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7DG4
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BU of 7dg4 by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 6
Descriptor: 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-10
Release date:2021-11-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DHN
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BU of 7dhn by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 20
Descriptor: 7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-16
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DH3
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BU of 7dh3 by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 5
Descriptor: 2,7-dimethoxy-9-piperidin-4-ylsulfanyl-acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-12
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:The co-crystal structure of DYRK2 with a small molecule inhibitor 5
To Be Published
7DHO
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BU of 7dho by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 14
Descriptor: 2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-16
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DH9
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BU of 7dh9 by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 7
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-13
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DHC
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BU of 7dhc by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 10
Descriptor: 4-[bis(fluoranyl)methyl]-2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-13
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.592 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DHH
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BU of 7dhh by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 19
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [9-(azetidin-3-ylmethylsulfanyl)-2,7-dimethoxy-acridin-4-yl]methanol
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-14
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DHK
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BU of 7dhk by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 13
Descriptor: 2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-16
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.341 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DHV
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BU of 7dhv by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 8
Descriptor: 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine-4-carboxylic acid, Dual specificity tyrosine-phosphorylation-regulated kinase 2
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-17
Release date:2021-11-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.679 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DJO
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BU of 7djo by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 17
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-20
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
7DL6
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BU of 7dl6 by Molmil
The co-crystal structure of DYRK2 with a small molecule inhibitor 18
Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3R)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol
Authors:Wei, T, Xiao, J.
Deposit date:2020-11-26
Release date:2021-12-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.648 Å)
Cite:Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.
Elife, 11, 2022
8J4T
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BU of 8j4t by Molmil
GajA-GajB complex
Descriptor: Endonuclease GajA, Gabija protein GajB
Authors:Wei, T, Ma, J, Huo, Y.
Deposit date:2023-04-20
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural and biochemical insights into the mechanism of the Gabija bacterial immunity system.
Nat Commun, 15, 2024
3TEF
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BU of 3tef by Molmil
Crystal Structure of the Periplasmic Catecholate-Siderophore Binding Protein VctP from Vibrio Cholerae
Descriptor: Iron(III) ABC transporter, periplasmic iron-compound-binding protein
Authors:Liu, X, Wang, Z, Liu, S, Li, N, Chen, Y, Zhu, C, Zhu, D, Wei, T, Huang, Y, Xu, S, Gu, L.
Deposit date:2011-08-13
Release date:2012-08-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Crystal structure of periplasmic catecholate-siderophore binding protein VctP from Vibrio cholerae at 1.7 A resolution
Febs Lett., 586, 2012
3TB4
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BU of 3tb4 by Molmil
Crystal structure of the ISC domain of VibB
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Liu, S, Zhang, C, Niu, B, Li, N, Liu, M, Wei, T, Zhu, D, Xu, S, Gu, L.
Deposit date:2011-08-05
Release date:2012-08-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction
Acta Crystallogr.,Sect.D, 68, 2012
3TGV
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BU of 3tgv by Molmil
Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae
Descriptor: BENZOIC ACID, Heme-binding protein HutZ
Authors:Liu, X, Gong, J, Wang, Z, Du, Q, Wei, T, Zhu, D, Huang, Y, Xu, S, Gu, L.
Deposit date:2011-08-17
Release date:2012-08-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Crystal structure of HutZ,the heme storsge protein from Vibrio cholerae
To be Published
3TG2
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BU of 3tg2 by Molmil
Crystal structure of the ISC domain of VibB in complex with isochorismate
Descriptor: (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, TRIETHYLENE GLYCOL, Vibriobactin-specific isochorismatase
Authors:Liu, S, Zhang, C, Niu, B, Li, N, Liu, X, Liu, M, Wei, T, Zhu, D, Huang, Y, Xu, S, Gu, L.
Deposit date:2011-08-17
Release date:2012-08-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction
Acta Crystallogr.,Sect.D, 68, 2012
7V3P
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BU of 7v3p by Molmil
Cryo-EM structure of the IGF1R/insulin complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ...
Authors:Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C.
Deposit date:2021-08-11
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the IGF1R/insulin complex
To Be Published
4WXM
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BU of 4wxm by Molmil
FleQ REC domain from Pseudomonas aeruginosa PAO1
Descriptor: Transcriptional regulator FleQ
Authors:Su, T, Liu, S, Gu, L.
Deposit date:2014-11-14
Release date:2015-09-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator
J.Struct.Biol., 192, 2015
4DOY
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BU of 4doy by Molmil
Crystal structure of Dibenzothiophene desulfurization enzyme C
Descriptor: Dibenzothiophene desulfurization enzyme C, GLYCEROL
Authors:Liu, S, Zhang, C, Zhu, D, Gu, L.
Deposit date:2012-02-12
Release date:2013-02-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.789 Å)
Cite:Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom
Proteins, 82, 2014
5GPO
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BU of 5gpo by Molmil
The sensor domain structure of the zinc-responsive histidine kinase CzcS from Pseudomonas Aeruginosa
Descriptor: SULFATE ION, Sensor protein CzcS, ZINC ION
Authors:Wang, D, Chen, W.Z, Huang, S.Q, Liu, X.C, Hu, Q.Y, Wei, T.B, Gan, J.H, Chen, H.
Deposit date:2016-08-03
Release date:2017-08-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa
PLoS Pathog., 13, 2017
4ZXD
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BU of 4zxd by Molmil
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD
Descriptor: Hydroquinone dioxygenase large subunit, Hydroquinone dioxygenase small subunit
Authors:Liu, S, Su, T, Zhang, C, Gu, L.
Deposit date:2015-05-20
Release date:2015-09-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.052 Å)
Cite:Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
4ZXC
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BU of 4zxc by Molmil
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Fe3+
Descriptor: FE (III) ION, Hydroquinone dioxygenase large subunit, Hydroquinone dioxygenase small subunit
Authors:Liu, S, Su, T, Zhang, C, Gu, L.
Deposit date:2015-05-20
Release date:2015-09-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
4ZXA
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BU of 4zxa by Molmil
Crystal Structure of hydroquinone 1,2-dioxygenase PnpCD in complex with Cd2+ and 4-hydroxybenzonitrile
Descriptor: 4-hydroxybenzonitrile, CADMIUM ION, Hydroquinone dioxygenase large subunit, ...
Authors:Liu, S, Su, T, Zhang, C, Gu, L.
Deposit date:2015-05-20
Release date:2015-09-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases.
J.Biol.Chem., 290, 2015
4ES4
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BU of 4es4 by Molmil
Crystal structure of YdiV and FlhD complex
Descriptor: Flagellar transcriptional regulator FlhD, Putative cyclic di-GMP regulator CdgR
Authors:Li, B, Gu, L.
Deposit date:2012-04-22
Release date:2012-10-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural insight of a concentration-dependent mechanism by which YdiV inhibits Escherichia coli flagellum biogenesis and motility
Nucleic Acids Res., 40, 2012
3Q7J
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BU of 3q7j by Molmil
Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development
Descriptor: L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION
Authors:Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L.
Deposit date:2011-01-05
Release date:2011-07-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development
Bioorg.Med.Chem., 19, 2011

 

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