Author results

2PP4
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SOLUTION STRUCTURE OF ETO-TAFH REFINED IN EXPLICIT SOLVENT
Descriptor:Protein ETO
Authors:Wei, Y., Liu, S., Lausen, J., Woodrell, C., Cho, S., Biris, N., Kobayashi, N., Yokoyama, S., Werner, M.H.
Deposit date:2007-04-27
Release date:2007-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription
Nat.Struct.Mol.Biol., 14, 2007
1ESC
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1FTN
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CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX
Descriptor:TRANSFORMING PROTEIN RHOA (H12), MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Wei, Y., Zhang, Y., Derewenda, U., Liu, X., Minor, W., Nakamoto, R.K., Somlyo, A.V., Somlyo, A.P., Derewenda, Z.S.
Deposit date:1997-03-13
Release date:1998-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of RhoA-GDP and its functional implications.
Nat.Struct.Biol., 4, 1997
4I8O
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CRYSTAL STRUCTURE OF THE TOXIN RNLA FROM ESCHERICHIA COLI
Descriptor:TOXIN RNLA
Authors:Wei, Y., Gao, Z.Q., Zhang, H., Dong, Y.H.
Deposit date:2012-12-04
Release date:2013-10-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.104 Å)
Cite:Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance.
Mol.Microbiol., 90, 2013
1ESD
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE, METHYLPHOSPHONIC ACID ESTER GROUP
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1ESE
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THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES
Descriptor:ESTERASE, DIETHYL PHOSPHONATE
Authors:Wei, Y., Schottel, J.L., Derewenda, U., Swenson, L., Patkar, S., Derewenda, Z.S.
Deposit date:1994-10-07
Release date:1995-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel variant of the catalytic triad in the Streptomyces scabies esterase.
Nat.Struct.Biol., 2, 1995
1F1J
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CRYSTAL STRUCTURE OF CASPASE-7 IN COMPLEX WITH ACETYL-ASP-GLU-VAL-ASP-CHO
Descriptor:CASPASE-7 PROTEASE, ACE-ASP-GLU-VAL-ASP-CHO, SULFATE ION
Authors:Wei, Y., Charifson, P.S.
Deposit date:2000-05-19
Release date:2001-05-23
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Chem.Biol., 7, 2000
1JFR
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CRYSTAL STRUCTURE OF THE STREPTOMYCES EXFOLIATUS LIPASE AT 1.9A RESOLUTION: A MODEL FOR A FAMILY OF PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES
Descriptor:LIPASE
Authors:Wei, Y., Derewenda, Z.S.
Deposit date:1997-07-11
Release date:1998-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution.
Structure, 6, 1998
1JKM
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BREFELDIN A ESTERASE, A BACTERIAL HOMOLOGUE OF HUMAN HORMONE SENSITIVE LIPASE
Descriptor:BREFELDIN A ESTERASE
Authors:Wei, Y., Contreras, A.J., Sheffield, P., Osterlund, T., Derewenda, U., Matern, U.O., Derewenda, Z.S.
Deposit date:1998-02-04
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase.
Nat.Struct.Biol., 6, 1999
1P68
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SOLUTION STRUCTURE OF S-824, A DE NOVO DESIGNED FOUR HELIX BUNDLE
Descriptor:De novo designed protein S-824
Authors:Wei, Y., Kim, S., Fela, D., Baum, J., Hecht, M.H.
Deposit date:2003-04-29
Release date:2003-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a de novo protein from a designed combinatorial library.
Proc.Natl.Acad.Sci.Usa, 100, 2003
2QV1
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CRYSTAL STRUCTURE OF HCV NS3-4A V36M MUTANT
Descriptor:NS3, peptide, ZINC ION
Authors:Wei, Y.
Deposit date:2007-08-07
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Phenotypic and Structural Analyses of HCV NS3 Protease Val36 Variants
To be Published
3FV5
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CRYSTAL STRUCTURE OF E. COLI TOPOISOMERASE IV CO-COMPLEXED WITH INHIBITOR
Descriptor:DNA topoisomerase 4 subunit B, 1-(4-acetyl-6-pyridin-3-yl-1H-benzimidazol-2-yl)-3-ethylurea
Authors:Wei, Y., Charifson, P., LeTiran, A.
Deposit date:2009-01-15
Release date:2010-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
To be Published
5I8J
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CRYSTAL STRUCTURE OF DMD FROM PHAGE RB69
Descriptor:Dmd discriminator of mRNA degradation
Authors:Wei, Y., Zhang, H., Gao, Z.Q., Dong, Y.H.
Deposit date:2016-02-19
Release date:2017-02-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural characterizations of phage antitoxin Dmd and its interactions with bacterial toxin RnlA
Biochem. Biophys. Res. Commun., 472, 2016
6E7O
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CRYSTAL STRUCTURE OF DEGLYCOSYLATED HUMAN EPDR1
Descriptor:Mammalian ependymin-related protein 1
Authors:Wei, Y., Prive, G.G.
Deposit date:2018-07-27
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
Commun Biol, 2, 2019
6E8N
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CRYSTAL STRUCTURE OF GLYCOSYLATED HUMAN EPDR1
Descriptor:Mammalian ependymin-related protein 1, NONAETHYLENE GLYCOL
Authors:Wei, Y., Prive, G.G.
Deposit date:2018-07-30
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
Commun Biol, 2, 2019
6BY9
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CRYSTAL STRUCTURE OF EHMT1
Descriptor:Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
Authors:Dong, A., Wei, Y., Li, A., Tempel, W., Han, S., Sunnerhagen, M., Penn, L., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
Deposit date:2017-12-20
Release date:2018-01-31
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of EHMT1
to be published
2OIN
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CRYSTAL STRUCTURE OF HCV NS3-4A R155K MUNTANT
Descriptor:Polyprotein, NS4A peptide, ZINC ION
Authors:Wei, Y.
Deposit date:2007-01-11
Release date:2007-06-05
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J.Biol.Chem., 282, 2007
4XO2
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CRYSTAL STRUCTURE OF GNSA FROM E.COLI
Descriptor:Protein GnsA
Authors:Zhan, L.H., Gao, Z.Q., Wei, Y., Dong, Y.H.
Deposit date:2015-01-16
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Crystal structure of GnsA from Escherichia coli
Biochem.Biophys.Res.Commun., 462, 2015
1S14
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI TOPOISOMERASE IV PARE 24KDA SUBUNIT
Descriptor:Topoisomerase IV subunit B, NOVOBIOCIN
Authors:Wei, Y., Gross, C.H.
Deposit date:2004-01-05
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
1S16
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CRYSTAL STRUCTURE OF E. COLI TOPOISOMERASE IV PARE 43KDA SUBUNIT COMPLEXED WITH ADPNP
Descriptor:Topoisomerase IV subunit B, MAGNESIUM ION, SULFATE ION, ...
Authors:Wei, Y., Gross, C.H.
Deposit date:2004-01-05
Release date:2004-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
2OI0
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CRYSTAL STRUCTURE ANALYSIS 0F THE TNF-A COVERTING ENZYME (TACE) IN COMPLEXED WITH ARYL-SULFONAMIDE
Descriptor:TNF- a Converting Enzyme (TACE), ZINC ION, (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL
Authors:Wei, Y., Rao, G.B., Bandarage, U.K.
Deposit date:2007-01-10
Release date:2007-11-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Bioorg.Med.Chem.Lett., 17, 2007
3B92
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NOVEL THIO-BASED TACE INHIBITORS PART 2: RATIONAL DESIGN, SYNTHESIS AND SAR OF THIOL-CONTANING ARYL SUFONES
Descriptor:ADAM 17, ZINC ION, 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
Authors:Wei, Y.
Deposit date:2007-11-02
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg.Med.Chem.Lett., 18, 2008
3G75
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS GYRASE B CO-COMPLEXED WITH 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE INHIBITOR
Descriptor:DNA gyrase subunit B, 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole
Authors:Wei, Y., Charifson, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G7B
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STAPHYLOCOCCUS AUREUS GYRASE B CO-COMPLEX WITH METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE INHIBITOR
Descriptor:DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate
Authors:Wei, Y., Charisfon, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G7E
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CRYSTAL STRUCTURE OF E. COLI GYRASE B CO-COMPLEXED WITH PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE INHIBITOR
Descriptor:DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate
Authors:Wei, Y., Charifson, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010