Author results

2PP4
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SOLUTION STRUCTURE OF ETO-TAFH REFINED IN EXPLICIT SOLVENT
分子名称:Protein ETO
著者Wei, Y., Liu, S., Lausen, J., Woodrell, C., Cho, S., Biris, N., Kobayashi, N., Yokoyama, S., Werner, M.H.
登録日2007-04-27
公開日2007-06-19
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
Nat.Struct.Mol.Biol., 14, 2007
1ESC
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
分子名称:ESTERASE
著者Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
登録日1994-10-07
公開日1995-10-15
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1FTN
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CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
分子名称:TRANSFORMING PROTEIN RHOA (H12), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.
登録日1997-03-13
公開日1998-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of RhoA-GDP and its functional implications.
Nat.Struct.Biol., 4, 1997
6E16
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TERNARY STRUCTURE OF C-MYC-TBP-TAF1
分子名称:Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein
著者Wei, Y., Dong, A., Sunnerhagen, M., Penn, L., Tong, Y., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
登録日2018-07-09
公開日2019-10-02
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Multiple direct interactions of TBP with the MYC oncoprotein.
Nat.Struct.Mol.Biol., 26, 2019
6E24
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TERNARY STRUCTURE OF C-MYC-TBP-TAF1
分子名称:Transcription initiation factor TFIID subunit 1,Myc proto-oncogene protein,TATA-box-binding protein
著者Wei, Y., Dong, A., Sunnerhagen, M., Penn, L., Tong, Y., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
登録日2018-07-10
公開日2019-10-02
最終更新日2019-11-27
実験手法X-RAY DIFFRACTION (3.001 Å)
主引用文献Multiple direct interactions of TBP with the MYC oncoprotein.
Nat.Struct.Mol.Biol., 26, 2019
4I8O
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CRYSTAL STRUCTURE OF THE TOXIN RNLA FROM ESCHERICHIA COLI
分子名称:TOXIN RNLA
著者Wei, Y., Gao, Z.Q., Zhang, H., Dong, Y.H.
登録日2012-12-04
公開日2013-10-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.104 Å)
主引用文献Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance.
Mol.Microbiol., 90, 2013
1ESD
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
分子名称:ESTERASE, METHYLPHOSPHONIC ACID ESTER GROUP
著者Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
登録日1994-10-07
公開日1995-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1ESE
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
分子名称:ESTERASE, DIETHYL PHOSPHONATE
著者Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
登録日1994-10-07
公開日1995-10-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1F1J
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CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO
分子名称:CASPASE-7 PROTEASE, ACE-ASP-GLU-VAL-ASP-CHO, SULFATE ION
著者Wei, Y., Charifson, P.S.
登録日2000-05-19
公開日2001-05-23
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Chem.Biol., 7, 2000
1JFR
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CRYSTAL STRUCTURE OF THE STREPTOMYCES EXFOLIATUS LIPASE AT 1.9A RESOLUTION: A MODEL FOR A FAMILY OF PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES
分子名称:LIPASE
著者Wei, Y., Derewenda, Z.S.
登録日1997-07-11
公開日1998-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure, 6, 1998
1JKM
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BREFELDIN A ESTERASE, A BACTERIAL HOMOLOGUE OF HUMAN HORMONE SENSITIVE LIPASE
分子名称:BREFELDIN A ESTERASE
著者Wei, Y., Contreras, A.J., Sheffield, P., Osterlund, T., Derewenda, U., Matern, U.O., Derewenda, Z.S.
登録日1998-02-04
公開日1999-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase.
Nat.Struct.Biol., 6, 1999
1P68
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SOLUTION STRUCTURE OF S-824, A DE NOVO DESIGNED FOUR HELIX BUNDLE
分子名称:De novo designed protein S-824
著者Wei, Y., Kim, S., Fela, D., Baum, J., Hecht, M.H.
登録日2003-04-29
公開日2003-11-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a de novo protein from a designed combinatorial library.
Proc.Natl.Acad.Sci.Usa, 100, 2003
2QV1
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CRYSTAL STRUCTURE OF HCV NS3-4A V36M MUTANT
分子名称:NS3, peptide, ZINC ION
著者Wei, Y.
登録日2007-08-07
公開日2008-08-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Phenotypic and Structural Analyses of HCV NS3 Protease Val36 Variants
To be Published
3FV5
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CRYSTAL STRUCTURE OF E. COLI TOPOISOMERASE IV CO-COMPLEXED WITH INHIBITOR
分子名称:DNA topoisomerase 4 subunit B, 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea
著者Wei, Y., Charifson, P., LeTiran, A.
登録日2009-01-15
公開日2010-01-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
To be Published
5I8J
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CRYSTAL STRUCTURE OF DMD FROM PHAGE RB69
分子名称:Dmd discriminator of mRNA degradation
著者Wei, Y., Zhang, H., Gao, Z.Q., Dong, Y.H.
登録日2016-02-19
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA
Biochem. Biophys. Res. Commun., 472, 2016
6E7O
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CRYSTAL STRUCTURE OF DEGLYCOSYLATED HUMAN EPDR1
分子名称:Mammalian ependymin-related protein 1
著者Wei, Y., Prive, G.G.
登録日2018-07-27
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
Commun Biol, 2, 2019
6E8N
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CRYSTAL STRUCTURE OF GLYCOSYLATED HUMAN EPDR1
分子名称:Mammalian ependymin-related protein 1, NONAETHYLENE GLYCOL
著者Wei, Y., Prive, G.G.
登録日2018-07-30
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
Commun Biol, 2, 2019
6BY9
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CRYSTAL STRUCTURE OF EHMT1
分子名称:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
著者Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
登録日2017-12-20
公開日2018-01-31
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of EHMT1
to be published
2OIN
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CRYSTAL STRUCTURE OF HCV NS3-4A R155K MUNTANT
分子名称:Polyprotein, NS4A peptide, ZINC ION
著者Wei, Y.
登録日2007-01-11
公開日2007-06-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J.Biol.Chem., 282, 2007
4XO2
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CRYSTAL STRUCTURE OF GNSA FROM E.COLI
分子名称:Protein GnsA
著者Zhan, L.H., Gao, Z.Q., Wei, Y., Dong, Y.H.
登録日2015-01-16
公開日2015-06-17
実験手法X-RAY DIFFRACTION (1.952 Å)
主引用文献Crystal structure of GnsA from Escherichia coli
Biochem.Biophys.Res.Commun., 462, 2015
1S14
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TOPOISOMERASE IV PARE 24KDA SUBUNIT
分子名称:Topoisomerase IV subunit B, NOVOBIOCIN
著者Wei, Y., Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
1S16
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CRYSTAL STRUCTURE OF E. COLI TOPOISOMERASE IV PARE 43KDA SUBUNIT COMPLEXED WITH ADPNP
分子名称:Topoisomerase IV subunit B, MAGNESIUM ION, SULFATE ION, ...
著者Wei, Y., Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
2OI0
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CRYSTAL STRUCTURE ANALYSIS 0F THE TNF-A COVERTING ENZYME (TACE) IN COMPLEXED WITH ARYL-SULFONAMIDE
分子名称:TNF- a Converting Enzyme (TACE), ZINC ION, (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL
著者Wei, Y., Rao, G.B., Bandarage, U.K.
登録日2007-01-10
公開日2007-11-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Bioorg.Med.Chem.Lett., 17, 2007
3B92
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NOVEL THIO-BASED TACE INHIBITORS PART 2: RATIONAL DESIGN, SYNTHESIS AND SAR OF THIOL-CONTANING ARYL SUFONES
分子名称:ADAM 17, ZINC ION, 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
著者Wei, Y.
登録日2007-11-02
公開日2007-12-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg.Med.Chem.Lett., 18, 2008
3G75
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS GYRASE B CO-COMPLEXED WITH 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE INHIBITOR
分子名称:DNA gyrase subunit B, 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole
著者Wei, Y., Charifson, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2013-07-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010