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2H7E
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BU of 2h7e by Molmil
Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide- minimized average structure
Descriptor: Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma, Talin-1
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2H7D
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BU of 2h7d by Molmil
Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase peptide
Descriptor: Chimera of 24-mer peptide from Integrin beta-3 and 10-mer peptide from Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma, Talin-1
Authors:Wegener, K.L.
Deposit date:2006-06-02
Release date:2007-01-30
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural basis of integrin activation by talin
CELL(CAMBRIDGE,MASS.), 128, 2007
2K00
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BU of 2k00 by Molmil
Solution structure of the talin F3 in complex with layilin cytodomain
Descriptor: Layilin, Talin-1
Authors:Wegener, K.L, Barsukov, I.L.
Deposit date:2008-01-23
Release date:2008-09-09
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain
J.Mol.Biol., 382, 2008
6CIV
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BU of 6civ by Molmil
Lactam cyclised mimetic of a fragment of p21
Descriptor: p21
Authors:Wegener, K.L.
Deposit date:2018-02-25
Release date:2018-07-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CEJ
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BU of 6cej by Molmil
Solution structure of a 14mer fragment of the p21 protein
Descriptor: Cyclin-dependent kinase inhibitor 1
Authors:Wegener, K.L.
Deposit date:2018-02-12
Release date:2018-07-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CIX
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BU of 6cix by Molmil
Lactam cyclised mimetic of a fragment of p21
Descriptor: p21
Authors:Wegener, K.L.
Deposit date:2018-02-25
Release date:2018-07-04
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
6CBI
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BU of 6cbi by Molmil
PCNA in complex with inhibitor
Descriptor: GLY-ARG-LYS-ARG-ARG-GLN-DAB-SER-MET-THR-GLU-PHE-TYR-HIS, Proliferating cell nuclear antigen, SULFATE ION
Authors:Bruning, J.B, Wegener, K.L.
Deposit date:2018-02-03
Release date:2018-07-04
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Rational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Chemistry, 24, 2018
4WOP
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BU of 4wop by Molmil
Nucleotide Triphosphate Promiscuity in Mycobacterium tuberculosis Dethiobiotin Synthetase
Descriptor: ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, SULFATE ION
Authors:Salaemae, W, Yap, M.Y, Wegener, K.L, Booker, G.W, Wilce, M.C.J, Polyak, S.W.
Deposit date:2014-10-16
Release date:2015-04-08
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.393 Å)
Cite:Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase.
Tuberculosis (Edinb), 95, 2015
2V76
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BU of 2v76 by Molmil
Crystal structure of the human dok1 PTB domain
Descriptor: 1,2-ETHANEDIOL, DOCKING PROTEIN 1, GLYCEROL, ...
Authors:Oxley, C.L, Anthis, N.J, Lowe, E.D, Campbell, I.D, Wegener, K.L.
Deposit date:2007-07-26
Release date:2008-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Integrin Phosphorylation Switch: The Effect of {Beta}3 Integrin Tail Phosphorylation on Dok1 and Talin Binding.
J.Biol.Chem., 283, 2008
7RML
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BU of 7rml by Molmil
Neisseria meningitidis Methylenetetrahydrofolate reductase in complex with FAD
Descriptor: 5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Pederick, J.L, Wegener, K.L, Salaemae, W, Bruning, J.B.
Deposit date:2021-07-27
Release date:2022-11-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Biochemical and structural characterization of meningococcal methylenetetrahydrofolate reductase.
Protein Sci., 32, 2023
3G9W
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BU of 3g9w by Molmil
Crystal Structure of Talin2 F2-F3 in Complex with the Integrin Beta1D Cytoplasmic Tail
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Integrin beta-1D, ...
Authors:Anthis, N.J, Wegener, K.L, Ye, F, Kim, C, Lowe, E.D, Vakonakis, I, Bate, N, Critchley, D.R, Ginsberg, M.H, Campbell, I.D.
Deposit date:2009-02-15
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.165 Å)
Cite:The structure of an integrin/talin complex reveals the basis of inside-out signal transduction
Embo J., 28, 2009
5TUP
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BU of 5tup by Molmil
X-ray Crystal Structure of the Aspergillus fumigatus Sliding Clamp
Descriptor: Proliferating cell nuclear antigen
Authors:Bruning, J.B, Marshall, A.C, Kroker, A.J, Wegener, K.L, Rajapaksha, H.
Deposit date:2016-11-06
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.
FEBS J., 284, 2017
6CZD
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BU of 6czd by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with adenosine diphosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION
Authors:Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W.
Deposit date:2018-04-09
Release date:2018-10-24
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
6NMZ
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BU of 6nmz by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with an intentionally produced fragment degradation product B9D
Descriptor: ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, [(1R,2S)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetic acid, ...
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-14
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with an intentionally produced fragment degradation product B9D
To Be Published
6NVD
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BU of 6nvd by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with triazole linked compound 9
Descriptor: 2',5'-dideoxy-5'-[4-({[(1S,2R)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetyl}amino)-1H-1,2,3-triazol-1-yl]cytidine, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-02-05
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with triazole linked compound 9
To Be Published
6NKA
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BU of 6nka by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine
Descriptor: 2'-DEOXYCYTIDINE, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-07
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine
To Be Published
6NL5
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BU of 6nl5 by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine triphosphate
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-08
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.314 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine triphosphate
To Be Published
6NVF
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BU of 6nvf by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8
Descriptor: (4-{[(1R,2R)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic acid, (4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic acid, ATP-dependent dethiobiotin synthetase BioD, ...
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-02-05
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.989 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8
To Be Published
6NLZ
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BU of 6nlz by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment degradation product B9D
Descriptor: ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, [(1R,2S)-2-(2-hydroxybenzene-1-carbonyl)cyclopentyl]acetic acid, ...
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-10
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment degradation product B9D
To Be Published
6NN0
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BU of 6nn0 by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine and fragment degradation product B9D
Descriptor: 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, ATP-dependent dethiobiotin synthetase BioD, SULFATE ION, ...
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-14
Release date:2020-01-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with 2'-deoxycytidine and B9D
To Be Published
6NKB
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BU of 6nkb by Molmil
Crystal structure of Dethiobiotin Synthetase from Mycobacterium tuberculosis in complex with 2'-deoxycytidine diphosphate
Descriptor: ATP-dependent dethiobiotin synthetase BioD, DEOXYCYTIDINE DIPHOSPHATE, MAGNESIUM ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-07
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Dethiobiotin Synthetase from Mycobacterium tuberculosis in complex with 2'-deoxycytidine diphosphate
To be published
6NL4
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BU of 6nl4 by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine
Descriptor: ATP-dependent dethiobiotin synthetase BioD, GEMCITABINE, SULFATE ION
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-07
Release date:2020-01-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with gemcitabine
To Be Published
6NWN
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BU of 6nwn by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with glutamic acid linked compound 10
Descriptor: 5'-{[N-({(1S,2R)-2-[4-(carboxymethyl)benzene-1-carbonyl]cyclopentyl}acetyl)-L-gamma-glutamyl]amino}-2',5'-dideoxycytidine, ATP-dependent dethiobiotin synthetase BioD, CITRIC ACID
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-02-06
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.005 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with glutamic acid linked compound 10
To Be Published
6NWG
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BU of 6nwg by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 3a
Descriptor: ATP-dependent dethiobiotin synthetase BioD, [(1R,2R)-2-(2-methoxybenzene-1-carbonyl)cyclopentyl]propanedioic acid
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-02-06
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.939 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 3a
To Be Published
6NU6
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BU of 6nu6 by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5
Descriptor: 4-[(1R,2S)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, 4-[(1S,2R)-2-(carboxymethyl)cyclopentane-1-carbonyl]benzoic acid, ATP-dependent dethiobiotin synthetase BioD, ...
Authors:Thompson, A.P, Polyak, S.W, Wegener, K.L, Bruning, J.B.
Deposit date:2019-01-31
Release date:2020-02-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.437 Å)
Cite:Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 5
To Be Published

 

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