
  • Download 2ch6
  • View 2ch6
Molmil generated image of 2ch6
CRYSTAL STRUCTURE OF HUMAN N-ACETYLGLUCOSAMINE KINASE IN COMPLEX WITH ADP AND GLUCOSE
分子名称:N-ACETYL-D-GLUCOSAMINE KINASE, ADENOSINE-5'-DIPHOSPHATE, ALPHA-D-GLUCOSE
著者Weihofen, W.A., Berger, M., Chen, H., Saenger, W., Hinderlich, S.
登録日2006-03-13
公開日2006-09-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation.
J.Mol.Biol., 364, 2006
2WDT
  • Download 2wdt
  • View 2wdt
Molmil generated image of 2wdt
CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM UCHL3 IN COMPLEX WITH THE SUICIDE INHIBITOR UBVME
分子名称:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3, UBIQUITIN, CHLORIDE ION
著者Weihofen, W.A., Artavanis-Tsakonas, K., Gaudet, R., Ploegh, H.L.
登録日2009-03-26
公開日2009-12-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
2WE6
  • Download 2we6
  • View 2we6
Molmil generated image of 2we6
CRYSTAL STRUCTURE OF PLASMODIUM FALCIPARUM UBIQUITIN CARBOXYL- TERMINAL HYDROLASE 3 (UCHL3)
分子名称:UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3
著者Weihofen, W.A., Artavanis-Tsakonas, K., Gaudet, R., Ploegh, H.L.
登録日2009-03-27
公開日2009-12-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
6ATB
  • Download 6atb
  • View 6atb
Molmil generated image of 6atb
CRYSTAL STRUCTURE OF HUMAN NAMPT IN COMPLEX WITH NVP-LOD812
分子名称:Nicotinamide phosphoribosyltransferase, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-N'-[(pyridin-3-yl)methyl]urea, GLYCEROL, ...
著者Weihofen, W.A., Thigale, S.
登録日2017-08-28
公開日2018-09-12
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
6AZJ
  • Download 6azj
  • View 6azj
Molmil generated image of 6azj
CRYSTAL STRUCTURE OF HUMAN NAMPT IN COMPLEX WITH NVP-LQN520
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide
著者Weihofen, W.A., Thigale, S.
登録日2017-09-11
公開日2018-09-12
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
6B75
  • Download 6b75
  • View 6b75
Molmil generated image of 6b75
CRYSTAL STRUCTURE OF HUMAN NAMPT IN COMPLEX WITH NVP-LOQ594
分子名称:Nicotinamide phosphoribosyltransferase, 4-[(piperazin-1-yl)methyl]-N-{[4-({[(pyridin-3-yl)methyl]carbamoyl}amino)phenyl]methyl}benzamide
著者Weihofen, W.A., Thigale, S.
登録日2017-10-03
公開日2018-10-03
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
6B76
  • Download 6b76
  • View 6b76
Molmil generated image of 6b76
CRYSTAL STRUCTURE OF HUMAN NAMPT IN COMPLEX WITH NVP-LVR596
分子名称:Nicotinamide phosphoribosyltransferase, (1S,2S)-N-{4-[(1S)-1-(propanoylamino)ethyl]phenyl}-2-(pyridin-3-yl)cyclopropane-1-carboxamide, PHOSPHATE ION
著者Weihofen, W.A., Thigale, S.
登録日2017-10-03
公開日2018-10-03
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Identification and structure based design of cellularly active cyclo-propyl carboxamide Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
To Be Published
1GSZ
  • Download 1gsz
  • View 1gsz
Molmil generated image of 1gsz
CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, [4-({6-[ALLYL(METHYL)AMINO]HEXYL}OXY)-2-FLUOROPHENYL](4-BROMOPHENYL)METHANONE
著者Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E.
登録日2002-01-09
公開日2003-01-16
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Chem.Biol., 9, 2002
2J7Q
  • Download 2j7q
  • View 2j7q
Molmil generated image of 2j7q
CRYSTAL STRUCTURE OF THE UBIQUITIN-SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN M48 IN COMPLEX WITH A UBQUITIN-BASED SUICIDE SUBSTRATE
分子名称:MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEASE, M48USP, UBIQUITIN, ...
著者Schlieker, C., Weihofen, W.A., Frijns, E., Kattenhorn, L.M., Gaudet, R., Ploegh, H.L.
登録日2006-10-16
公開日2007-03-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
Mol.Cell, 25, 2007
4ZI8
  • Download 4zi8
  • View 4zi8
Molmil generated image of 4zi8
STRUCTURE OF MOUSE CLUSTERED PCDHGC3 EC1-3
分子名称:Protein Pcdhgc3, CALCIUM ION, CHLORIDE ION, ...
著者Nicoludis, J.M., Lau, S.-Y., Scharfe, C.P.I., Marks, D.S., Weihofen, W.A., Gaudet, R.
登録日2015-04-27
公開日2015-10-28
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
Structure, 23, 2015
4ZI9
  • Download 4zi9
  • View 4zi9
Molmil generated image of 4zi9
STRUCTURE OF MOUSE CLUSTERED PCDHGA1 EC1-3
分子名称:MCG133388, isoform CRA_t, CALCIUM ION
著者Nicoludis, J.M., Lau, S.-Y., Scharfe, C.P.I., Marks, D.S., Weihofen, W.A., Gaudet, R.
登録日2015-04-27
公開日2015-10-28
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.
Structure, 23, 2015
5KTE
  • Download 5kte
  • View 5kte
Molmil generated image of 5kte
CRYSTAL STRUCTURE OF DEINOCOCCUS RADIODURANS MNTH, AN NRAMP-FAMILY TRANSITION METAL TRANSPORTER
分子名称:Divalent metal cation transporter MntH, Fab Heavy Chain, Fab Light Chain, ...
著者Bane, L.B., Gaudet, R., Weihofen, W.A., Singharoy, A.
登録日2016-07-11
公開日2016-11-23
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (3.941 Å)
主引用文献Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.
Structure, 24, 2016
1H35
  • Download 1h35
  • View 1h35
Molmil generated image of 1h35
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4'-{[ALLYL(METHYL)AMINO]METHYL}-1,1'-BIPHENYL-4-YL)(4-BROMOPHENYL)METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H36
  • Download 1h36
  • View 1h36
Molmil generated image of 1h36
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (4-BROMOPHENYL)[4-({(2E)-4-[CYCLOPROPYL(METHYL)AMINO]BUT-2-ENYL}OXY)PHENYL]METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
  • Download 1h37
  • View 1h37
Molmil generated image of 1h37
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, {4-[((1S,2S)-2-{[ALLYL(CYCLOPROPYL)AMINO]METHYL}CYCLOPROPYL)METHOXY]PHENYL}(4-BROMOPHENYL)METHANONE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H39
  • Download 1h39
  • View 1h39
Molmil generated image of 1h39
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3A
  • Download 1h3a
  • View 1h3a
Molmil generated image of 1h3a
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO AN HOMOLOGOUS ENZYME
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, (2E)-N-ALLYL-4-{[3-(4-BROMOPHENYL)-5-FLUORO-1-METHYL-1H-INDAZOL-6-YL]OXY}-N-METHYL-2-BUTEN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-24
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3B
  • Download 1h3b
  • View 1h3b
Molmil generated image of 1h3b
SQUALENE-HOPENE CYCLASE
分子名称:SQUALENE--HOPENE CYCLASE, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, N-{6-[4-(6-BROMO-1,2-BENZISOTHIAZOL-3-YL)PHENOXY]HEXYL}-N-METHYL-2-PROPEN-1-AMINE
著者Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
登録日2002-08-25
公開日2003-08-21
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
<12>